CD1 displays its own negative regulators

Shahine, Adam, Van Rhijn, Ildiko, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522 and Moody, D. Branch 2023. CD1 displays its own negative regulators. Current Opinion in Immunology 83 , 102339. 10.1016/j.coi.2023.102339

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Abstract

After two decades of the study of lipid antigens that activate CD1-restricted T cells, new studies show how autoreactive αβ T-cell receptors (TCRs) can directly recognize the outer surface of CD1 proteins in ways that are lipid-agnostic. Most recently, this lipid agnosticism has turned to negativity, with the discovery of natural CD1 ligands that dominantly negatively block autoreactive αβ TCR binding to CD1a and CD1d. This review highlights the basic differences between positive and negative regulation of cellular systems. We outline strategies to discover lipid inhibitors of CD1-reactive T cells, whose roles in vivo are becoming clear, especially in CD1-mediated skin disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISSN:	0952-7915
Date of First Compliant Deposit:	5 October 2023
Date of Acceptance:	21 August 2023
Last Modified:	06 Oct 2023 15:00
URI:	https://orca.cardiff.ac.uk/id/eprint/162973

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