Browse by Current Cardiff authors

Louise, Carr, Norris, Kevin, Helen, Parker, Anna, Nilsson-Takeuchi, Dean, Bryant, Harindra, Amarasinghe, Latha, Kadalayil, Monica, Else, Andrew, Pettitt, Peter, Hillmen, Anna, Schuh, Renata, Walewska, Baird, Duncan ORCID: https://orcid.org/0000-0001-8408-5467, G., Oscier David, C., Oakes Christopher, Jane, Gibson, Pepper, Christopher and C., Strefford Jonathan 2024. Letter to the Editor: Telomere length and DNA methylation epitype both provide independent prognostic information in CLL patients; data from the UK CLL, ARCTIC and ADMIRE clinical trials. British Journal of Haematology 205 (5) , pp. 2072-2076. 10.1111/bjh.19765

Fegan, Gregory, Tod, Daniel, Downing, Abigail, Elmusharaf, Nagah, Pepper, Christopher and Fegan, Christopher ORCID: https://orcid.org/0000-0001-9685-0621 2024. Social deprivation independently impacts clinical outcomes in patients with chronic lymphocytic leukemia. Haematologica 109 (5) 10.3324/haematol.2023.283527

Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Ferrari, Valentina ORCID: https://orcid.org/0000-0003-1895-8906, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Ghazaly, Essam and Pepper, Chris 2022. Synthesis and characterization of nuc-7738, an aryloxy phosphoramidate of 3?-deoxyadenosine, as a potential anticancer agent. Journal of Medicinal Chemistry 65 (23) , pp. 15789-15804. 10.1021/acs.jmedchem.2c01348

Pepper, Andrea G. S., Zucchetto, Antonella, Norris, Kevin, Tissino, Erika, Polesel, Jerry, Soe, Zarni, Allsup, David, Hockaday, Anna, Ow, Pei Loo, Hillmen, Peter, Rawstron, Andrew, Catovsky, Daniel, Bulian, Pietro, Bomben, Riccardo, Baird, Duncan M. ORCID: https://orcid.org/0000-0001-8408-5467, Fegan, Christopher D. ORCID: https://orcid.org/0000-0001-9685-0621, Gattei, Valter and Pepper, Chris 2022. Combined analysis of IGHV mutations, telomere length and CD49d identifies long-term progression-free survivors in TP53 wild-type CLL treated with FCR-based therapies. Leukemia 36 , pp. 271-274. 10.1038/s41375-021-01322-1

Alsagaby, Suliman A., Brewis, Ian A., Vijayakumar, Rajendran, Alhumaydhi, Fahad A., Alwashmi, Ameen S., Alharbi, Naif K., Al Abdulmonem, Waleed, Premanathan, Mariappan, Pratt, Guy, Fegan, Christopher ORCID: https://orcid.org/0000-0001-9685-0621, Pepper, Christopher and Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 2021. Proteomics-based identification of cancer-associated proteins in chronic lymphocytic leukaemia. Electronic Journal of Biotechnology 52 , pp. 1-12. 10.1016/j.ejbt.2021.04.006

Elston, Lauren, Fegan, Chris ORCID: https://orcid.org/0000-0001-9685-0621, Hills, Robert ORCID: https://orcid.org/0000-0003-0166-0062, Hashimdeen, Shaikh S., Walsby, Elisabeth ORCID: https://orcid.org/0000-0001-8523-5017, Henley, Peter, Pepper, Chris and Man, Stephen ORCID: https://orcid.org/0000-0001-9103-1686 2020. Increased frequency of CD4+PD-1+HLA-DR+ T cells is associated with disease progression in CLL. British Journal of Haematology 188 (6) , pp. 872-880. 10.1111/bjh.16260

Pepper, Chris, Norris, Kevin and Fegan, Christopher ORCID: https://orcid.org/0000-0001-9685-0621 2020. Clinical utility of telomere length measurements in cancer. Current Opinion in Genetics and Development 60 , pp. 107-111. 10.1016/j.gde.2020.02.012

Cohen, Jared A., Rossi, Francesca Maria, Zucchetto, Antonella, Bomben, Riccardo, Terzi-di-Bergamo, Lodovico, Rabe, Kari G., Degan, Massimo, Steffan, Agostino, Polesel, Jerry, Santinelli, Enrico, Innocenti, Idanna, Cutrona, Giovanna, D' Arena, Giovanni, Pozzato, Gabriele, Zaja, Francesco, Chiarenza, Annalisa, Rossi, Davide, Di Raimondo, Francesco, Laurenti, Luca, Gentile, Massimo, Morabito, Fortunato, Neri, Antonino, Ferrarini, Manlio, Fegan, Christopher D. ORCID: https://orcid.org/0000-0001-9685-0621, Pepper, Christopher J., Del Poeta, Giovanni, Parikh, Sameer A., Kay, Neil E. and Gattei, Valter 2019. A laboratory-based scoring system predicts early treatment in Rai 0 chronic lymphocytic leukemia. Haematologica 104 (11) , 228171. 10.3324/haematol.2019.228171

Rahaman, Muhammed H., Lam, Frankie, Zhong, Longjin, Teo, Theodosia, Adams, Julian, Yu, Mingfeng, Milne, Robert W., Pepper, Chris, Lokman, Noor A., Ricciardelli, Carmela, Oehler, Martin and Wang, Shudong 2019. Targeting CDK 9 for treatment of colorectal cancer. Molecular Oncology 13 (10) , pp. 2178-2193. 10.1002/1878-0261.12559

