Indole-based compounds as potential drug candidates for SARS-CoV-2

Girgis, Adel S., Panda, Siva S., Kariuki, Benson M. ORCID: https://orcid.org/0000-0002-8658-3897, Bekheit, Mohamed S., Barghash, Reham F. and Aboshouk, Dalia R. 2023. Indole-based compounds as potential drug candidates for SARS-CoV-2. Molecules 28 (18) , 6603. 10.3390/molecules28186603

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Abstract

The COVID-19 pandemic has posed a significant threat to society in recent times, endangering human health, life, and economic well-being. The disease quickly spreads due to the highly infectious SARS-CoV-2 virus, which has undergone numerous mutations. Despite intense research efforts by the scientific community since its emergence in 2019, no effective therapeutics have been discovered yet. While some repurposed drugs have been used to control the global outbreak and save lives, none have proven universally effective, particularly for severely infected patients. Although the spread of the disease is generally under control, anti-SARS-CoV-2 agents are still needed to combat current and future infections. This study reviews some of the most promising repurposed drugs containing indolyl heterocycle, which is an essential scaffold of many alkaloids with diverse bio-properties in various biological fields. The study also discusses natural and synthetic indole-containing compounds with anti-SARS-CoV-2 properties and computer-aided drug design (in silico studies) for optimizing anti-SARS-CoV-2 hits/leads.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	MDPI
ISSN:	1420-3049
Date of First Compliant Deposit:	10 October 2023
Date of Acceptance:	9 September 2023
Last Modified:	19 Oct 2023 14:21
URI:	https://orca.cardiff.ac.uk/id/eprint/163109

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