Nanoporous aluminosilicate mediated synthesis of 2- and 2,2-substituted 2,3-dihydroquinazolin-4(1H)-ones

Aldred, Matthew P., Li, Fuxuan, Kuang, Rong, Thomas, Owen L., Davies, Thomas E., Taylor, Stuart H. ORCID: https://orcid.org/0000-0002-1933-4874, Miedziak, Peter J. and Graham, Andrew E. 2024. Nanoporous aluminosilicate mediated synthesis of 2- and 2,2-substituted 2,3-dihydroquinazolin-4(1H)-ones. Tetrahedron Letters 140 , 155037. 10.1016/j.tetlet.2024.155037

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Abstract

Nanoporous silicate materials, made by an operationally simple evaporation-induced self-assembly (EISA) approach, efficiently catalyze the formation of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones from aldehydes and dimethyl acetals. This methodology can be extended to encompass the reaction of ketones and ketals to provide facile access to 2,2-disubstituted and spiro dihydroquinazolin-4(1H)-ones in high yields and short reaction times.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry Research Institutes & Centres > Cardiff Catalysis Institute (CCI)
Publisher:	Elsevier
ISSN:	0040-4039
Funders:	Leverhulme Trust
Date of First Compliant Deposit:	28 March 2024
Date of Acceptance:	25 March 2024
Last Modified:	26 Mar 2025 03:00
URI:	https://orca.cardiff.ac.uk/id/eprint/167602

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