Disruption of neurite morphology parallels MS progression.

Spanò, Barbara, Giulietti, Giovanni, Pisani, Valerio, Morreale, Manuela, Tuzzi, Elisa, Nocentini, Ugo, Francia, Ada, Caltagirone, Carlo, Bozzali, Marco and Cercignani, Mara ORCID: https://orcid.org/0000-0002-4550-2456 2018. Disruption of neurite morphology parallels MS progression. Neurology, Neuroimmunology and Neuroinflammation 5 (6) , e502. 10.1212/NXI.0000000000000502

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Abstract

Objectives To apply advanced diffusion MRI methods to the study of normal-appearing brain tissue in MS and examine their correlation with measures of clinical disability. Methods A multi-compartment model of diffusion MRI called neurite orientation dispersion and density imaging (NODDI) was used to study 20 patients with relapsing-remitting MS (RRMS), 15 with secondary progressive MS (SPMS), and 20 healthy controls. Maps of NODDI were analyzed voxel-wise to assess the presence of abnormalities within the normal-appearing brain tissue and the association with disease severity. Standard diffusion tensor imaging (DTI) parameters were also computed for comparing the 2 techniques. Results Patients with MS showed reduced neurite density index (NDI) and increased orientation dispersion index (ODI) compared with controls in several brain areas (p < 0.05), with patients with SPMS having more widespread abnormalities. DTI indices were also sensitive to some changes. In addition, patients with SPMS showed reduced ODI in the thalamus and caudate nucleus. These abnormalities were associated with scores of disease severity (p < 0.05). The association with the MS functional composite score was higher in patients with SPMS compared with patients with RRMS. Conclusions NODDI and DTI findings are largely overlapping. Nevertheless, NODDI helps interpret previous findings of increased anisotropy in the thalamus of patients with MS and are consistent with the degeneration of selective axon populations.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Lippincott, Williams & Wilkins: Creative Commons Attribution Non-Commercial No Derivatives License / Wolters Kluwer Health/LWW
ISSN:	2332-7812
Date of First Compliant Deposit:	12 March 2021
Date of Acceptance:	7 August 2018
Last Modified:	06 May 2023 11:00
URI:	https://orca.cardiff.ac.uk/id/eprint/139576

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