Gemcitabine Prodrugs

NuCana PLC 2015. Gemcitabine Prodrugs. WO 2015/198058; GB51857. [Patent].

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Abstract

This invention relates to a prodrug of the monophosphate nucleotide of the well-known oncology drug gemcitabine. Specifically, it relates to gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate when present as a single phosphate diastereoisomer and, in particular, it relates to the (S)-phosphate diastereoisomer which offers a remarkable and unexpected increase in solubility relative to the (R)-diastereoisomer. The (S)-phosphate epimer is also preferentially taken up into cyclodextrin solutions over the (R)-diastereoisomer.

Item Type:	Patent
Date Type:	Completion
Status:	Published
Schools:	Pharmacy
Related URLs:	https://uspto.report/patent/grant/10,662...
Last Modified:	29 Nov 2022 09:43
URI:	https://orca.cardiff.ac.uk/id/eprint/144402

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