Human CD34+ hematopoietic stem cell hierarchy: how far are we with its delineation at the most primitive level?

Anjos-Afonso, Fernando ORCID: https://orcid.org/0000-0003-4392-488X and Bonnet, Dominique 2023. Human CD34+ hematopoietic stem cell hierarchy: how far are we with its delineation at the most primitive level? Blood 142 (6) , pp. 509-518. 10.1182/blood.2022018071

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Abstract

The ability to isolate and characterize different HSPC (hematopoietic stem/progenitor cell) populations opens avenues to understand how hematopoiesis is regulated during development, homeostasis and regeneration, as well as in age-related conditions such as clonal hematopoiesis and leukemogenesis. Significant progress has been made in the past few decades in determining the composition of the cell types that exist in this system, but the most significant advances have come from mouse studies. However, recent breakthroughs have made significant strides that have enhanced the resolution of the human primitive hematopoietic compartment. Therefore, we aim to review this subject not only from a historical perspective but also to discuss the progress made in the characterization of the human post-natal CD34+ HSC-enriched populations. This approach will enable us to shed light on the potential future translational applicability of human HSCs.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by-nc-nd/4.0/, Start Date: 2023-04-06
Publisher:	American Society of Hematology
ISSN:	0006-4971
Date of First Compliant Deposit:	15 November 2023
Date of Acceptance:	19 March 2023
Last Modified:	15 Nov 2023 14:43
URI:	https://orca.cardiff.ac.uk/id/eprint/158526

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