Norris, Kevin, Hillmen, Peter, Rawstron, Andrew, Hills, Robert, Baird, Duncan M. ORCID: https://orcid.org/0000-0001-8408-5467, Fegan, Christopher D. ORCID: https://orcid.org/0000-0001-9685-0621 and Pepper, Chris 2019. Telomere length predicts for outcome to FCR chemotherapy in CLL. Leukemia 33 , pp. 1953-1963. 10.1038/s41375-019-0389-9

Twohig, Jason P., Cardus Figueras, Ana, Andrews, Robert, Wiede, Florian, Cossins, Benjamin C., Derrac Soria, Alicia, Lewis, Myles J., Townsend, Michael J., Millrine, David ORCID: https://orcid.org/0000-0002-8041-0151, Li, Jasmine, Hill, David G., Uceda Fernandez, Javier, Liu, Xiao, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Pepper, Christopher J., Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Pitzalis, Costantino, Tiganis, Tony, Williams, Nigel M. ORCID: https://orcid.org/0000-0003-1177-6931, Jones, Gareth W. and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 2019. Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells. Nature Immunology 20 , pp. 458-470. 10.1038/s41590-019-0350-0

Went, Molly, Sud, Amit, Speedy, Helen, Sunter, Nicola J., Försti, Asta, Law, Philip J., Johnson, David C., Mirabella, Fabio, Holroyd, Amy, Li, Ni, Orlando, Giulia, Weinhold, Niels, van Duin, Mark, Chen, Bowang, Mitchell, Jonathan S., Mansouri, Larry, Juliusson, Gunnar, Smedby, Karin E, Jayne, Sandrine, Majid, Aneela, Dearden, Claire, Allsup, David J., Bailey, James R., Pratt, Guy, Pepper, Chris, Fegan, Chris ORCID: https://orcid.org/0000-0001-9685-0621, Rosenquist, Richard, Kuiper, Rowan, Stephens, Owen W., Bertsch, Uta, Broderick, Peter, Einsele, Hermann, Gregory, Walter M., Hillengass, Jens, Hoffmann, Per, Jackson, Graham H., Jöckel, Karl-Heinz, Nickel, Jolanta, Nöthen, Markus M., da Silva Filho, Miguel Inacio, Thomsen, Hauke, Walker, Brian A., Broyl, Annemiek, Davies, Faith E., Hansson, Markus, Goldschmidt, Hartmut, Dyer, Martin J. S., Kaiser, Martin, Sonneveld, Pieter, Morgan, Gareth J., Hemminki, Kari, Nilsson, Björn, Catovsky, Daniel, Allan, James M. and Houlston, Richard S. 2018. Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology. Blood Cancer Journal 9 , 1. 10.1038/s41408-018-0162-8

Hyatt, Sam, Robinson, Rhiannon, Hepple, Nicole, Grimstead, Julia, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Fegan, Christopher ORCID: https://orcid.org/0000-0001-9685-0621, Jackson, Graham, allan, James, Pratt, Guy, Pepper, Christopher John and Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467 2017. Telomere length is a critical determinant for survival in multiple myeloma. British Journal of Haematology 178 (1) , pp. 94-98. 10.1111/bjh.14643

Williams, Jenna, Heppel, Nicole, Britt-Compton, Bethan, Grimstead, Julia, Robinson, Rhiannon, Tauro, Sudhir, Bowen, David, Knapper, Steven ORCID: https://orcid.org/0000-0002-6405-4441, Groves, Michael, Hills, Robert ORCID: https://orcid.org/0000-0003-0166-0062, Pepper, Christopher J., Baird, Duncan M. ORCID: https://orcid.org/0000-0001-8408-5467 and Fegan, Christopher D. ORCID: https://orcid.org/0000-0001-9685-0621 2017. Telomere length is an independent prognostic marker in MDS but not in de novo AML. British Journal of Haematology 178 (2) , pp. 240-249.

Law, Philip J., Berndt, Sonja I., Speedy, Helen E., Camp, Nicola J., Sava, Georgina P., Skibola, Christine F., Holroyd, Amy, Joseph, Vijai, Sunter, Nicola J., Nieters, Alexandra, Bea, Silvia, Monnereau, Alain, Martin-Garcia, David, Goldin, Lynn R., Clot, Guillem, Teras, Lauren R., Quintela, Inés, Birmann, Brenda M., Jayne, Sandrine, Cozen, Wendy, Majid, Aneela, Smedby, Karin E., Lan, Qing, Dearden, Claire, Brooks-Wilson, Angela R., Hall, Andrew G., Purdue, Mark P., Mainou-Fowler, Tryfonia, Vajdic, Claire M., Jackson, Graham H., Cocco, Pierluigi, Marr, Helen, Zhang, Yawei, Zheng, Tongzhang, Giles, Graham G., Lawrence, Charles, Call, Timothy G., Liebow, Mark, Melbye, Mads, Glimelius, Bengt, Mansouri, Larry, Glenn, Martha, Curtin, Karen, Diver, W. Ryan, Link, Brian K., Conde, Lucia, Bracci, Paige M., Holly, Elizabeth A., Jackson, Rebecca D., Tinker, Lesley F., Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Maynadie, Marc, McKay, James, Albanes, Demetrius, Weinstein, Stephanie, Wang, Zhaoming, Caporaso, Neil E., Morton, Lindsay M., Severson, Richard K., Riboli, Elio, Vineis, Paolo, Vermeulen, Roel C. H., Southey, Melissa C., Milne, Roger L., Clavel, Jacqueline, Topka, Sabine, Spinelli, John J., Kraft, Peter, Ennas, Maria Grazia, Summerfield, Geoffrey, Ferri, Giovanni M., Harris, Robert J., Miligi, Lucia, Pettitt, Andrew R., North, Kari E., Allsup, David J., Fraumeni, Joseph F., Bailey, James R., Offit, Kenneth, Pratt, Guy, Hjalgrim, Henrik, Pepper, Chris, Chanock, Stephen J., Fegan, Chris ORCID: https://orcid.org/0000-0001-9685-0621, Rosenquist, Richard, de Sanjose, Silvia, Carracedo, Angel, Dyer, Martin J. S., Catovsky, Daniel, Campo, Elias, Cerhan, James R., Allan, James M., Rothman, Nathanial, Houlston, Richard and Slager, Susan 2017. Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Nature Communications 8 , 14175. 10.1038/ncomms14175

