Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapy

Nicholson, Robert Ian, Staka, C., Boyns, Frances Elizabeth, Hutcheson, Iain Robert and Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015 2004. Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapy. Endocrine-Related Cancer 11 (4) , pp. 623-641. 10.1677/erc.1.00778

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Abstract

There is an increasing body of evidence demonstrating that elevated growth signaling in breast cancer cells can promote forms of endocrine resistance in either an estrogen receptor-dependent or -independent manner. The current article reviews what is known about such growth factor signaling networks and resistance to estrogen withdrawal and considers the many novel therapeutic opportunities that stem from this knowledge.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology
Publisher:	Society for Endocrinology
ISSN:	1351-0088
Last Modified:	18 Oct 2022 14:18
URI:	https://orca.cardiff.ac.uk/id/eprint/17105

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