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Number of items: 204.

Achinger-Kawecka, Joanna, Stirzaker, Clare, Portman, Neil, Campbell, Elyssa, Chia, Kee-Ming, Du, Qian, Laven-Law, Geraldine, Nair, Shalima S., Yong, Aliza, Wilkinson, Ashleigh, Clifton, Samuel, Milioli, Heloisa H., Alexandrou, Sarah, Caldon, C. Elizabeth, Song, Jenny, Khoury, Amanda, Meyer, Braydon, Chen, Wenhan, Pidsley, Ruth, Qu, Wenjia, Gee, Julia M. W.

, Schmitt, Anthony, Wong, Emily S., Hickey, Theresa E., Lim, Elgene and Clark, Susan J. 2024. The potential of epigenetic therapy to target the 3D epigenome in endocrine-resistant breast cancer. Nature Structural and Molecular Biology 31 , pp. 498-512. 10.1038/s41594-023-01181-7

Beresford, Mark, Casbard, Angela

, Hudson, Zoe, Carucci, Margherita, Ingarfield, Kate, Gee, Julia

, Smith, Joanna

, Kitson, Terri

, Alchami, Fouad, Madden, Tracie-Ann

, Hayward, Larrie, Hwang, David, Spensley, Saiqa, Waters, Simon, Wheatley, Duncan and Jones, Robert H.

2023. Fulvestrant plus vandetanib versus placebo for the treatment of patients with metastatic breast cancer resistant to aromatase inhibitor therapy (FURVA): a multicentre, Phase 2, randomised controlled trial. BJC Reports 1 (1) , 13. 10.1038/s44276-023-00016-8

Eissa, Ahmed G., Powell, Lauren E., Gee, Julia

, Foster, Paul A. and Simons, Claire

2023. Pyridine based dual binding site aromatase (CYP19A1) inhibitors. RSC Medicinal Chemistry 14 (2) , pp. 356-366. 10.1039/d2md00352j

Intabli, Haya, Gee, Julia M.

, Oesterreich, Steffi, Yeoman, Mark S., Allen, Marcus C., Qattan, Amal and Flint, Melanie S. 2023. Glucocorticoid induced loss of oestrogen receptor alpha gene methylation and restoration of sensitivity to fulvestrant in triple negative breast cancer. Gene 851 , 147022. 10.1016/j.gene.2022.147022

Eissa, Ahmed G., Barrow, Denise, Gee, Julia

, Powell, Lauren E., Foster, Paul A. and Simons, Claire

2022. 4th generation nonsteroidal aromatase inhibitors: An iterative SAR-guided design, synthesis, and biological evaluation towards picomolar dual binding inhibitors. European Journal of Medicinal Chemistry 240 , 114569. 10.1016/j.ejmech.2022.114569

Saunus, Jodi M., De Luca, Xavier M., Northwood, Korinne, Raghavendra, Ashwini, Hasson, Alexander, McCart Reed, Amy E., Lim, Malcolm, Lal, Samir, Vargas, A. Cristina, Kutasovic, Jamie R., Dalley, Andrew J., Miranda, Mariska, Kalaw, Emarene, Kalita-de Croft, Priyakshi, Gresshoff, Irma, Al-Ejeh, Fares, Gee, Julia M. W.

, Ormandy, Chris, Khanna, Kum Kum, Beesley, Jonathan, Chenevix-Trench, Georgia, Green, Andrew R., Rakha, Emad A., Ellis, Ian O., Nicolau, Dan V., Simpson, Peter T. and Lakhani, Sunil R. 2022. Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer. npj Breast Cancer 8 , 57. 10.1038/s41523-022-00425-x

Jones, Samuel, Farr, Georgia, Nimmanon, Thirayost, Ziliotto, Silvia, Gee, Julia M.W.

and Taylor, Kathryn M.

