Ligneul, C., Palombo, M. ![]() ![]() |
![]() |
PDF
- Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (1MB) |
Abstract
Purpose:To assess the potential correlation between metabo-lites diffusion and relaxation in the mouse brain, which is ofimportance for interpreting and modeling metabolite diffusionbased on pure geometry, irrespective of relaxation properties(multicompartmental relaxation or surface relaxivity).Methods:A new diffusion-weighted magnetic resonance spec-troscopy sequence is introduced, dubbed “STE-LASER,” whichpresents several nice properties, in particular the absence ofcross-terms with selection gradients and a very clean localiza-tion. Metabolite diffusion is then measured in a large voxel in themouse brain at 11.7 Tesla using a cryoprobe, resulting in excel-lent signal-to-noise ratio, up to very highb-values under differentecho time, mixing time, and diffusion time combinations.Results:Our results suggest that the correlation betweenrelaxation and diffusion properties is extremely small or evennonexistent for metabolites in the mouse brain.Conclusion:The present work strongly supports the interpre-tation and modeling of metabolite diffusion primarily based ongeometry, irrespective of relaxation properties, at least undercurrent experimental conditions.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Psychology |
Additional Information: | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
Publisher: | Wiley |
ISSN: | 0740-3194 |
Date of First Compliant Deposit: | 18 March 2022 |
Date of Acceptance: | 23 February 2016 |
Last Modified: | 03 May 2023 22:48 |
URI: | https://orca.cardiff.ac.uk/id/eprint/147912 |
Citation Data
Cited 22 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
![]() |
Edit Item |