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Incidence of diabetic retinopathy in newly diagnosed subjects with type 2 diabetes mellitus over 5 years: Contribution of B-cell function

Roy Chowdhury, Sharmistha, Thomas, Rebecca L., Dunseath, Gareth J., Luzio, Stephen D., Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Owens, David R. 2022. Incidence of diabetic retinopathy in newly diagnosed subjects with type 2 diabetes mellitus over 5 years: Contribution of B-cell function. Journal of Diabetes and its Complications 36 (1) , 108028. 10.1016/j.jdiacomp.2021.108028

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Abstract

Aims Identifying and modulating risk factors is essential to prevent visual impairment due to diabetic retinopathy (DR). This study examines incident DR with metabolic and hormonal factors in newly-diagnosed, treatment naïve, individuals with Type2 Diabetes Mellitus (T2DM), over a 5 year period from diagnosis. Methods 233 T2DM subjects underwent serial DR screening using digital photography and standardised Meal Tolerance Tests at diagnosis and after 1, 2 and 5 years. Subjects (179) with no DR throughout the 5-year study period were compared with those who developed DR (54). Results Of 233 subjects, 54(23.2%) developed DR by 5 years, background DR in 50(93%) and exudative maculopathy in 4(7%) individuals. Of these subjects, 12(22%) developed DR after 1 year, 15(28%) after 2 years and 27(50%) after 5 years. At baseline, those with DR at 5 years had higher HbA1c (p = 0.017), higher fasting plasma glucose (PG) (p = 0.031) and postprandial PG (p = 0.009). They were associated with reduced basal β-cell secretory function (M0) (p = 0.025), lower (p = 0.000) postprandial β-cell responsiveness (M1) and β-cell function (HOMA-B) (p = 0.044). Conclusions There is an independent association between glycaemic control and β-cell dysfunction at the time of diagnosis of T2DM, with incident DR over a follow-up period of 5 years.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 1056-8727
Date of First Compliant Deposit: 7 October 2021
Date of Acceptance: 17 August 2021
Last Modified: 19 May 2023 04:11
URI: https://orca.cardiff.ac.uk/id/eprint/144718

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