2022. The importance of targeting signalling mechanisms of the SLC39A family of zinc transporters to inhibit endocrine resistant breast cancer. Exploration of Targeted Anti-tumor Therapy 3 , pp. 224-239. 10.37349/etat.2022.00080

Campbell, Christine, Mathew, John, Ellis, Ian O., Bradbury, Ian, Borgquist, Signe, Elebro, Karin, Green, Andrew R., Finlay, Pauline, Gee, Julia M. W.

and Robertson, John F. R. 2020. Markers of steroid receptor, kinase signalling pathways and Ki-67 expression in relation to tamoxifen sensitivity and resistance. Translational Breast Cancer Research 1 , 29. 10.21037/tbcr-20-31

Nimmanon, Thirayost, Ziliotto, Silvia, Ogle, Olivia, Burt, Anna, Gee, Julia M. W.

, Andrews, Glen K., Kille, Pete

, Hogstrand, Christer, Maret, Wolfgang and Taylor, Kathryn M.

2020. The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis. Cellular and Molecular Life Sciences 78 , pp. 1781-1798. 10.1007/s00018-020-03616-6

Robertson, John F.R., Coleman, Robert E., Cheung, Kwok-Leung, Evans, Abigail, Holcombe, Chris, Skene, Anthony, Rea, Daniel, Ahmed, Samreen, Jahan, Ali, Horgan, Kieran, Rauchhaus, Petra, Littleford, Roberta, Cheung, S.Y. Amy, Cullberg, Marie, de Bruin, Elza C., Koulai, Loumpiana, Lindemann, Justin P. O., Pass, Martin, Rugman, Paul, Schiavon, Gaia, Deb, Rahul, Finlay, Pauline, Foxley, Andrew and Gee, Julia M.W.

2020. Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT). Clinical Cancer Research 26 (7) , pp. 1574-1585. 10.1158/1078-0432.CCR-19-3053

Achinger-Kawecka, Joanna, Valdes-Mora, Fatima, Luu, Phuc-Loi, Giles, Katherine A., Caldon, C. Elizabeth, Qu, Wenjia, Nair, Shalima, Soto, Sebastian, Locke, Warwick J., Yeo-Teh, Nicole S., Gould, Cathryn M., Du, Qian, Smith, Grady C., Ramos, Irene R., Fernandez, Kristine F., Hoon, Dave S., Gee, Julia M. W.

, Stirzaker, Clare and Clark, Susan J. 2020. Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer. Nature Communications 11 (1) , 320. 10.1038/s41467-019-14098-x

Ziliotto, Silvia, Gee, Julia M. W.

, Ellis, Ian O., Green, Andrew R., Finlay, Pauline, Gobbato, Anna and Taylor, Kathryn M.

2019. Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer. Metallomics 11 (9) , pp. 1579-1592. 10.1039/C9MT00136K

Santiago-Gómez, Angélica, Kedward, Thomas, Simões, Bruno M., Dragoni, Ilaria, NicAmhlaoibh, Roisin, Trivier, Elisabeth, Sabin, Verity, Gee, Julia M.

, Sims, Andrew H., Howell, Sacha J. and Clarke, Robert B. 2019. PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer. Cancer Letters 458 , pp. 66-75. 10.1016/j.canlet.2019.05.014

Milevskiy, Michael J. G., Gujral, Udai, Del Lama Marques, Carolina, Stone, Andrew, Northwood, Korinne, Burke, Lez J., Gee, Julia M. W.

, Nephew, Kenneth, Clark, Susan and Brown, Melissa A. 2019. MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER+ breast cancer. British Journal of Cancer 120 , pp. 621-632. 10.1038/s41416-019-0395-8

Piggott, Luke, Silva, Ana

, Robinson, Timothy, Santiago-Gomez, Angelica, Simoes, Bruno M., Becker, Michael, Fichtner, Iduna, Andera, Ladislav, Young, Philippa, Morris, Christine, Barret-Lee, Peter, Alchami, Fouad, Piva, Marco, Vivanco, Maria d. M., Clarke, Robert B., Gee, Julia

and Clarkson, Richard

2018. Acquired resistance of ER-positive breast cancer to endocrine treatment confers an adaptive sensitivity to TRAIL through post-translational downregulation of c-FLIP. Clinical Cancer Research 24 (10) , pp. 2452-2463. 10.1158/1078-0432.CCR-17-1381

