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Gemcitabine Prodrugs

NuCana PLC 2015. Gemcitabine Prodrugs. WO 2015/198058; GB51857. [Patent].

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This invention relates to a prodrug of the monophosphate nucleotide of the well-known oncology drug gemcitabine. Specifically, it relates to gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate when present as a single phosphate diastereoisomer and, in particular, it relates to the (S)-phosphate diastereoisomer which offers a remarkable and unexpected increase in solubility relative to the (R)-diastereoisomer. The (S)-phosphate epimer is also preferentially taken up into cyclodextrin solutions over the (R)-diastereoisomer.

Item Type: Patent
Date Type: Completion
Status: Published
Schools: Pharmacy
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Last Modified: 27 Sep 2021 10:56

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