Law, Philip J., Sud, Amit, Mitchell, Jonathan S., Henrion, Marc, Orlando, Giulia, Lenive, Oleg, Broderick, Peter, Speedy, Helen E., Johnson, David C., Kaiser, Martin, Weinhold, Niels, Cooke, Rosie, Sunter, Nicola J., Jackson, Graham H., Summerfield, Geoffrey, Harris, Robert J., Pettitt, Andrew R., Allsup, David J., Carmichael, Jonathan, Bailey, James R., Pratt, Guy, Rahman, Thahira, Pepper, Chris, Fegan, Chris ORCID: https://orcid.org/0000-0001-9685-0621, von Strandmann, Elke Pogge, Engert, Andreas, Försti, Asta, Chen, Bowang, Filho, Miguel Inacio da Silva, Thomsen, Hauke, Hoffmann, Per, Noethen, Markus M., Eisele, Lewin, Jöckel, Karl-Heinz, Allan, James M., Swerdlow, Anthony J., Goldschmidt, Hartmut, Catovsky, Daniel, Morgan, Gareth J., Hemminki, Kari and Houlston, Richard S. 2017. Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci. Scientific Reports 7 , 41071. 10.1038/srep41071

Pepper, Christopher John, Tu, Henry, Morrill, Paul, Garcia-Rates, Sara, Fegan, Christopher ORCID: https://orcid.org/0000-0001-9685-0621 and Greenfield, Susan 2017. Tumor cell migration is inhibited by a novel therapeutic strategy antagonizing the alpha-7 receptor. Oncotarget 10.18632/oncotarget.14545

Alsagaby, Suliman A., Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 and Pepper, Christopher 2016. Key molecular drivers of chronic lymphocytic leukemia. Clinical Lymphoma, Myeloma and Leukemia 16 (11) , pp. 593-606. 10.1016/j.clml.2016.08.008

Pasikowska, Marta, Walsby, Elisabeth ORCID: https://orcid.org/0000-0001-8523-5017, Apollonio, Bendetta, Cuthill, Kirsty, Phillips, Elizabeth, Coulter, Eve, Longhi, Maria Serena, Ma, Yun, Yallop, Deborah, Barber, Linda D., Patten, Piers, Fegan, Chris ORCID: https://orcid.org/0000-0001-9685-0621, Ramsay, Alan G., Pepper, Chris, Devereux, Stephen and Buggins, Andrea G. S. 2016. Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration. Blood 128 (4) , pp. 563-573. 10.1182/blood-2016-01-683128

Parry, Helen Marie, Damery, Sarah, Hudson, Christopher, Maurer, Matthew J., Cerhan, James R., Pachnio, Annette, Begum, Jusnara, Slager, Susan L., Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Man, Stephen ORCID: https://orcid.org/0000-0001-9103-1686, Pepper, Christopher John, Shanafelt, Tait D., Pratt, Guy and Moss, Paul A. H. 2016. Cytomegalovirus infection does not impact on survival or time to first treatment in patients with Chronic Lymphocytic Leukaemia. American Journal of Hematology 91 (8) , pp. 776-781. 10.1002/ajh.24403

Nichols, Eva-Marie, Jones, Rachel, Watson, Rachael, Pepper, Christopher John, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 and Marchbank, Kevin 2015. A CD21 low phenotype, with no evidence of autoantibodies to complement proteins, is consistent with a poor prognosis in CLL. Oncotarget 6 (32) , pp. 32669-32680. 10.18632/oncotarget.5404

Simpson, Katherine, Jones, R. E., Grimstead, Julia W., Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Pepper, Christopher John and Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467 2015. Telomere fusion threshold identifies a poor prognostic subset of breast cancer patients. Molecular Oncology 9 (6) , pp. 1186-1193. 10.1016/j.molonc.2015.02.003

Pepper, C., Buggins, A. G.S., Jones, C. H., Walsby, E. J. ORCID: https://orcid.org/0000-0001-8523-5017, Forconi, F., Pratt, G., Devereux, S., Stevenson, F. and Fegan, C. ORCID: https://orcid.org/0000-0001-9685-0621 2015. Phenotypic heterogeneity in IGHV-mutated CLL patients has prognostic impact and identifies a subset with increased sensitivity to BTK and PI3Kδ inhibition. Leukemia 29 , pp. 744-747. 10.1038/leu.2014.308

Sava, G. P., Speedy, H. E., Di Bernardo, M. C., Dyer, M. J. S., Holroyd, A., Sunter, N. J., Marr, H., Mansouri, L., Deaglio, S., Karabon, L., Frydecka, I., Jamroziak, K., Woszczyk, D., Juliusson, G., Smedby, K. E., Jayne, S., Majid, A., Wang, Y., Dearden, C., Hall, A. G., Mainou-Fowler, T., Jackson, G. H., Summerfield, G., Harris, R. J., Pettitt, A. R., Allsup, D. J., Bailey, J. R., Pratt, G., Pepper, C., Fegan, C. ORCID: https://orcid.org/0000-0001-9685-0621, Rosenquist, R., Catovsky, D., Allan, J. M. and Houlston, R. S. 2015. Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia risk. Leukemia 29 , pp. 748-751. 10.1038/leu.2014.311