Milevskiy, Michael J.G., Al-Ejeh, Fares, Saunus, Jodi M., Northwood, Korinne S., Bailey, Peter J., Betts, Joshua A., McCart Reed, Amy E., Nephew, Kenneth P., Stone, Andrew, Gee, Julia Margaret Wendy

, Dowhan, Dennis H., Dray, Eloise, Shewan, Annette M., French, Juliet D., Edwards, Stacey L., Clark, Susan J., Lakhani, Sunil R. and Brown, Melissa A. 2016. Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer. Human Molecular Genetics 25 (15) , pp. 3269-3283. 10.1093/hmg/ddw177

Bellerby, Rebecca, Smith, Chris, Kyme, Sue, Gee, Julia

, Günthert, Ursula, Green, Andy, Rakha, Emad, Barrett-Lee, Peter and Hiscox, Stephen

2016. Overexpression of specific CD44 isoforms is associated with aggressive cell features in acquired endocrine resistance. Frontiers in Oncology 6 , 145. 10.3389/fonc.2016.00145

Agrawal, Amit, Robertson, John F.R., Cheung, Kwok L., Gutteridge, Eleanor, Ellis, Ian O., Nicholson, Robert I. and Gee, Julia M.W.

2016. Biological effects of fulvestrant on estrogen receptor positive human breast cancer: short, medium and long-term effects based on sequential biopsies. International Journal of Cancer 138 (1) , pp. 146-159. 10.1002/ijc.29682

Abdulkareem, Zana Azeez, Gee, Julia Margaret Wendy

, Cox, Charles and Wann, Kenneth Taylor 2016. Knockdown of the small conductance Ca2+-activated K+ channels is potently cytotoxic in breast cancer cell lines. British Journal of Pharmacology 173 (1) , pp. 177-190. 10.1111/bph.13357

Gallego-Ortega, David, Ledger, Anita, Roden, Daniel L., Law, Andrew M. K., Magenau, Astrid, Kikhtyak, Zoya, Cho, Christina, Allerdice, Stephanie L., Lee, Heather J., Valdes-Mora, Fatima, Herrmann, David, Salomon, Robert, Young, Adelaide I. J., Lee, Brian Y., Sergio, C. Marcelo, Kaplan, Warren, Piggin, Catherine, Conway, James R. W., Rabinovich, Brian, Millar, Ewan K. A., Oakes, Samantha R., Chtanova, Tatyana, Swarbrick, Alexander, Naylor, Matthew J., O'Toole, Sandra, Green, Andrew R., Timpson, Paul, Gee, Julia M.W.

, Ellis, Ian O., Clark, Susan J. and Ormandy, Christopher J. 2015. ELF5 drives lung metastasis in luminal breast cancer through recruitment of Gr1+ CD11b+ myeloid-derived suppressor cells. PLoS Biology 13 (12) , e1002330. 10.1371/journal.pbio.1002330

Simões, Bruno M., O'Brien, Ciara S., Eyre, Rachel, Silva, Andreia, Yu, Ling, Sarmiento-Castro, Aida, Alférez, Denis G., Spence, Kath, Santiago-Gómez, Angélica, Chemi, Francesca, Acar, Ahmet, Gandhi, Ashu, Howell, Anthony, Brennan, Keith, Rydén, Lisa, Catalano, Stefania, Andó, Sebastiano, Gee, Julia Margaret Wendy

, Ucar, Ahmet, Sims, Andrew H., Marangoni, Elisabetta, Farnie, Gillian, Landberg, Göran, Howell, Sacha J. and Clarke, Robert B. 2015. Anti-estrogen resistance in human breast tumors is driven by JAG1-NOTCH4-dependent cancer stem cell activity. Cell Reports 12 (12) , pp. 1968-1977. 10.1016/j.celrep.2015.08.050

Stone, Andrew, Zotenko, Elena, Locke, Warwick J., Korbie, Darren, Millar, Ewan K. A., Pidsley, Ruth, Stirzaker, Clare, Graham, Peter, Trau, Matt, Musgrove, Elizabeth A., Nicholson, Robert I., Gee, Julia M. W.

and Clark, Susan J. 2015. DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer. Nature Communications 6 , 7758. 10.1038/ncomms8758

Gee, Julia M.

