Endt, Sebastian, Engel, Maria, Naldi, Emanuele, Assereto, Rodolfo, Molendowska, Malwina, Mueller, Lars, Mayrink Verdun, Claudio, Pirkl, Carolin M., Palombo, Marco  ORCID: https://orcid.org/0000-0003-4892-7967, Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049 and Menzel, Marion I.
2023.
In vivo myelin water quantification using diffusion–relaxation correlation MRI: A comparison of 1D and 2D methods.
Applied Magnetic Resonance
54
, pp. 1571-1588.
10.1007/s00723-023-01584-1
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Abstract
Multidimensional Magnetic Resonance Imaging (MRI) is a versatile tool for microstructure mapping. We use a diffusion weighted inversion recovery spin echo (DW-IR-SE) sequence with spiral readouts at ultra-strong gradients to acquire a rich diffusion–relaxation data set with sensitivity to myelin water. We reconstruct 1D and 2D spectra with a two-step convex optimization approach and investigate a variety of multidimensional MRI methods, including 1D multi-component relaxometry, 1D multi-component diffusometry, 2D relaxation correlation imaging, and 2D diffusion-relaxation correlation spectroscopic imaging (DR-CSI), in terms of their potential to quantify tissue microstructure, including the myelin water fraction (MWF). We observe a distinct spectral peak that we attribute to myelin water in multi-component T1 relaxometry, T1-T2 correlation, T1-D correlation, and T2-D correlation imaging. Due to lower achievable echo times compared to diffusometry, MWF maps from relaxometry have higher quality. Whilst 1D multi-component T1 data allows much faster myelin mapping, 2D approaches could offer unique insights into tissue microstructure and especially myelin diffusion.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Psychology |
| Publisher: | Springer |
| ISSN: | 0937-9347 |
| Date of First Compliant Deposit: | 24 October 2023 |
| Date of Acceptance: | 25 July 2023 |
| Last Modified: | 04 Dec 2023 14:42 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/163454 |
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