Reid, Reiss, Redman, James Edward ORCID: https://orcid.org/0000-0001-5492-2869, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Pepper, Christopher John and Man, Stephen Tzekwung ORCID: https://orcid.org/0000-0001-9103-1686 2015. CD8+ T-cell recognition of a synthetic epitope formed by t-butyl modification. Immunology 144 (3) , pp. 495-505. 10.1111/imm.12398

Vaisitti, T., Audrito, V., Serra, S., Buonincontri, R., Sociali, G., Mannino, E., Pagnani, A., Zucchetto, A., Tissino, E., Vitale, C., Coscia, M., Usai, C., Pepper, C., Gattei, V., Bruzzone, S. and Deaglio, S. 2015. The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting. Leukemia 29 , pp. 356-368. 10.1038/leu.2014.207

Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 and Pepper, Christopher John 2015. Understanding cancer cell survival is key to patient survival. The Lancet Oncology 16 (2) , pp. 122-124. 10.1016/S1470-2045(15)70003-3

Lin, Thet Thet, Norris, Kevin, Heppel, Nicole H., Pratt, Guy, Allan, James M., Allsup, David J., Bailey, James, Cawkwell, Lynn, Hills, Robert ORCID: https://orcid.org/0000-0003-0166-0062, Grimstead, Julia W., Jones, Rhiannon E., Britt-Compton, Bethan, Fegan, Christopher ORCID: https://orcid.org/0000-0001-9685-0621, Baird, Duncan Matrin ORCID: https://orcid.org/0000-0001-8408-5467 and Pepper, Christopher 2014. Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease. British Journal of Haematology 167 (2) , pp. 214-223. 10.1111/bjh.13023

Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Aboraia, Ahmed S., Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Pepper, Christopher J., Zhu, Jinge, Ochalek, Justin T., DeLuca, Hector F. and Simons, Claire ORCID: https://orcid.org/0000-0002-9487-1100 2014. Small-molecule inhibitors of 25-Hydroxyvitamin D-24-Hydroxylase (CYP24A1): synthesis and biological evaluation. Journal of Medicinal Chemistry 57 (18) , pp. 7702-7715. 10.1021/jm5009314

Walsby, Elisabeth ORCID: https://orcid.org/0000-0001-8523-5017, Buggins, Andrea, Devereux, Stephen, Jones, Ceri, Pratt, Guy, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Fegan, Chris ORCID: https://orcid.org/0000-0001-9685-0621 and Pepper, Chris 2014. Development and characterization of a physiologically relevant model of lymphocyte migration in chronic lymphocytic leukemia. Blood 123 (23) , pp. 3607-3617. 10.1182/blood-2013-12-544569

Bulian, Pietro, Shanafelt, Tait D., Fegan, Chris ORCID: https://orcid.org/0000-0001-9685-0621, Zucchetto, Antonella, Cro, Lilla, Nuckel, Holger, Baldini, Luca, Kurtova, Antonia V., Ferrajoli, Alessandra, Burger, Jan A., Gaidano, Gianluca, Del Poeta, Giovanni, Pepper, Chris, Rossi, Davide and Gattei, Valter 2014. CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia. Journal of Clinical Oncology 32 (9) , pp. 897-904. 10.1200/JCO.2013.50.8515

Pepper, Christopher John, Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467 and Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 2014. Telomere analysis to predict chronic lymphocytic leukemia outcome: a STELA test to change clinical practice? Expert Review of Hematology 7 (6) , pp. 701-703. 10.1586/17474086.2014.969705

Alsagaby, Suliman A., Khanna, Sanjay, Hart, Keith, Pratt, Guy, Fegan, Christopher ORCID: https://orcid.org/0000-0001-9685-0621, Pepper, Christopher, Brewis, Ian and Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 2014. Proteomics-based strategies to identify proteins relevant to chronic lymphocytic leukemia. Journal of Proteome Research 13 (11) , pp. 5051-5062. 10.1021/pr5002803

Wong, Ryan Francis, Pepper, Christopher John, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Nagorsen, Dirk, Man, Stephen Tzekwung ORCID: https://orcid.org/0000-0001-9103-1686 and Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 2013. Blinatumomab induces autologous T cell killing of chronic lymphocytic leukemia cells. Haematologica 98 (12) , pp. 1930-1938. 10.3324/haematol.2012.082248

Groves, M., Johnson, Charlotte ORCID: https://orcid.org/0000-0003-1954-5142, James, J., Prescott, A., Cunningham, J., Haydock, S., Pepper, Christopher John, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Pirrie, L., Westwood, N., Coates, P., Ganley, I. and Tauro, S. 2013. p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia. British Journal of Cancer 109 (9) , pp. 2434-2444. 10.1038/bjc.2013.601

Rahman, K., Jackson, P., James, C., Basu, B., Hartley, J., de la Fuente, M., Schatzlein, A., Robson, M., Pedley, R., Pepper, Christopher John, Fox, K., Howard, P. and Thurston, D. 2013. GC-Targeted C8-Linked pyrrolobenzodiazepine biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models. Journal of Medicinal Chemistry 56 (7) , pp. 2911-2935. 10.1021/jm301882a

Walsby, Elisabeth Jane ORCID: https://orcid.org/0000-0001-8523-5017, Lazenby, Michelle, Pepper, Christopher John, Knapper, Steven ORCID: https://orcid.org/0000-0002-6405-4441 and Burnett, Alan Kenneth 2013. The HSP90 inhibitor NVP-AUY922-AG inhibits the PI3K and IKK signalling pathways and synergizes with cytarabine in acute myeloid leukaemia cells. British Journal of Haematology 161 (1) , pp. 57-67. 10.1111/bjh.12215