, Meng, Mei Yee, McClelland, Richard A., Mottram, Huw J., Kyme, Susan R., Finlay, Pauline, Goddard, Lindy, Dutkowski, Carol M., Barrow, Denise, Parson, Walther and Fiegl, Heidi 2015. A new cell panel to study oestrogen receptor loss in acquired endocrine resistant breast cancer. Cancer Research 75 (9) , P3-05-19.

Robertson, John F.R., Lindemann, Justin, Garnett, Sally, Anderson, Elizabeth, Nicholson, Robert I., Kuter, Irene and Gee, Julia Margaret Wendy

2014. A good drug made better: the Fulvestrant Dose Response Story. Clinical Breast Cancer 14 (6) , pp. 381-389. 10.1016/j.clbc.2014.06.005

Gee, Julia Margaret Wendy

, Goddard, Lindy, Mottram, Huw James, Burmi, Rajpal, Pumford, Sara L., Dutkowski, Carol M., Barrow, Denise, Hutcheson, Iain Robert, Nicholson, Robert Ian, Ellis, Ian O. and Elvin, Paul 2014. Increased Ret signalling and impact of vandetanib in acquired tamoxifen resistant breast cancer. Cancer Research 74 (19) , 738. 10.1158/1538-7445.AM2014-738

Britton, David, Zen, Yoh, Quaglia, Alberto, Selzer, Stefan, Mitra, Vikram, Lößner, Christopher, Jung, Stephan, Böhm, Gitte, Schmid, Peter, Prefot, Petra, Hoehle, Claudia, Koncarevic, Sasa, Gee, Julia Margaret Wendy

, Nicholson, Robert, Ward, Malcolm, Castellano, Leandro, Stebbing, Justin, Zucht, Hans Dieter, Sarker, Debashis, Heaton, Nigel and Pike, Ian 2014. Quantification of pancreatic cancer proteome and phosphorylome: Indicates molecular events likely contributing to cancer and activity of drug targets. PLoS ONE 9 (3) , e90948. 10.1371/journal.pone.0090948

Jordan, Nicola J.

, Dutkowski, Carol M., Barrow, Denise, Mottram, Huw J., Hutcheson, Iain R., Nicholson, Robert ., Guichard, Sylvie M. and Gee, Julia M.W.

2014. Impact of dual mTORC1/2 mTOR kinase inhibitor AZD8055 on acquired endocrine resistance in breast cancer in vitro. Breast Cancer Research 16 (1) , -. 10.1186/bcr3604

McCloy, R. A., Shelley, E. J., Roberts, C. G., Boslem, E., Biden, T. J., Nicholson, Robert Ian, Gee, Julia Margaret Wendy

, Sutherland, R. L., Musgrove, E. A., Burgess, A. and Butt, A. J. 2013. Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells. British Journal of Cancer 109 (12) , pp. 3034-3041. 10.1038/bjc.2013.693

Browne, Brigid C., Hochgräfe, Falko, Wu, Jianmin, Millar, Ewan K. A., Barraclough, Jane, Stone, Andrew, McCloy, Rachael A., Lee, Christine S., Roberts, Caroline, Ali, Naveid A., Boulghourjian, Alice, Schmich, Fabian, Linding, Rune, Farrow, Lynne, Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, O'Toole, Sandra A., Sutherland, Robert L., Musgrove, Elizabeth A., Butt, Alison J. and Daly, Roger J. 2013. Global characterization of signalling networks associated with tamoxifen resistance in breast cancer. FEBS Journal 280 (21) , pp. 5237-5257. 10.1111/febs.12441

Stone, A., Cowley, M. J., Valdes-Mora, F., McCloy, R. A., Sergio, C. M., Gallego-Ortega, D., Caldon, C. E., Ormandy, C. J., Biankin, A. V., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Print, C. G., Clark, S. J. and Musgrove, E. A. 2013. BCL-2 Hypermethylation is a potential biomarker of sensitivity to antimitotic chemotherapy in endocrine-resistant breast cancer. Molecular Cancer Therapeutics 12 (9) , pp. 1874-1885. 10.1158/1535-7163.MCT-13-0012

