Driver, Ian D. ORCID: https://orcid.org/0000-0001-6815-0134, Maria Chiarelli, Antonio Maria, Chandler, Hannah L., Thomas, Hannah, Manolova, Svetla, Lu, Hanzhang, Wise, Richard G. and Germuska, Michael ORCID: https://orcid.org/0000-0003-0580-4350 2024. Breath-hold calibrated fMRI mapping of absolute cerebral metabolic rate of oxygen metabolism (CMRO2): an assessment of the accuracy and repeatability in a healthy adult population. Imaging Neuroscience 10.1162/imag_a_00298 |
Wright, Melissa E. ORCID: https://orcid.org/0000-0002-2744-4504, Crofts, Andrew, Davies, Saajan, Chandler, Hannah, Driver, Ian ORCID: https://orcid.org/0000-0001-6815-0134, Germuska, Michael ORCID: https://orcid.org/0000-0003-0580-4350, Giarratano, Ylenia, Bernabeu, Miguel O., Terry, Louise, Steventon, Jessica J. and Murphy, Kevin ORCID: https://orcid.org/0000-0002-6516-313X 2024. OP-07 Retinal and cortical vascular function across the menstrual cycle. Presented at: Women in Vision UK Winter Meeting 2023, Cambridge, UK, 12 December 2023. BMJ Open Ophthalmology. , vol.9 10.1136/bmjoo-2024-WVUK.7 |
Biondetti, Emma, Chiarelli, Antonio Maria, Germuska, Michael ORCID: https://orcid.org/0000-0003-0580-4350, Lipp, Ilona, Villani, Alessandro, Caporale, Alessandra S., Patitucci, Eleonora, Murphy, Kevin ORCID: https://orcid.org/0000-0002-6516-313X, Tomassini, Valentina ORCID: https://orcid.org/0000-0002-7368-6280 and Wise, Richard G. ORCID: https://orcid.org/0000-0003-1700-2144 2024. Breath-hold BOLD fMRI without CO2 sampling enables estimation of venous cerebral blood volume: potential use in normalization of stimulus-evoked BOLD fMRI data. NeuroImage 285 , 120492. 10.1016/j.neuroimage.2023.120492 |
Chandler, Hannah L., Stickland, Rachael C. ORCID: https://orcid.org/0000-0003-3398-4272, Patitucci, Eleonora, Germuska, Michael ORCID: https://orcid.org/0000-0003-0580-4350, Chiarelli, Antonio M., Foster, Catherine, Bhome-Dhaliwal, Shona, Lancaster, Thomas M. ORCID: https://orcid.org/0000-0003-1322-2449, Saxena, Neeraj ORCID: https://orcid.org/0000-0003-0913-9351, Khot, Sharmila ORCID: https://orcid.org/0000-0003-4677-5680, Tomassini, Valentina ORCID: https://orcid.org/0000-0002-7368-6280 and Wise, Richard G. ORCID: https://orcid.org/0000-0003-1700-2144 2023. Reduced brain oxygen metabolism in patients with multiple sclerosis: Evidence from dual-calibrated functional MRI. Journal of Cerebral Blood Flow and Metabolism 43 (1) , pp. 115-128. 10.1177/0271678X221121849 |
Chiarelli, A. M., Germuska, M. ORCID: https://orcid.org/0000-0003-0580-4350, Chandler, H. L., Stickland, R. C., Patitucci, E., Biondetti, E., Mascali, D., Saxena, N. ORCID: https://orcid.org/0000-0003-0913-9351, Khot, S. ORCID: https://orcid.org/0000-0003-4677-5680, Steventon, J., Foster, C. ORCID: https://orcid.org/0000-0003-1609-9458, Rodríguez-Soto, A. E., Englund, E., Murphy, K ORCID: https://orcid.org/0000-0002-6516-313X, Tomassini, V. ORCID: https://orcid.org/0000-0002-7368-6280, Wehrli, F. W. and Wise, R. G. ORCID: https://orcid.org/0000-0003-1700-2144 2022. A flow-diffusion model of oxygen transport for quantitative mapping of cerebral metabolic rate of oxygen (CMRO2) with single gas calibrated fMRI. Journal of Cerebral Blood Flow and Metabolism 42 (7) , pp. 1192-1209. 10.1177/0271678X221077332 |
Steventon, J.J., Chandler, H.L., Foster, C. ORCID: https://orcid.org/0000-0003-1609-9458, Dingsdale, H. ORCID: https://orcid.org/0000-0002-2919-8722, Germuska, M. ORCID: https://orcid.org/0000-0003-0580-4350, Massey, T. ORCID: https://orcid.org/0000-0002-9804-2131, Parker, G., Wise, R.G. ORCID: https://orcid.org/0000-0003-1700-2144 and Murphy, K. 2021. Changes in white matter microstructure and MRI-derived cerebral blood flow after one-week of exercise training. Scientific Reports 11 , 22061. 10.1038/s41598-021-01630-7 |
