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Number of items: 47.

Badder, Luned, Davies, James ORCID: https://orcid.org/0000-0003-3569-4500, Meniel, Valerie, Maruskova, Mahulena, Salvador, Beatriz, Bayliss, Rebecca ORCID: https://orcid.org/0000-0002-3324-957X, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Hogan, Catherine ORCID: https://orcid.org/0000-0002-1012-0896 and Parker, Alan ORCID: https://orcid.org/0000-0002-9302-1761 2024. The αvβ6 integrin specific virotherapy, Ad5NULL-A20.FCU1, selectively delivers 2 potent “in-tumour” chemotherapy to Pancreatic Ductal Adenocarcinoma. British Journal of Cancer 131 , pp. 1694-1706. 10.1038/s41416-024-02869-3
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Turnham, Daniel J. ORCID: https://orcid.org/0000-0002-2540-7363, Mullen, Manisha S., Bullock, Nicholas P., Gilroy, Kathryn L., Richards, Anna E., Patel, Radhika, Quintela, Marcos, Meniel, Valerie S., Seaton, Gillian, Kynaston, Howard ORCID: https://orcid.org/0000-0003-1902-9930, Clarkson, Richard W. E. ORCID: https://orcid.org/0000-0001-7389-8673, Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916, Nelson, Peter S., Haffner, Michael C., Staffurth, John N. ORCID: https://orcid.org/0000-0002-7834-3172 and Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843 2024. Development and characterisation of a new patient-derived Xenograft model of AR-negative metastatic asctration-resistant prostate cancer. Cells 13 (8) , 673. 10.3390/cells13080673
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Routledge, Daniel, Rogers, Sally, Ono, Yosuke, Brunt, Lucy, Meniel, Valerie, Tornillo, Giusy, Ashktorab, Hassan, Phesse, Toby J ORCID: https://orcid.org/0000-0001-9568-4916 and Scholpp, Steffen 2022. The scaffolding protein flot2 promotes cytoneme-based transport of wnt3 in gastric cancer. eLife 11 , e77376. 10.7554/elife.77376
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Bates, Emily A., Davies, James A. ORCID: https://orcid.org/0000-0003-3569-4500, Vánová, Jana, Nestic, Davor, Meniel, Valerie S., Koushyar, Sarah, Cunliffe, Tabitha G., Mundy, Rosie M., Moses, Elise, Uusi-Kerttula, Hanni K., Baker, Alexander T. ORCID: https://orcid.org/0000-0001-8232-0531, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Majhen, Dragomira, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Chester, John D. ORCID: https://orcid.org/0000-0002-7830-3840 and Parker, Alan L. ORCID: https://orcid.org/0000-0002-9302-1761 2022. Development of a low seroprevalence, αvβ6 integrin selective virotherapy based on human adenovirus type 10. Molecular Therapy - Oncolytics 25 , pp. 43-56. 10.1016/j.omto.2022.03.007
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Koushyar, Sarah, Meniel, Valerie S., Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916 and Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843 2022. Exploring the Wnt pathway as a therapeutic target for prostate cancer. Biomolecules 12 (2) , 309. 10.3390/biom12020309
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Tran, Bang Manh, Flanagan, Dustin James, Phesse, Toby James ORCID: https://orcid.org/0000-0001-9568-4916, Vincan, Elizabeth and Phesse, Toby 2021. Frizzled7 activates β-catenin-dependent and β-catenin-independent Wnt signalling pathways during developmental morphogenesis: implications for therapeutic targeting in colorectal cancer. Handbook of Experimental Pharmacology,

