In vivo myelin water quantification using diffusion–relaxation correlation MRI: A comparison of 1D and 2D methods

Endt, Sebastian, Engel, Maria, Naldi, Emanuele, Assereto, Rodolfo, Molendowska, Malwina, Mueller, Lars, Mayrink Verdun, Claudio, Pirkl, Carolin M., Palombo, Marco ORCID: https://orcid.org/0000-0003-4892-7967, Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049 and Menzel, Marion I. 2023. In vivo myelin water quantification using diffusion–relaxation correlation MRI: A comparison of 1D and 2D methods. Applied Magnetic Resonance 54 , pp. 1571-1588. 10.1007/s00723-023-01584-1

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Abstract

Multidimensional Magnetic Resonance Imaging (MRI) is a versatile tool for microstructure mapping. We use a diffusion weighted inversion recovery spin echo (DW-IR-SE) sequence with spiral readouts at ultra-strong gradients to acquire a rich diffusion–relaxation data set with sensitivity to myelin water. We reconstruct 1D and 2D spectra with a two-step convex optimization approach and investigate a variety of multidimensional MRI methods, including 1D multi-component relaxometry, 1D multi-component diffusometry, 2D relaxation correlation imaging, and 2D diffusion-relaxation correlation spectroscopic imaging (DR-CSI), in terms of their potential to quantify tissue microstructure, including the myelin water fraction (MWF). We observe a distinct spectral peak that we attribute to myelin water in multi-component T1 relaxometry, T1-T2 correlation, T1-D correlation, and T2-D correlation imaging. Due to lower achievable echo times compared to diffusometry, MWF maps from relaxometry have higher quality. Whilst 1D multi-component T1 data allows much faster myelin mapping, 2D approaches could offer unique insights into tissue microstructure and especially myelin diffusion.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Publisher:	Springer
ISSN:	0937-9347
Date of First Compliant Deposit:	24 October 2023
Date of Acceptance:	25 July 2023
Last Modified:	04 Dec 2023 14:42
URI:	https://orca.cardiff.ac.uk/id/eprint/163454

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