Pepper, Chris, Norris, Kevin and Fegan, Christopher ORCID: https://orcid.org/0000-0001-9685-0621 2020. Clinical utility of telomere length measurements in cancer. Current Opinion in Genetics and Development 60 , pp. 107-111. 10.1016/j.gde.2020.02.012 |
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Abstract
Cancer remains one of the leading causes of death in the developed world and despite impressive advances in therapeutic modalities, only a small subset of patients are currently cured. The underlying genetic heterogeneity of cancers clearly plays a crucial role in determining both the clinical course of individual pathologies and their responses to standard treatments. Although every tumour is to some extent distinct, there are recurrent features of cancers that can be exploited as therapeutic targets and as prognostic and predictive biomarkers; one such attribute is telomere length. Here we discuss the utility of telomere length evaluation in cancer and describe some of the promise and challenges of bringing this into clinical practice.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Publisher: | Elsevier |
ISSN: | 0959-437X |
Date of First Compliant Deposit: | 13 September 2021 |
Date of Acceptance: | 6 February 2020 |
Last Modified: | 06 May 2023 00:44 |
URI: | https://orca.cardiff.ac.uk/id/eprint/144045 |
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