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Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults

Ponsford, Mark J., Jefferies, Rhys, Davies, Chris, Farewell, Daniel, Humphreys, Ian R., Jolles, Stephen, Fairbairn, Sara, Lewis, Keir, Menzies, Daniel, Benjamin, Amit, Thaivalappil, Favas, Williams, Chris and Barry, Simon M. 2021. Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults. Thorax 10.1136/thoraxjnl-2021-216964

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Abstract

The burden of nosocomial SARS-CoV-2 infection remains poorly defined. We report on the outcomes of 2508 adults with molecularly-confirmed SARS-CoV-2 admitted across 18 major hospitals, representing over 60% of those hospitalised across Wales between 1 March and 1 July 2020. Inpatient mortality for nosocomial infection ranged from 38% to 42%, consistently higher than participants with community-acquired infection (31%–35%) across a range of case definitions. Those with hospital-acquired infection were older and frailer than those infected within the community. Nosocomial diagnosis occurred a median of 30 days following admission (IQR 21–63), suggesting a window for prophylactic or postexposure interventions, alongside enhanced infection control measures.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Medicine
Additional Information: This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license
Publisher: BMJ Publishing Group
ISSN: 0040-6376
Funders: Wellcome Trust, MRC
Date of First Compliant Deposit: 29 July 2021
Date of Acceptance: 18 June 2021
Last Modified: 11 Aug 2021 13:16
URI: http://orca.cardiff.ac.uk/id/eprint/142881

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