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Regulatory B cells: role in type 1 diabetes

Boldison, Joanne and Wong, F. Susan 2021. Regulatory B cells: role in type 1 diabetes. Frontiers in Immunology 12 , 746187. 10.3389/fimmu.2021.746187

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Abstract

Regulatory B cells (Bregs) have an anti-inflammatory role and can suppress autoimmunity, by employing both cytokine secretion and cell-contact mediated mechanisms. Numerous Breg subsets have been described and have overlapping phenotypes in terms of their immune expression markers or cytokine production. A hallmark feature of Bregs is the secretion of IL-10, although IL-35 and TGFβ−producing B cells have also been identified. To date, few reports have identified an impaired frequency or function of Bregs in individuals with type 1 diabetes; thus our understanding of the role played by these Breg subsets in the pathogenesis of this condition is limited. In this review we will focus on how regulatory B cells are altered in the development of type 1 diabetes, highlighting both frequency and function and discuss both human and animal studies.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Publisher: Frontiers Media
ISSN: 1664-3224
Date of First Compliant Deposit: 18 November 2021
Date of Acceptance: 2 September 2021
Last Modified: 23 Nov 2021 15:21
URI: http://orca.cardiff.ac.uk/id/eprint/145598

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