Targeting metastasis and cancer stem-like cells in triple negative breast cancer through inhibition of focal adhesion kinase [Poster Abstract]

Jones, Samuel, Smith, Christopher, Hiscox, Stephen ORCID: https://orcid.org/0000-0003-0105-2702 and Jiang, Wen G. ORCID: https://orcid.org/0000-0002-3283-1111 2016. Targeting metastasis and cancer stem-like cells in triple negative breast cancer through inhibition of focal adhesion kinase [Poster Abstract]. Presented at: AACR 107th Annual Meeting 2016, New Orleans, LA, USA, 16-20 April 2016. Cancer Research. , vol.76 (S14) p. 4125. 10.1158/1538-7445.am2016-4125

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Abstract

Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer closely associated with an early pattern of metastasis and lack of targeted therapies. As such the prognosis for TNBC is poor. Whilst targeting signalling pathways known to promote metastasis-supporting behaviours may well provide an important therapeutic opportunity for such cancers, recent evidence points to an association between cancer stem-like cell (CSC) populations and the aggressive behaviours of TNBC, including their chemoresistance.

Item Type:	Conference or Workshop Item (Poster)
Date Type:	Publication
Status:	Published
Schools:	Medicine Pharmacy
Last Modified:	31 May 2024 21:19
URI:	https://orca.cardiff.ac.uk/id/eprint/163175

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