Aldred, Matthew P., Li, Fuxuan, Kuang, Rong, Thomas, Owen L., Davies, Thomas E., Taylor, Stuart H.  ORCID: https://orcid.org/0000-0002-1933-4874, Miedziak, Peter J. and Graham, Andrew E.
2024.
Nanoporous aluminosilicate mediated synthesis of 2- and 2,2-substituted 2,3-dihydroquinazolin-4(1H)-ones.
Tetrahedron Letters
140
, 155037.
10.1016/j.tetlet.2024.155037
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Official URL: http://dx.doi.org/10.1016/j.tetlet.2024.155037
Abstract
Nanoporous silicate materials, made by an operationally simple evaporation-induced self-assembly (EISA) approach, efficiently catalyze the formation of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones from aldehydes and dimethyl acetals. This methodology can be extended to encompass the reaction of ketones and ketals to provide facile access to 2,2-disubstituted and spiro dihydroquinazolin-4(1H)-ones in high yields and short reaction times.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Chemistry Research Institutes & Centres > Cardiff Catalysis Institute (CCI) |
| Publisher: | Elsevier |
| ISSN: | 0040-4039 |
| Funders: | Leverhulme Trust |
| Date of First Compliant Deposit: | 28 March 2024 |
| Date of Acceptance: | 25 March 2024 |
| Last Modified: | 26 Mar 2025 03:00 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/167602 |
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