Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Frizzled7 activates β-catenin-dependent and β-catenin-independent Wnt signalling pathways during developmental morphogenesis: implications for therapeutic targeting in colorectal cancer

Tran, Bang Manh, Flanagan, Dustin James, Phesse, Toby James, Vincan, Elizabeth and Phesse, Toby 2021. Frizzled7 activates β-catenin-dependent and β-catenin-independent Wnt signalling pathways during developmental morphogenesis: implications for therapeutic targeting in colorectal cancer. Handbook of Experimental Pharmacology,

Full text not available from this repository.

Abstract

Frizzled7 activates β-catenin-dependent and β-catenin-independent Wnt signalling pathways, is highly conserved through evolution from the ancient phylum hydra to man, plays essential roles in stem cells, tissue homeostasis and regeneration in the adult, and is upregulated in diverse cancers. Much of what is known about the core components of the Wnt signalling pathways was derived from studying the function of Frizzled7 orthologues in the development of lower organism. As we interrogate Frizzled7 signalling and function for therapeutic targeting in cancer, it is timely to revisit lower organisms to gain insight into the context dependent and dynamic nature of Wnt signalling for effective drug design.

Item Type: Book Section
Date Type: Publication
Status: In Press
Schools: Biosciences
European Cancer Stem Cell Research Institute (ECSCRI)
Date of First Compliant Deposit: 15 September 2021
Last Modified: 21 Sep 2021 09:29
URI: http://orca.cardiff.ac.uk/id/eprint/144129

Actions (repository staff only)

Edit Item Edit Item