Reduced brain oxygen metabolism in patients with multiple sclerosis: Evidence from dual-calibrated functional MRI

Chandler, Hannah L., Stickland, Rachael C. ORCID: https://orcid.org/0000-0003-3398-4272, Patitucci, Eleonora, Germuska, Michael ORCID: https://orcid.org/0000-0003-0580-4350, Chiarelli, Antonio M., Foster, Catherine, Bhome-Dhaliwal, Shona, Lancaster, Thomas M. ORCID: https://orcid.org/0000-0003-1322-2449, Saxena, Neeraj ORCID: https://orcid.org/0000-0003-0913-9351, Khot, Sharmila ORCID: https://orcid.org/0000-0003-4677-5680, Tomassini, Valentina ORCID: https://orcid.org/0000-0002-7368-6280 and Wise, Richard G. ORCID: https://orcid.org/0000-0003-1700-2144 2023. Reduced brain oxygen metabolism in patients with multiple sclerosis: Evidence from dual-calibrated functional MRI. Journal of Cerebral Blood Flow and Metabolism 43 (1) , pp. 115-128. 10.1177/0271678X221121849

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Abstract

Cerebral energy deficiency is increasingly recognised as an important feature of multiple sclerosis (MS). Until now, we have lacked non-invasive imaging methods to quantify energy utilisation and mitochondrial function in the human brain. Here, we used novel dual-calibrated functional magnetic resonance imaging (dc-fMRI) to map grey-matter (GM) deoxy-haemoglobin sensitive cerebral blood volume (CBVdHb), cerebral blood flow (CBF), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen consumption (CMRO2) in patients with MS (PwMS) and age/sex matched controls. By integrating a flow-diffusion model of oxygen transport, we evaluated the effective oxygen diffusivity of the capillary network (DC) and the partial pressure of oxygen at the mitochondria (PmO2). Significant between-group differences were observed as decreased CBF (p = 0.010), CMRO2 (p < 0.001) and DC (p = 0.002), and increased PmO2 (p = 0.043) in patients compared to controls. No significant differences were observed for CBVdHb (p = 0.389), OEF (p = 0.358), or GM volume (p = 0.302). Regional analysis showed widespread reductions in CMRO2 and DC for PwMS. Our findings may be indicative of reduced oxygen demand or utilisation in the MS brain and mitochondrial dysfunction. Our results suggest changes in brain physiology may precede MRI-detectable GM loss and may contribute to disease progression and neurodegeneration.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	SAGE Publications
ISSN:	0271-678X
Date of First Compliant Deposit:	27 September 2022
Date of Acceptance:	27 July 2022
Last Modified:	18 Jan 2024 13:57
URI:	https://orca.cardiff.ac.uk/id/eprint/152880

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