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Cumulant expansion with localization: a new representation of the diffusion MRI signal

Afzali, Maryam, Pieciak, Tomasz, Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049, Schneider, Jurgen E. and Ozarslan, Evren 2022. Cumulant expansion with localization: a new representation of the diffusion MRI signal. Frontiers in Neuroimaging 1 , 958680. 10.3389/fnimg.2022.958680

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Abstract

Diffusion MR is sensitive to the microstructural features of a sample. Fine-scale characteristics can be probed by employing strong diffusion gradients while the low b-value regime is determined by the cumulants of the distribution of particle displacements. A signal representation based on the cumulants, however, suffers from a finite convergence radius and cannot represent the ‘localization regime' characterized by a stretched exponential decay that emerges at large gradient strengths. Here, we propose a new representation for the diffusion MR signal. Our method provides not only a robust estimate of the first three cumulants but also a meaningful extrapolation of the entire signal decay.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Psychology
Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher: Frontiers Media
Date of First Compliant Deposit: 9 August 2022
Date of Acceptance: 19 July 2022
Last Modified: 11 May 2023 05:22
URI: https://orca.cardiff.ac.uk/id/eprint/151821

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