A structural perspective of how T cell receptors recognize the CD1 family of lipid antigen-presenting molecules

Cao, Thinh-Phat, Shahine, Adam, Cox, Liam R., Besra, Gurdyal S., Moody, D. Branch and Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522 2024. A structural perspective of how T cell receptors recognize the CD1 family of lipid antigen-presenting molecules. Journal of Biological Chemistry 300 (8) , 107511. 10.1016/j.jbc.2024.107511

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Abstract

The CD1 family of antigen-presenting molecules adopt a Major Histocompatibility Complex class I (MHC-I) fold. Whereas MHC molecules present peptides, the CD1 family has evolved to bind self- and foreign-lipids. The CD1 family of antigen-presenting molecules comprises four members, CD1a, CD1b, CD1c, CD1d, that differ in their architecture around the lipid-binding cleft, thereby enabling diverse lipids to be accommodated. These CD1-lipid complexes are recognised by T cell receptors (TCRs) expressed on T cells, either through dual recognition of CD1 and lipid or in a new model whereby the TCR directly contacts CD1, thereby triggering an immune response. Chemical syntheses of lipid antigens, and analogues thereof, have been crucial in understanding the underlying specificity of T cell-mediated lipid immunity. This review will focus on our current understanding of how TCRs interact with CD1-lipid complexes, highlighting how it can be fundamentally different from TCR-MHC-peptide co-recognition.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/, Start Date: 2024-06-26
Publisher:	Elsevier
ISSN:	0021-9258
Date of First Compliant Deposit:	2 July 2024
Date of Acceptance:	24 June 2024
Last Modified:	05 Aug 2024 14:05
URI:	https://orca.cardiff.ac.uk/id/eprint/170230

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