Shao, H., Shi, S., Huang, S, Hole, A., Abbas, A., Baumli, S., Liu, X., Lam, F., Foley, David ORCID: https://orcid.org/0000-0001-8449-4754, Fischer, P., Noble, M., Endicott, J., Pepper, Christopher John and Wang, S. 2013. Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure activity relationship, and anticancer activities. Journal of Medicinal Chemistry 56 (3) , pp. 640-659. 10.1021/jm301475f

Hole, A., Baumli, S., Shao, H., Shi, S., Huang, S., Pepper, Christopher John, Fischer, P., Wang, S., Endicott, J. and Noble, M. 2013. Comparative structural and functional studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity. Journal of Medicinal Chemistry 56 (3) , pp. 660-670. 10.1021/jm301495v

Hamilton, Emma, Pearce, Laurence, Morgan, Liam ORCID: https://orcid.org/0000-0002-7571-6025, Robinson, Sophie, Ware, Victoria Lesley, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Thomas, N. Shaun B., Yallop, Deborah, Devereux, Stephen, Fegan, Christopher D. ORCID: https://orcid.org/0000-0001-9685-0621, Buggins, Andrea G. S. and Pepper, Christopher John 2012. Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells. British Journal of Haematology 158 (5) , pp. 589-599. 10.1111/j.1365-2141.2012.09191.x

Walsby, Elisabeth Jane ORCID: https://orcid.org/0000-0001-8523-5017, Pearce, Laurence, Burnett, Alan Kenneth, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 and Pepper, Christopher John 2012. The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-κB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells. Oncotarget 3 (5) , pp. 525-534.

Britt-Compton, Bethan, Lin, Thet Thet, Ahmed, G., Weston, V., Robinson, Rhiannon Elizabeth, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Oscier, D. G., Stankovic, T., Pepper, Christopher John and Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467 2012. Extreme telomere erosion in ATM-mutated and 11q-deleted CLL patients is independent of disease stage [Letter]. Leukemia 26 (4) , pp. 826-830. 10.1038/leu.2011.281

Vaisitti, T., Serra, S., Pepper, Christopher John, Rossi, D., Laurenti, L., Gaidano, G., Malavasi, F. and Deaglio, S. 2012. CD38 signals upregulate expression and functions of matrix metalloproteinase-9 in chronic lymphocytic leukemia cells [Letter]. Leukemia 27 (5) , pp. 1177-1181. 10.1038/leu.2012.260

Liu, Xiangrui, Shi, Shenhua, Lam, Frankie, Pepper, Christopher John, Fischer, Peter M. and Wang, Shudong 2012. CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol. International Journal of Cancer 130 (5) , pp. 1216-1226. 10.1002/ijc.26127

Nunes, Claudia Trindade, Wong, Ryan Francis, Mason, Malcolm David ORCID: https://orcid.org/0000-0003-1505-2869, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Man, Stephen Tzekwung ORCID: https://orcid.org/0000-0001-9103-1686 and Pepper, Christopher John 2012. Expansion of a CD8+PD-1+ replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression. Clinical Cancer Research 18 (3) , pp. 678-687. 10.1158/1078-0432.CCR-11-2630

Pepper, Christopher John, Majid, Aneela, Lin, Thet Thet, Hewamana, Saman, Pratt, Guy, Walewska, Renata, Gesk, Stefan, Siebert, Reiner, Wagner, Simon, Kennedy, Ben, Miall, Fiona, Davis, Zadie A., Tracy, Ian, Gardiner, Anne C., Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Dyer, Martin J. S., Oscier, David and Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 2012. Defining the prognosis of early stage chronic lymphocytic leukaemia patients. British Journal of Haematology 156 (4) , pp. 499-507. 10.1111/j.1365-2141.2011.08974.x

Jones, Ceri H., Pepper, Christopher John and Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467 2012. Telomere dysfunction and its role in haematological cancer. British Journal of Haematology 156 (5) , pp. 573-587. 10.1111/j.1365-2141.2011.09022.x

Nunes, Claudia Trindade, Miners, Kelly Louise, Dolton, Garry Michael, Pepper, Christopher John, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Mason, Malcolm David ORCID: https://orcid.org/0000-0003-1505-2869 and Man, Stephen Tzekwung ORCID: https://orcid.org/0000-0001-9103-1686 2011. A novel tumor antigen derived from enhanced degradation of Bax protein in human cancers. Cancer Research 71 (16) , pp. 5435-5444. 10.1158/0008-5472.CAN-11-0393

Walsby, Elisabeth Jane ORCID: https://orcid.org/0000-0001-8523-5017, Lazenby, Michelle, Pepper, Christopher John and Burnett, Alan Kenneth 2011. The cyclin-dependent kinase inhibitor SNS-032 has single agent activity in AML cells and is highly synergistic with cytarabine. Leukemia 25 (3) , pp. 411-419. 10.1038/leu.2010.290

Jenkins, Christopher, Hewamana, Saman, Krige, David, Pepper, Christopher John and Burnett, Alan Kenneth 2011. Aminopeptidase inhibition by the novel agent CHR-2797 (tosedostat) for the therapy of acute myeloid leukemia. Leukemia Research 35 (5) , pp. 677-681. 10.1016/j.leukres.2010.10.030

Pepper, Christopher John, Mahdi, J. G., Buggins, A. G. S., Hewamana, Saman, Walsby, Elisabeth Jane ORCID: https://orcid.org/0000-0001-8523-5017, Mahdi, Eamon, Al-Haza'a, A., Mahdi, Ali J., Lin, Thet Thet, Pearce, Laurence, Morgan, Liam David ORCID: https://orcid.org/0000-0002-7571-6025, Bowen, Ivor D., Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 and Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 2011. Two novel aspirin analogues show selective cytotoxicity in primary chronic lymphocytic leukaemia cells that is associated with dual inhibition of Rel A and COX-2. Cell Proliferation 44 (4) , pp. 380-390. 10.1111/j.1365-2184.2011.00760.x

