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Templating effects in aristolochene synthase catalysis: elimination versus cyclisation

Faraldos, Juan A., Gonzalez, Veronica, Senske, Michael and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2011. Templating effects in aristolochene synthase catalysis: elimination versus cyclisation. Organic & Biomolecular Chemistry 9 (20) , pp. 6920-6923. 10.1039/c1ob06184d

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Abstract

Analysis of the products generated by mutants of aristolochene synthase from P. roqueforti (PR-AS) revealed the prominent structural role played by the aliphatic residue Leu 108 in maintaining the productive conformation of farnesyl diphosphate to ensure C1–C10 (σ-bond) ring-closure and hence (+)-aristolochene production.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Cardiff Catalysis Institute (CCI)
Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Royal Society of Chemistry
ISSN: 1477-0520
Funders: BBSRC, EPSRC
Last Modified: 18 Oct 2022 13:35
URI: https://orca.cardiff.ac.uk/id/eprint/14508

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