Chandler, Hannah L., Stickland, Rachael C. ORCID: https://orcid.org/0000-0003-3398-4272, Germuska, Michael ORCID: https://orcid.org/0000-0003-0580-4350, Patitucci, Eleonora, Foster, Catherine, Bhome-Dhaliwal, Shona, Lancaster, Thomas M., Saxena, Neeraj ORCID: https://orcid.org/0000-0003-0913-9351, Khot, Sharmila ORCID: https://orcid.org/0000-0003-4677-5680, Tomassini, Valentina ORCID: https://orcid.org/0000-0002-7368-6280 and Wise, Richard G. ORCID: https://orcid.org/0000-0003-1700-2144 2021. Using dual-calibrated functional MRI to map brain oxygen supply and consumption in multiple sclerosis. [Online]. bioRxiv. Available at: https://doi.org/10.1101/2021.01.07.425819 |
Champagne, Allen A, Coverdale, Nicole S, Germuska, Mike ORCID: https://orcid.org/0000-0003-0580-4350, Bhogal, Alex A and Cook, Douglas J 2020. Changes in volumetric and metabolic parameters relate to differences in exposure to sub-concussive head impacts. Journal of Cerebral Blood Flow and Metabolism 40 (7) , pp. 1453-1467. 10.1177/0271678X19862861 |
Merola, Alberto, Germuska, Michael A. ORCID: https://orcid.org/0000-0003-0580-4350, Warnert, Esther A. H., Richmond, Lewys, Helme, Daniel, Khot, Sharmila ORCID: https://orcid.org/0000-0003-4677-5680, Murphy, Kevin ORCID: https://orcid.org/0000-0002-6516-313X, Rogers, Peter J., Hall, Judith E. ORCID: https://orcid.org/0000-0002-6770-7372 and Wise, Richard G. ORCID: https://orcid.org/0000-0003-1700-2144 2017. Mapping the pharmacological modulation of brain oxygen metabolism: the effects of caffeine on absolute CMRO2 measured using dual calibrated fMRI. NeuroImage 155 , pp. 331-343. 10.1016/j.neuroimage.2017.03.028 |
Winfield, Jessica M., Tunariu, Nina, Rata, Mihaela, Miyazaki, Keiko, Jerome, Neil P., Germuska, Michael ORCID: https://orcid.org/0000-0003-0580-4350, Blackledge, Matthew D., Collins, David J., de Bono, Johann S., Yap, Timothy A., deSouza, Nandita M., Doran, Simon J., Koh, Dow-Mu, Leach, Martin O., Messiou, Christina and Orton, Matthew R. 2017. Extracranial soft-tissue Tumors: repeatability of apparent diffusion coefficient estimates from diffusion-weighted MR imaging. Radiology 284 (1) , p. 88. 10.1148/radiol.2017161965 |
Merola, Alberto, Murphy, Kevin ORCID: https://orcid.org/0000-0002-6516-313X, Stone, Alan J., Germuska, Michael A. ORCID: https://orcid.org/0000-0003-0580-4350, Griffeth, Valerie E. M., Blockley, Nicholas P., Buxton, Richard B. and Wise, Richard Geoffrey ORCID: https://orcid.org/0000-0003-1700-2144 2016. Measurement of oxygen extraction fraction (OEF): An optimized BOLD signal model for use with hypercapnic and hyperoxic calibration. NeuroImage 129 , pp. 159-174. 10.1016/j.neuroimage.2016.01.021 |
Suri, San, Mackay, Clare E., Kelly, Michael E., Germuska, Michael ORCID: https://orcid.org/0000-0003-0580-4350, Tunbridge, Elizabeth M., Frisoni, Giovanni B., Matthews, Paul M., Ebmeier, Klaus P., Bulte, Daniel P. and Filippini, Nicola 2015. Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele. Alzheimer's and Dementia 11 (6) , pp. 648-657. 10.1016/j.jalz.2014.05.1755 |
Germuska, Michael A. ORCID: https://orcid.org/0000-0003-0580-4350 and Bulte, Daniel P. 2014. MRI measurement of oxygen extraction fraction, mean vessel size and cerebral blood volume using serial hyperoxia and hypercapnia. NeuroImage 92 , pp. 132-142. 10.1016/j.neuroimage.2014.02.002 |
Germuska, Michael A. ORCID: https://orcid.org/0000-0003-0580-4350, Meakin, James A. and Bulte, Daniel P. 2013. The influence of noise on BOLD-mediated vessel size imaging analysis methods. Journal of Cerebral Blood Flow and Metabolism 33 (12) , pp. 1857-1863. 10.1038/jcbfm.2013.141 |
Hare, Hannah V., Germuska, Michael A. ORCID: https://orcid.org/0000-0003-0580-4350, Kelly, Michael E. and Bulte, Daniel P. 2013. Comparison of CO2 in air versus carbogen for the measurement of cerebrovascular reactivity with magnetic resonance imaging. Journal of Cerebral Blood Flow and Metabolism 33 (11) , pp. 1799-1805. 10.1038/jcbfm.2013.131 |
