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Growth factor therapy for Parkinson's disease: alternative delivery systems

Jarrin, Sarah, Hakami, Abrar, Newland, Ben and Dowd, Eilís 2021. Growth factor therapy for Parkinson's disease: alternative delivery systems. Journal of Parkinson's Disease 11 (S2) , S229-S236. 10.3233/JPD-212662

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Abstract

Despite decades of research and billions in global investment, there remains no preventative or curative treatment for any neurodegenerative condition, including Parkinson’s disease (PD). Arguably, the most promising approach for neuroprotection and neurorestoration in PD is using growth factors which can promote the growth and survival of degenerating neurons. However, although neurotrophin therapy may seem like the ideal approach for neurodegenerative disease, the use of growth factors as drugs presents major challenges because of their protein structure which creates serious hurdles related to accessing the brain and specific targeting of affected brain regions. To address these challenges, several different delivery systems have been developed, and two major approaches—direct infusion of the growth factor protein into the target brain region and in vivo gene therapy—have progressed to clinical trials in patients with PD. In addition to these clinically evaluated approaches, a range of other delivery methods are in various degrees of development, each with their own unique potential. This review will give a short overview of some of these alternative delivery systems, with a focus on ex vivo gene therapy and biomaterial-aided protein and gene delivery, and will provide some perspectives on their potential for clinical development and translation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Publisher: IOS Press
ISSN: 1877-7171
Date of First Compliant Deposit: 5 July 2021
Date of Acceptance: 31 March 2021
Last Modified: 06 Oct 2021 13:54
URI: http://orca.cardiff.ac.uk/id/eprint/142391

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