The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia

Toh, Cheng-Hock, Wang, Guozheng and Parker, Alan L ORCID: https://orcid.org/0000-0002-9302-1761 2022. The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia. Clinical Medicine 22 (2) , pp. 140-144. 10.7861/clinmed.2022-0006

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Abstract

In the new science emanating from the COVID-19 pandemic, effective vaccine development has made a huge difference and saved countless lives. Vaccine roll-out led to the identification of rare cases of severe thrombotic and thrombocytopenic problems in some recipients. This apparent coupling of thrombosis with haemorrhagic potentiation might seem baffling but the ensuing clinical investigation rapidly shed important light on its molecular mechanism. This review outlines the current understanding on the role of adenovirus-based platforms, the immunogenic triggers and the immunothrombotic response underlying vaccine-induced immune thrombotic thrombocytopenia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
ISSN:	1470-2118
Funders:	NIHR
Date of First Compliant Deposit:	10 March 2022
Date of Acceptance:	20 January 2022
Last Modified:	16 Nov 2024 09:30
URI:	https://orca.cardiff.ac.uk/id/eprint/148303

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