Blockley, Nicholas P., Griffeth, Valerie E. M., Germuska, Michael A. ORCID: https://orcid.org/0000-0003-0580-4350, Bulte, Daniel P. and Buxton, Richard B. 2013. An analysis of the use of hyperoxia for measuring venous cerebral blood volume: Comparison of the existing method with a new analysis approach. NeuroImage 72 , pp. 33-40. 10.1016/j.neuroimage.2013.01.039 |
Germuska, Michael A. ORCID: https://orcid.org/0000-0003-0580-4350, Tunariu, N., Leach, M. O., Xu, Jian and Payne, G. S. 2012. An evaluation of motion compensation strategies and repeatability for abdominal 1H MR spectroscopy measurements in volunteer studies and clinical trials. Nmr in Biomedicine 25 (6) , pp. 859-865. 10.1002/nbm.1802 |
Bulte, D. P., Kelly, M., Germuska, Michael A. ORCID: https://orcid.org/0000-0003-0580-4350, Xie, J., Chappell, M. A., Okell, T. W., Bright, Molly G. ORCID: https://orcid.org/0000-0001-7257-9646 and Jezzard, P. 2012. Quantitative measurement of cerebral physiology using respiratory-calibrated MRI. NeuroImage 60 (1) , pp. 582-591. 10.1016/j.neuroimage.2011.12.017 |
Yap, Timothy A., Olmos, David, Brunetto, Andre T., Tunariu, Nina, Barriuso, Jorge, Riisnaes, Ruth, Pope, Lorna, Clark, Jeremy, Futreal, Andrew, Germuska, Michael ORCID: https://orcid.org/0000-0003-0580-4350, Collins, David, deSouza, Nandita M., Leach, Martin O., Savage, Ronald E., Waghorne, Carol, Chai, Feng, Garmey, Edward, Schwartz, Brian, Kaye, Stan B. and de Bono, Johann S. 2011. Phase I trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies. Journal of Clinical Oncology 29 (10) , pp. 1271-1279. 10.1200/JCO.2010.31.0367 |
Riches, Sophie F., Payne, Geoffrey S., Morgan, Veronica A., Sandhu, Samir, Fisher, Cyril, Germuska, Michael ORCID: https://orcid.org/0000-0003-0580-4350, Collins, David J., Thompson, Alan and deSouza, Nandita M. 2009. MRI in the detection of prostate cancer: combined apparent diffusion coefficient, metabolite ratio, and vascular parameters. American Journal of Roentgenology 193 (6) , pp. 1583-1591. |
Yap, T. A., Lolkema, M. P., Tunariu, N., Tan, D. S. W., Brunetto, A. T., Germuska, Michael ORCID: https://orcid.org/0000-0003-0580-4350, Garmey, E., Li, J., deSouza, N. and de Bono, J. S. 2009. Pharmacokinetic and pharmacodynamic Phase I trial of ARQ 197 incorporating dynamic contrast-enhanced (DCE) and diffusion weighted (DW) magnetic resonance imaging (MRI) studies investigating the antiangiogenic and antitumor activity of selective c-Met inhibition. EJC Supplements 7 (2) , p. 121. |
Yap, T. A., Frentzas, S., Tunariu, N., Barriuso, J., Harris, D., Germuska, Michael ORCID: https://orcid.org/0000-0003-0580-4350, Waghorne, C., Li, J., deSouza, N. and de Bono, J. S. 2009. Final results of a pharmacokinetic (PK) and pharmacodynamic (PD) phase I trial of ARQ 197 incorporating dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) studies investigating the antiangiogenic activity of selective c-Met inhibition. Journal of Clinical Oncology 27 (15) , abstr 3523. |
Spratlin, J., Arkenau, H. T., George, S., Serkova, N. J., Germuska, Michael ORCID: https://orcid.org/0000-0003-0580-4350, Brock, K., Gedrich, R., Scurr, M., Demetri, G. D. and Camidge, D. R. 2008. Analyses of pharmacodynamic (PD) assessments collected during expanded cohorts (EC) of a phase I trial with OSI-930, a multi-targeted oral tyrosine kinase inhibitor (TKI). EJC Supplements 6 (12) , p. 19. 10.1016/S1359-6349(08)71981-5 |
Germuska, Michael A. ORCID: https://orcid.org/0000-0003-0580-4350, Saha, S., Fiala, J. and Barbas, H. 2006. Synaptic distinction of laminar-specific prefrontal-temporal pathways in primates. Cerebral Cortex 16 (6) , pp. 865-875. 10.1093/cercor/bhj030 |