Majid, Aneela, Lin, Thet Thet, Best, Giles, Fishlock, Keith, Hewamana, Saman, Pratt, Guy, Yallop, Deborah, Buggins, Andrea G. S., Wagner, Simon, Kennedy, Ben J., Miall, Fiona, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Devereux, Stephen, Oscier, David G., Dyer, Martin J. S., Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 and Pepper, Christopher John 2011. CD49d is an independent prognostic marker that is associated with CXCR4 expression in CLL. Leukemia Research 35 (6) , pp. 750-756. 10.1016/j.leukres.2010.10.022

Pepper, Christopher John and Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 2011. CLL: a supplementary question? Blood 117 (5) , pp. 1439-1440. 10.1182/blood-2010-11-318451

Pepper, Christopher John and Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467 2010. Shortened telomeres: a driving force behind leukemia? [Editorial]. Future Oncology 6 (11) , pp. 1681-1686. 10.2217/fon.10.135

Buggins, Andrea G. S., Pepper, Christopher John, Patten, Piers E. M., Hewamana, Saman, Gohil, Satyen, Moorhead, Jane, Folarin, Najeem'deen, Yallop, Deborah, Thomas, N. Shaun B., Mufti, Ghulam J., Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 and Devereux, Stephen 2010. Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-κB activation and De novo gene transcription. Cancer Research 70 (19) , pp. 7523-7534. 10.1158/0008-5472.CAN-10-1634

Lin, Thet Thet, Letsolo, Boitelo Theresiah, Robinson, Rhiannon Elizabeth, Rowson, Janet Maud, Pratt, Guy, Hewamana, Saman, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Pepper, Christopher John and Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467 2010. Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis. Blood 116 (11) , pp. 1899-1907. 10.1182/blood-2010-02-272104

Hartley, John A., Hamaguchi, Anzu, Coffils, Marissa, Martin, Christopher R. H., Suggitt, Marie, Chen, Zhizhi, Gregson, Stephen J., Masterson, Luke A., Tiberghien, Arnaud C., Hartley, Janet M., Pepper, Christopher John, Lin, Thet Thet, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Thurston, David E. and Howard, Philip W. 2010. SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer prodrug that cross-links DNA and exerts highly potent antitumor activity. Cancer Research 70 (17) , pp. 6849-6859. 10.1158/0008-5472.CAN-10-0790

Pearce, Laurence, Morgan, Liam David ORCID: https://orcid.org/0000-0002-7571-6025, Lin, Thet Thet, Hewamana, Saman, Matthews, Reginald James, Deaglio, Silvia, Rowntree, Clare, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Pepper, Christopher John and Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 2010. Genetic modification of primary chronic lymphocytic leukemia cells with a lentivirus expressing CD38. Haematologica 95 (3) , pp. 514-517. 10.3324/haematol.2009.014381

Walsby, Elisabeth Jane ORCID: https://orcid.org/0000-0001-8523-5017, Pratt, G., Hewamana, Saman, Crooks, P. A., Burnett, Alan Kenneth, Fegan, Christopher Daniel. ORCID: https://orcid.org/0000-0001-9685-0621 and Pepper, Christopher John 2010. The NF- B inhibitor LC-1 has single agent activity in multiple myeloma cells and synergizes with bortezomib. Molecular Cancer Therapeutics 9 (6) , pp. 1574-1582. 10.1158/1535-7163.MCT-10-0104

Pepper, Christopher John 2010. Targeting the "partners in crime". Blood 116 (1) , pp. 3-4. 10.1182/blood-2010-04-278499

Vaisitti, T., Aydin, S., Rossi, D., Cottino, F., Bergui, L., D'Arena, G., Bonello, L., Horenstein, A. L., Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Pepper, Christopher John, Gaidano, G., Malavasi, F. and Deaglio, S. 2010. CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells. Leukemia 24 (5) , pp. 958-969. 10.1038/leu.2010.36

Allan, J. M., Sunter, N. J., Bailey, J. R., Pettitt, A. R., Harris, R. J., Pepper, Christopher John, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Hall, A. G., Deignan, L, Bacon, C. M., Pointon, J. C., Houlston, R. S., Broderick, P, Mainou-Fowler, T, Jackson, G. H., Summerfield, G, Evans, P. A., Strefford, J. C., Parker, A, Oscier, D, Pratt, G and Allsup, D. J. 2010. Variant IRF4/MUM1 associates with CD38 status and treatment-free survival in chronic lymphocytic leukaemia [Letter]. Leukemia 24 (4) , pp. 877-881. 10.1038/leu.2009.298

Crowther-Swanepoel, Dalemari, Broderick, Peter, Di Bernardo, Maria Chiara, Dobbins, Sara E., Torres, María, Mansouri, Mahmoud, Ruiz-Ponte, Clara, Enjuanes, Anna, Rosenquist, Richard, Carracedo, Angel, Jurlander, Jesper, Campo, Elias, Juliusson, Gunnar, Montserrat, Emilio, Smedby, Karin E., Dyer, Martin J. S., Matutes, Estella, Dearden, Claire, Sunter, Nicola J., Hall, Andrew G., Mainou-Fowler, Tryfonia, Jackson, Graham H., Summerfield, Geoffrey, Harris, Robert J., Pettitt, Andrew R., Allsup, David J., Bailey, James R., Pratt, Guy, Pepper, Christopher John, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Parker, Anton, Oscier, David, Allan, James M., Catovsky, Daniel and Houlston, Richard S. 2010. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. Nature Genetics 42 (2) , pp. 132-136. 10.1038/ng.510