Jardé, Thierry, Chan, Wing Hei, Rossello, Fernando J., Kaur Kahlon, Tanvir, Theocharous, Mandy, Kurian Arackal, Teni, Flores, Tracey, Giraud, Mégane, Richards, Elizabeth, Chan, Eva, Kerr, Genevieve, Engel, Rebekah M., Prasko, Mirsada, Donoghue, Jacqueline F., Abe, Shin-ichi, Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916, Nefzger, Christian M., McMurrick, Paul J., Powell, David R., Daly, Roger J., Polo, Jose M. and Abud, Helen E. 2020. Mesenchymal niche-derived neuregulin-1 drives intestinal stem cell proliferation and regeneration of damaged epithelium. Cell Stem Cell 27 (4) , 646-662.E7. 10.1016/j.stem.2020.06.021
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Tran, Bang Manh, Flanagan, Dustin James, Ebert, Gregor, Warner, Nadia, Tran, Hoanh, Fifis, Theodora, Kastrappis, Georgios, Christophi, Christopher, Pellegrini, Marc, Torresi, Joseph, Phesse, Toby James ORCID: https://orcid.org/0000-0001-9568-4916 and Vincan, Elizabeth 2020. The hepatitis B virus pre-core protein p22 activates Wnt sgnaling. Cancers 12 (6) , 1435. 10.3390/cancers12061435
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Koushyar, Sarah, Powell, Arfon G. ORCID: https://orcid.org/0000-0002-3740-8275, Vincan, Elizabeth and Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916 2020. Targeting Wnt signaling for the treatment of gastric cancer. International Journal of Molecular Sciences 21 (11) , 3927. 10.3390/ijms21113927
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Flanagan, Dustin J, Vincan, Elizabeth and Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916 2019. Wnt signaling in cancer: not a binary ON:OFF switch. Cancer Research 10.1158/0008-5472.CAN-19-1362
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Parry, Lee ORCID: https://orcid.org/0000-0002-4467-9196 and Phesse, Toby J ORCID: https://orcid.org/0000-0001-9568-4916 2019. FXR regulates intestinal stem cells response to bile acids in a high fat diet. Biotarget 3 (12) 10.21037/biotarget.2019.07.01
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Flanagan, Dustin, Barker, Nick, Ernst, Matthias, Vincan, Elizabeth and Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916 2019. The function of Lgr5+ cells in the gastric antrum does not require Fzd7 or Myc in vivo. Biomedicines 7 (3) , 50. 10.3390/biomedicines7030050
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Flanagan, Dustin J., Barker, Nick, Di Costanzo, Natasha S., Mason, Elizabeth A., Gurney, Austin, Meniel, Valerie S., Koushyar, Sarah, Austin, Chloe R., Ernst, Matthias, Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Boussioutas, Alex, Clevers, Hans, Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916 and Vincan, Elizabeth 2019. Frizzled-7 is required for Wnt signaling in gastric tumours with and without Apc mutations. Cancer Research 79 (5) , pp. 970-981. 10.1158/0008-5472.CAN-18-2095
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Eissman, Moritz F, Dijkstra, Christine, Jarnicki, Andrew, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Brunnberg, Jamina, Poh, Ashleigh R, Etemadi, Nima, Tsantikos, Evelyn, Thiem, Stefan, Huntington, Nicholas H, Hibbs, Margaret L, Boussioutas, Alex, Grimbaldeston, Michele A, Buchert, Michael, O'Donoghue, Robert J J, Masson, Frederick and Ernst, Matthias 2019. IL-33 mediated mast cell activation promotes gastric cancer through macrophage mobilization. Nature Communications 10 , 2735. 10.1038/s41467-019-10676-1
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Greenow, Kristy R., Zverev, Matthew, May, Stephanie, Kendrick, Howard, Williams, Geraint T. ORCID: https://orcid.org/0000-0003-3768-9940, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916 and Parry, Lee ORCID: https://orcid.org/0000-0002-4467-9196 2018. Lect2 deficiency is characterised by altered cytokine levels and promotion of intestinal tumourigenesis. Oncotarget 9 (92) , pp. 36430-36443. 10.18632/oncotarget.26335
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May, Stephanie, Owen, Heather, Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916, Greenow, Kristy R., Jones, Gareth-Rhys, Blackwood, Adam, Cook, Peter C., Towers, Christopher, Gallimore, Awen M. ORCID: https://orcid.org/0000-0001-6675-7004, Williams, Geraint T., Sturzl, Michael, Britzen-Laurent, Nathalie, Sansom, Owen J., MacDonald, Andrew S., Bird, Adrian P., Clarke, Alan R. and Parry, Lee ORCID: https://orcid.org/0000-0002-4467-9196 2018. Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation. Journal of Pathology 245 (3) , pp. 270-282. 10.1002/path.5074
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Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Li, Jason, Meniel, Valerie S., Fennell, Christina M., Waring, Paul, Montgomery, Karen G., Rebello, Richard J., Macpherson, Arthi A., Koushyar, Sarah, Furic, Luc, Cullinane, Carleen, Clarkson, Richard W. ORCID: https://orcid.org/0000-0001-7389-8673, Smalley, Matthew J. ORCID: https://orcid.org/0000-0001-9540-1146, Simpson, Kaylene J., Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916, Shepherd, Peter R., Humbert, Patrick O., Sansom, Owen J. and Phillips, Wayne A. 2018. Identification of Pik3ca mutation as a genetic driver of prostate cancer that cooperates with Pten loss to accelerate progression and castration-resistant growth. Cancer Discovery 8 (6) , pp. 764-779. 10.1158/2159-8290.CD-17-0867
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Flanagan, Dustin, Austin, Chloe, Vincan, Elizabeth and Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916 2018. Wnt Signalling in gastrointestinal epithelial stem cells. Genes 9 (4) , 178. 10.3390/genes9040178
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Vincan, Elizabeth, Schwab, Renate H.M., Flanagan, Dustin J., Moselen, Jean M., Tran, Bang M., Barker, Nick and Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916 2018. The central role of Wnt signaling and organoid technology in personalizing anticancer therapy. Progress in Molecular Biology and Translational Science 153 , pp. 299-319. 10.1016/bs.pmbts.2017.11.009
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Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Marsh Durban, Victoria and Sansom, Owen J. 2017. Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models. Carcinogenesis 38 (10) , pp. 953-965. 10.1093/carcin/bgx080
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Flanagan, Dustin J., Barker, Nick, Nowell, Cameron, Clevers, Hans, Ernst, Matthias, Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916 and Vincan, Elizabeth 2017. Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo. Disease Models and Mechanisms 10 (8) , pp. 971-980. 10.1242/dmm.029876
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Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916 and Sansom, Owen J. 2017. Lgr5 joins the club of gastric stem cell markers in the corpus. Nature Cell Biology 19 (7) , pp. 752-754. 10.1038/ncb3567
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Flanagan, Dustin J, Vincan, Elizabeth and Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916 2017. Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers. British Journal of Pharmacology 174 (24) , pp. 4666-4683. 10.1111/bph.13890
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Schwab, Renate H.M., Amin, Nancy, Flanagan, Dustin J., Johanson, Timothy M., Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916 and Vincan, Elizabeth 2017. Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells. Developmental Dynamics 247 (3) , pp. 521-530. 10.1002/dvdy.24527
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Flanagan, Dustin J., Schwab, Renate H. M., Tran, Bang M., Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916 and Vincan, Elizabeth 2016. Isolation and culture of adult intestinal, gastric, and lver organoids for cre-recombinase-mediated gene deletion. Methods in Molecular Biology, Humana Press, pp. 1-11. (10.1007/7651_2016_14)
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Togel, L., Nightingale, R.-, Chueh, A.. C., Jayachandran, A., Tran, Huynh, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Wu, R., Sieber, O. M., Arango, D., Dhillon, A. S., Dawson, M. A., Diez-Dacal, B., Gahman, T. C., Filippakopoulos, P., Shiau, A. K. and Mariadason, J. M. 2016. Dual targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells. Molecular Cancer Therapeutics 15 (6) , pp. 1217-1226. 10.1158/1535-7163.MCT-15-0724

Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Flanagan, Dustin and Vincan, Elizabeth 2016. Frizzled7: a promising achilles' heel for targeting the Wnt receptor complex to treat cancer. Cancers 8 (5) , p. 50. 10.3390/cancers8050050
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Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, McGlinn, Edwina, Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916, Schlüter, Holger, Srikumar, Anuratha, Gödde, Nathan J., Woelwer, Christina B., Ryan, Andrew, Phillips, Wayne A., Ernst, Matthias, Kaur, Pritinder and Humbert, Patrick 2015. The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis. Molecular Cancer 14 , 169. 10.1186/s12943-015-0440-z
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Flanagan, Dustin J., Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916, Barker, Nick, Schwab, Renate H. M., Amin, Nancy, Malaterre, Jordane, Stange, Daniel E., Nowell, Cameron J., Currie, Scott A., Saw, Jarel T. S., Beuchert, Eva, Ramsay, Robert G., Sansom, Owen J., Ernst, Matthias, Clevers, Hans and Vincan, Elizabeth 2015. Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5+ stem cells. Stem Cell Reports 4 (5) , pp. 759-767. 10.1016/j.stemcr.2015.03.003
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Elsum, I. A., Yates, L. L., Pearson, H. B. ORCID: https://orcid.org/0000-0002-3284-0843, Phesse, T. J. ORCID: https://orcid.org/0000-0001-9568-4916, Long, F., O'Donoghue, R., Ernst, M., Cullinane, C. and Humbert, P. O. 2014. Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo. Oncogene 33 (48) , pp. 5523-5533. 10.1038/onc.2013.498

Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916, Buchert, Michael, Stuart, Emma, Flanagan, Dustin J., Faux, Maree, Afshar-Sterle, Shoukat, Walker, Francesca, Zhang, Hui-Hua, Nowell, Cameron J., Jorissen, Robert, Tan, Chin Wee, Hirokawa, Yumiko, Eissmann, Moritz F., Poh, Ashleigh R., Malaterre, Jordane, Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Kirsch, David G., Provero, Paolo, Poli, Valeria, Ramsay, Robert G., Sieber, Oliver, Burgess, Antony W., Huszar, Dennis, Vincan, Elizabeth and Ernst, Matthias 2014. Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt–β-catenin–mediated intestinal tumor growth and regeneration. Science Signaling 7 (345) , ra92. 10.1126/scisignal.2005411

Infantino, S., Jones, S. A., Walker, J. A., Maxwell, M. J., Light, A., O'Donnell, K., Tsantikos, E., Peperzak, V., Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Ernst, M., Mackay, F., Hibbs, M. L., Fairfax, K. A. and Tarlinton, D. M. 2014. The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice. Science Signaling 7 (338) , ra77. 10.1126/scisignal.2005105

Phesse, T. J. ORCID: https://orcid.org/0000-0001-9568-4916, Myant, K. B., Cole, A. M., Ridgway, R. A., Pearson, H. ORCID: https://orcid.org/0000-0002-3284-0843, Muncan, V., van den Brink, G. R., Vousden, K. H., Sears, R., Vassilev, L . T ., Clarke, A. R. ORCID: https://orcid.org/0000-0002-4281-426X and Sansom, O. J. 2014. Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo. Cell Death and Differentiation 21 (6) , pp. 956-966. 10.1038/cdd.2014.15
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Rickard, James A., O'Donnell, Joanne A., Evans, Joseph M., Lalaoui, Najoua, Poh, Ashleigh R., Rogers, TeWhiti, Vince, James E., Lawlor, Kate E., Ninnis, Robert L., Anderton, Holly, Hall, Cathrine, Spall, Sukhdeep K., Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Abud, Helen E., Cengia, Louise H., Corbin, Jason, Mifsud, Sandra, Di Rago, Ladina, Metcalf, Donald, Ernst, Matthias, Dewson, Grant, Roberts, Andrew W., Alexander, Warren S., Murphy, James M., Ekert, Paul G., Masters, Seth L., Vaux, David L., Croker, Ben A., Gerlic, Motti and Silke, John 2014. RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis. Cell 157 (5) , pp. 1175-1188. 10.1016/j.cell.2014.04.019

Hare, Lauren M., Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Waring, Paul M., Montgomery, Karen G., Kinross, Kathryn M., Mills, Kevin, Roh, Vincent, Heath, Joan K., Ramsay, Robert G., Ernst, Matthias and Phillips, Wayne A. 2014. Physiological expression of the PI3K-activating mutationPik3caH1047Rcombines withApcloss to promote development of invasive intestinal adenocarcinomas in mice. Biochemical Journal 458 (2) , pp. 251-258. 10.1042/BJ20131412

Stuart, E., Buchert, M., Putoczki, T., Thiem, S., Farid, R., Elzer, J., Huszar, D., Waring, P. M., Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916 and Ernst, M. 2014. Therapeutic inhibition of jak activity inhibits progression of gastrointestinal tumors in mice. Molecular Cancer Therapeutics 13 (2) , p. 468. 10.1158/1535-7163.MCT-13-0583-T

Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916 and Sansom, Owen J. 2013. Responding to R-spondin: slit2 potentiates intestinal regeneration. Cell Stem Cell 13 , pp. 512-514. 10.1016/j.stem.2013.10.006
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Meniel, Valerie, Song, Fei, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Young, Madeleine, Poetz, Oliver, Parry, Lee ORCID: https://orcid.org/0000-0002-4467-9196, Jenkins, John R., Williams, Geraint Trefor ORCID: https://orcid.org/0000-0003-3768-9940, Dunwoodie, Sally L., Watson, Alastair and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2013. Cited1 deficiency suppresses intestinal tumorigenesis. PLoS Genetics 9 (8) , e1003638. 10.1371/journal.pgen.1003638
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Sakthianandeswaren, A., Christie, M., D'Andreti, C., Tsui, C., Jorissen, R. N., Li, S., Fleming, N. I., Gibbs, P., Lipton, L., Malaterre, J., Ramsay, R. G., Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Ernst, M., Jeffery, R. E., Poulsom, R., Leedham, S. J., Segditsas, S., Tomlinson, I. P. M., Bernhard, O. K., Simpson, R. J., Walker, F., Faux, M. C., Church, N., Catimel, B., Flanagan, D. J., Vincan, E. and Sieber, O. M. 2011. PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis. Cancer Research 71 (10) , pp. 3709-3719. 10.1158/0008-5472.CAN-10-2342

Ashton, Gabrielle H., Morton, Jennifer P., Myant, Kevin, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Ridgway, Rachel A., Marsh Durban, Victoria ORCID: https://orcid.org/0000-0003-1645-1618, Wilkins, Julie A., Athineos, Dimitris, Muncan, Vanesa, Kemp, Richard, Neufeld, Kristi, Clevers, Hans, Brunton, Valerie, Winton, Douglas J., Wang, Xiaoyan, Sears, Rosalie C., Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X, Frame, Margaret C. and Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 2010. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Developmental Cell 19 (2) , pp. 259-269. 10.1016/j.devcel.2010.07.015

Burke, Zoé D., Reed, Karen Ruth ORCID: https://orcid.org/0000-0002-7467-1718, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010, Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X and Tosh, David 2009. Liver zonation occurs through a β-catenin–dependent, c-Myc–independent mechanism. Gastroenterology 136 (7) , pp. 2316-2324. 10.1053/j.gastro.2009.02.063

Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916 and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2009. K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse. Cancer Research 69 (1) , pp. 94-101. 10.1158/0008-5472.CAN-08-2895

Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916 and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2009. Normal stem cells in cancer prone epithelial tissues. British Journal of Cancer 100 (2) , pp. 221-227. 10.1038/sj.bjc.6604850

Bollrath, Julia, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, von Burstin, Vivian A., Putoczki, Tracy, Bennecke, Moritz, Bateman, Trudie, Nebelsiek, Tim, Lundgren-May, Therese, Canli, Özge, Schwitalla, Sarah, Matthews, Vance, Schmid, Roland M., Kirchner, Thomas, Arkan, Melek C., Ernst, Matthias and Greten, Florian R. 2009. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 15 (2) , pp. 91-102. 10.1016/j.ccr.2009.01.002
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Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Parry, Lee ORCID: https://orcid.org/0000-0002-4467-9196, Reed, Karen Ruth ORCID: https://orcid.org/0000-0002-7467-1718, Ewan, Kenneth Burnside Ramsay ORCID: https://orcid.org/0000-0001-6622-9009, Dale, Trevor Clive ORCID: https://orcid.org/0000-0002-4880-9963, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2008. Deficiency of Mbd2 attenuates Wnt induced tumourigenesis via deregulation of a novel Wnt inhibitor, Lect.2. Molecular and Cellular Biology 28 (19) , pp. 6094-6103. 10.1128/MCB.00539-08

Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010, Meniel, Valerie, Muncan, Vanesa, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Wilkins, Julie Ann, Reed, Karen Ruth ORCID: https://orcid.org/0000-0002-7467-1718, Vass, Keith, Athineos, Dimitris, Clevers, Hans and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2007. Myc deletion rescues Apc deficiency in the small intestine. Nature 446 (7136) , pp. 676-679. 10.1038/nature05674

Muncan, Vanesa, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010, Tertoolen, Leon, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Begthel, Harry, Sancho, Elena, Cole, Alicia M., Gregorieff, Alex, de Alboran, Ignacio Moreno, Clevers, Hans and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2006. Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Molecular and Cellular Biology 26 (22) , pp. 8418-8426. 10.1128/MCB.00821-06
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