Metabolite diffusion up to very high b in the mouse brain In Vivo: Revisiting the potential correlation between relaxation and diffusion properties

Ligneul, C., Palombo, M. ORCID: https://orcid.org/0000-0003-4892-7967 and Valette, J. 2017. Metabolite diffusion up to very high b in the mouse brain In Vivo: Revisiting the potential correlation between relaxation and diffusion properties. Magnetic Resonance in Medicine 77 (4) , pp. 1390-1398. 10.1002/mrm.26217

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Abstract

Purpose:To assess the potential correlation between metabo-lites diffusion and relaxation in the mouse brain, which is ofimportance for interpreting and modeling metabolite diffusionbased on pure geometry, irrespective of relaxation properties(multicompartmental relaxation or surface relaxivity).Methods:A new diffusion-weighted magnetic resonance spec-troscopy sequence is introduced, dubbed “STE-LASER,” whichpresents several nice properties, in particular the absence ofcross-terms with selection gradients and a very clean localiza-tion. Metabolite diffusion is then measured in a large voxel in themouse brain at 11.7 Tesla using a cryoprobe, resulting in excel-lent signal-to-noise ratio, up to very highb-values under differentecho time, mixing time, and diffusion time combinations.Results:Our results suggest that the correlation betweenrelaxation and diffusion properties is extremely small or evennonexistent for metabolites in the mouse brain.Conclusion:The present work strongly supports the interpre-tation and modeling of metabolite diffusion primarily based ongeometry, irrespective of relaxation properties, at least undercurrent experimental conditions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Psychology
Additional Information:	This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Publisher:	Wiley
ISSN:	0740-3194
Date of First Compliant Deposit:	18 March 2022
Date of Acceptance:	23 February 2016
Last Modified:	03 May 2023 22:48
URI:	https://orca.cardiff.ac.uk/id/eprint/147912

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