Steps Toward Minimal Reporting Standards for Lipidomics Mass Spectrometry in Biomedical Research Publications

O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460, FitzGerald, Garret A., Murphy, Robert C., Liebisch, Gerhard, Dennis, Edward A., Quehenberger, Oswald, Subramaniam, Shankar and Wakelam, Michael J.O. 2020. Steps Toward Minimal Reporting Standards for Lipidomics Mass Spectrometry in Biomedical Research Publications. Circulation: Genomic and Precision Medicine 13 (6) , e003019. 10.1161/CIRCGEN.120.003019

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Abstract

Lipids in blood and tissues can serve as markers of normal and pathophysiological function in humans and can even reflect functions in specific tissues and organs. Lipidomics describes the analysis of large numbers of lipids using mass spectrometry (MS). The proper implementation of these methods in a manner that ensures data quality requires care and rigorous manual checking. Issues of reproducibility and overall data quality in publications and guidelines for authors submitting research are well-developed for areas that include genetics/genomics, proteomics, and clinical trials. For example, the Human Proteome Organization has developed minimum information publication guidelines for proteomics (https://www.hupo.org/HUPO-Minimum-Information-Publication-Guidelines). However, apart from specialized lipid publications, such as the Journal of Lipid Research, which adopted the Lipid Metabolites and Pathways Strategy Consortium (LIPID MAPS) classification, nomenclature, and structural drawing formats in their guidelines,1,2 there are few reporting guidelines in use for lipidomics data. This issue is particularly relevant to studies that are not focused on underpinning methodological approaches but instead cover broader issues of human health and disease. In many such articles, multiple analytical methods are applied, making it difficult to engage sufficient technical expertise to afford rigorous and comprehensive review. We developed a short set of guidelines for lipidomics submissions that we hope will contribute to improving reproducibility and standards in published work (Table). This is a living document, expected to be expanded as the field evolves. It is not intended to serve as a definitive final set of guidelines. To support this sort of activity, the Lipidomics Standard Initiative was recently established to create guidelines for major lipidomic workflows.3

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Publisher:	American Heart Association
ISSN:	2574-8300
Date of First Compliant Deposit:	5 January 2023
Last Modified:	08 May 2023 01:36
URI:	https://orca.cardiff.ac.uk/id/eprint/150561

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