Pepper, Christopher John, Hewamana, Saman, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 and Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 2009. NF-κB as a prognostic marker and therapeutic target in chronic lymphocytic leukemia. Future Oncology 5 (7) , pp. 1027-1037. 10.2217/fon.09.72

Roberts, Gareth W., Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467, Gallagher, Kathleen M. E., Robinson, Rhiannon Elizabeth, Pepper, Christopher John, Williams, John David and Topley, Nicholas 2009. Functional effector memory T cells enrich the peritoneal cavity of patients treated with peritoneal dialysis. Journal of the American Society of Nephrology 20 (9) , pp. 1895-1900. 10.1681/ASN.2008101127

Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Shore, Angharad M., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Hewamana, Saman, Jones, Catrin M., Giles, Peter James ORCID: https://orcid.org/0000-0003-3143-6854, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Pepper, Christopher John and Brewis, Ian Andrew 2009. Quantitative nuclear proteomics reveals new phenotypes altered in lymphoblastoid cells. Proteomics - Clinical Applications 3 (3) , pp. 359-369. 10.1002/prca.200800137

Hewamana, Saman, Lin, Thet Thet, Rowntree, Clare, Karunanithi, Kamaraj, Pratt, Guy, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 and Pepper, Christopher John 2009. Rel A is an independent biomarker of clinical outcome in chronic lymphocytic leukemia. Journal of Clinical Oncology 27 (5) , pp. 763-769. 10.1200/JCO.2008.19.1114

Delgado, Julio, Pratt, Guy, Phillips, Neil, Briones, Javier, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Nomdedeu, Josep, Pepper, Christopher John, Aventin, Anna, Ayats, Ramon, Brunet, Salut, Martino, Rodrigo, Valcarcel, David, Milligan, Donald and Sierra, Jorge 2009. Beta2-microglobulin is a better predictor of treatment-free survival in patients with chronic lymphocytic leukaemia if adjusted according to glomerular filtration rate. British Journal of Haematology 145 (6) , pp. 801-805. 10.1111/j.1365-2141.2009.07699.x

Pratt, Guy, Harding, Stephen, Holder, Roger, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Pepper, Christopher John, Oscier, David, Gardiner, Anne, Bradwell, Arthur R. and Mead, Graham 2009. Abnormal serum free light chain ratios are associated with poor survival and may reflect biological subgroups in patients with chronic lymphocytic leukaemia. British Journal of Haematology 144 (2) , pp. 217-222. 10.1111/j.1365-2141.2008.07456.x

Pepper, Christopher John 2009. APRIL showers put a spring in the step of CLL cells [Editorial]. Leukemia Research 33 (10) , pp. 1306-1307. 10.1016/j.leukres.2009.04.031

Hewamana, Saman, Pepper, Christopher John, Jenkins, Chris and Rowntree, Clare 2009. Acute renal failure as the presenting feature of leukaemic infiltration in chronic lymphocytic leukaemia. Clinical and Experimental Nephrology 13 (2) , pp. 179-181. 10.1007/s10157-009-0129-y

Hewamana, Saman, Pepper, Christopher John, Karunanithi, Kamaraj, Jenkins, Christopher and Rowntree, Clare 2009. Durable response to a single dose of Anti D in immune thrombocytopenic purpura in an adult with underlying human immunodeficiency viral infection [Letter]. Annals of Hematology 88 (11) , pp. 1155-1156. 10.1007/s00277-009-0744-4

Hewamana, Saman, Lin, Thet Thet, Jenkins, Chris, Burnett, Alan Kenneth, Jordan, Craig T., Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Rowntree, Clare and Pepper, Christopher John 2008. The novel nuclear factor- B inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabine. Clinical Cancer Research 14 (24) , pp. 8102-8111. 10.1158/1078-0432.CCR-08-1673

Pepper, Christopher John, Lin, Thet Thet, Pratt, Guy, Hewamana, Saman, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Hiller, Louise, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Ward, Rachel, Starczynski, Jane, Austen, Belinda, Hooper, Laura, Stankovic, Tatjana and Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 2008. Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers. Blood 112 (9) , pp. 3807-3817. 10.1182/blood-2008-05-157131

Hewamana, Saman, Alghazal, Suhair Alkailani, Lin, Thet Thet, Clement, Matthew ORCID: https://orcid.org/0000-0002-9280-5281, Jenkins, Christopher, Guzman, Monica L., Jordan, Craig T., Neelakantan, Sundar, Crooks, Peter A., Burnett, Alan Kenneth, Pratt, Guy, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Rowntree, Clare, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 and Pepper, Christopher John 2008. The NF-κB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target. Blood 111 (9) , pp. 4681-4689. 10.1182/blood-2007-11-125278

Lin, Thet Thet, Hewamana, Saman, Ward, Rachel Mary, Taylor, Hannah, Payne, Tammy, Pratt, Guy, Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467, Fegan, Christopher D. ORCID: https://orcid.org/0000-0001-9685-0621 and Pepper, Christopher John 2008. Highly purified CD38+ sub-populations show no evidence of preferential clonal evolution despite having increased proliferative activity when compared with CD38+ sub-populations derived from the same chronic lymphocytic leukaemia patient. British Journal of Haematology 142 (4) , pp. 595-605. 10.1111/j.1365-2141.2008.07236.x

Jenkins, Christopher, Hewamana, Saman, Gilkes, Amanda F., Neelakantan, Sundar, Crooks, Peter, Mills, Ken, Pepper, Christopher John and Burnett, Alan Kenneth 2008. Nuclear factor-kappaB as a potential therapeutic target for the novel cytotoxic agent LC-1 in acute myeloid leukaemia. British Journal of Haematology 143 (5) , pp. 661-671. 10.1111/j.1365-2141.2008.07392.x

