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Is IL-6 a key cytokine target for therapy in COVID-19?

Jones, Simon A. and Hunter, Christopher A. 2021. Is IL-6 a key cytokine target for therapy in COVID-19? Nature Reviews Immunology 21 (6) , 337–339. 10.1038/s41577-021-00553-8

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Abstract

The identification of elevated IL-6 levels in patients with severe COVID-19 led to the rapid development of clinical trials targeting this cytokine. Overall, these trials do not support the widespread use of IL-6 antagonists in hospitalized patients with mild-to-moderate disease, but IL-6 antagonists may be beneficial when rapidly deployed in patients with severe COVID-19, as we discuss here.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Nature Research
ISSN: 1474-1733
Date of First Compliant Deposit: 7 October 2021
Date of Acceptance: 4 April 2021
Last Modified: 13 Oct 2021 11:15
URI: http://orca.cardiff.ac.uk/id/eprint/144740

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