Pepper, Christopher John 2008. Suppressing the tumor suppressor in CLL? Blood 112 (9) , pp. 3537-3538. 10.1182/blood-2008-08-175042

Walsby, Elisabeth Jane ORCID: https://orcid.org/0000-0001-8523-5017, Walsh, Val, Pepper, Christopher John, Burnett, Alan Kenneth and Mills, Ken 2008. Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts. Haematologica 93 (5) , pp. 662-669. 10.3324/haematol.12148

Di Bernardo, Maria Chiara, Crowther-Swanepoel, Dalemari, Broderick, Peter, Webb, Emily, Sellick, Gabrielle, Wild, Ruth, Sullivan, Kate, Vijayakrishnan, Jayaram, Wang, Yufei, Pittman, Alan M, Sunter, Nicola J, Hall, Andrew G, Dyer, Martin J S, Matutes, Estella, Dearden, Claire, Mainou-Fowler, Tryfonia, Jackson, Graham H, Summerfield, Geoffrey, Harris, Robert J, Pettitt, Andrew R, Hillmen, Peter, Allsup, David J, Bailey, James R, Pratt, Guy, Pepper, Christopher John, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Allan, James M, Catovsky, Daniel and Houlston, Richard S 2008. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia [Letter]. Nature Genetics 40 (10) , pp. 1204-1210. 10.1038/ng.219

Hewamana, Saman, Pepper, Christopher John, Couzens, Stephen, Thomas, Alun and Knapper, Steven ORCID: https://orcid.org/0000-0002-6405-4441 2008. IgM multiple myeloma: a diagnostic challenge in a patient with coexisting chronic lymphocytic leukaemia. International Journal of Hematology 88 (4) , pp. 424-427. 10.1007/s12185-008-0179-z

Milroy, L. G., Zinzalla, G., Loiseau, F., Qian, Z., Prencipe, G., Pepper, Christopher John, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 and Ley, S. V. 2008. Natural-product-like spiroketals and fused bicyclic acetals as potential therapeutic agents for B-cell chronic lymphocytic leukaemia. ChemMedChem 3 (12) , pp. 1922-1935. 10.1002/cmdc.200800265

Pepper, Christopher John, Ward, R., Lin, Thet Thet, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Starczynski, J., Musson, M., Rowntree, Claire, Bentley, P., Mills, K., Pratt, G. and Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 2007. Highly purified CD38+ and CD38- sub-clones derived from the same chronic lymphocytic leukemia patient have distinct gene expression signatures despite their monoclonal origin. Leukemia 21 (4) , pp. 687-696. 10.1038/sj.leu.2404587

George, Christopher H., Rogers, Sarah Ann, Bertrand, Benedicte M.A., Tunwell, Richard E.A., Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Steele, Derek S., Cox, Eryl Vanessa, Pepper, Christopher John, Hazeel, Carolyn Jean, Claycomb, William C. and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2007. Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signalling and susceptibility to apoptosis. Circulation Research 100 (6) , pp. 874-883. 10.1161/01.RES.0000260804.77807.cf

Pepper, Christopher John, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Alghazal, S., Ward, R., Pratt, G., Starczynski, J., Lin, Thet Thet and Rowntree, C. 2006. CD38+ chronic lymphocytic leukaemia cells co-express high levels of ZAP-70 and are functionally distinct from their CD38− counter-parts. Leukemia 20 (4) , pp. 743-744. 10.1038/sj.leu.2404133

Khanna, Sanjay, Hudson, Benjamin, Pepper, Christopher John, Amso, Nazar Najib ORCID: https://orcid.org/0000-0002-8646-6623 and Coakley, William Terence 2006. Fluorescein isothiocynate-dextran uptake by chinese hamster ovary cells in a 1.5 mhz ultrasonic standing wave in the presence of contrast agent. Ultrasound in Medicine & Biology 32 (2) , pp. 289-295. 10.1016/j.ultrasmedbio.2005.11.002

Starczynski, Jane, Pepper, Christopher John, Pratt, Guy, Hooper, Laura, Thomas, Alun, Milligan, Donald, Bentley, Paul and Fegan, Christopher D. 2005. Common polymorphism G(-248)A in the promoter region of the bax gene results in significantly shorter survival in patients with chronic lymphocytic Leukemia once treatment is initiated. Journal of Clinical Oncology 23 (7) , pp. 1514-1521. 10.1200/JCO.2005.02.192

Pepper, Christopher John, Hambly, Rachel M., Fegan, Christopher D., Delavault, Patrick and Thurston, David E. 2004. The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill. Cancer Research 64 (18) , pp. 6750-6755. 10.1158/0008-5472.CAN-04-1713

Pepper, Christopher John, Thomas, Alun, Hoy, Terence George, Milligan, Donald, Bentley, Paul and Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 2003. The vitamin D3 analog EB1089 induces apoptosis via a p53-independent mechanism involving p38 MAP kinase activation and suppression of ERK activity in B-cell chronic lymphocytic leukemia cells in vitro. Blood 101 (7) , pp. 2454-2460. 10.1182/blood-2002-07-1984

Pepper, Christopher John, Thomas, Alun, Hoy, Terence George, Tighe, Jane, Culligan, Dominic, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 and Bentley, Paul 2003. Leukemic and non-leukemic lymphocytes from patients with Li Fraumeni syndrome demonstrate loss of p53 function, Bcl-2 family dysregulation and intrinsic resistance to conventional chemotherapeutic drugs but not flavopiridol. Cell Cycle 2 (1) , pp. 53-8.