Robertson, John F. R., Dixon, J. Michael, Sibbering, D. Mark, Jahan, Ali, Ellis, Ian O., Channon, Eddie, Hyman-Taylor, Pauline, Nicholson, Robert Ian and Gee, Julia Margaret Wendy

2013. A randomized trial to assess the biological activity of short-term (pre-surgical) fulvestrant 500 mg plus anastrozole versus fulvestrant 500 mg alone or anastrozole alone on primary breast cancer. Breast Cancer Research 15 (2) , R18. 10.1186/bcr3393

Eccles, Suzanne A., Aboagye, Eric O., Ali, Simak, Anderson, Annie S., Armes, Jo, Berditchevski, Fedor, Blaydes, Jeremy P., Brennan, Keith, Brown, Nicola J., Bryant, Helen E., Bundred, Nigel J., Burchell, Joy M., Campbell, Anna M., Carroll, Jason S., Clarke, Robert B., Coles, Charlotte E., Cook, Gary J. R., Cox, Angela, Curtin, Nicola J., Dekker, Lodewijk V., dos Santos Silva, Isabel, Duffy, Stephen W., Easton, Douglas F., Eccles, Diana M., Edwards, Dylan R., Edwards, Joanne, Evans, D. Gareth, Fenlon, Deborah F., Flanagan, James M., Foster, Claire, Gallagher, William M., Garcia-Closas, Montserrat, Gee, Julia Margaret Wendy

, Gescher, Andy J., Goh, Vicky, Groves, Ashley M., Harvey, Amanda J., Harvie, Michelle, Hennessy, Bryan T., Hiscox, Stephen Edward

, Holen, Ingunn, Howell, Sacha J., Howell, Anthony, Hubbard, Gill, Hulbert-Williams, Nick, Hunter, Myra S., Jasani, Bharat, Jones, Louise J., Key, Timothy J., Kirwan, Cliona C., Kong, Anthony, Kunkler, Ian H., Langdon, Simon P., Leach, Martin O., Mann, David J., Marshall, John F., Martin, Lesley, Martin, Stewart G., Macdougall, Jennifer E., Miles, David W., Miller, William R., Morris, Joanna R., Moss, Sue M., Mullan, Paul, Natrajan, Rachel, O'Connor, James P. B., O'Connor, Rosemary, Palmieri, Carlo, Pharoah, Paul D. P., Rakha, Emad A., Reed, Elizabeth, Robinson, Simon P., Sahai, Erik, Saxton, John M., Schmid, Peter, Smalley, Matthew John

, Speirs, Valerie, Stein, Robert, Stingl, John, Streuli, Charles H., Tutt, Andrew N. J., Velikova, Galina, Walker, Rosemary A., Watson, Christine J., Williams, Kaye J., Young, Leonie S. and Thompson, Alastair M. 2013. Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Research 15 (5) , R92. 10.1186/bcr3493

Kalyuga, Maria, Gallego-Ortega, David, Lee, Heather J., Roden, Daniel L., Cowley, Mark J., Caldon, C. Elizabeth, Stone, Andrew, Allerdice, Stephanie L., Valdes-Mora, Fatima, Launchbury, Rosalind, Statham, Aaron L., Armstrong, Nicola, Alles, M. Chehani, Young, Adelaide, Egger, Andrea, Au, Wendy, Piggin, Catherine L, Evans, Cara J., Ledger, Anita, Brummer, Tilman, Oakes, Samantha R., Kaplan, Warren, Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Sutherland, Robert L., Swarbrick, Alexander, Naylor, Matthew J., Clark, Susan J., Carroll, Jason S. and Ormandy, Christopher J. 2012. ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. PLoS Biology 10 (12) , e1001461. 10.1371/journal.pbio.1001461

Hiscox, Stephen Edward

, Baruha, Bedanta, Smith, Chris, Bellerby, Rebecca, Goddard, Lindy, Jordan, Nicola Jane, Poghosyan, Zaruhi

, Nicholson, Robert Ian, Barrett-Lee, Peter and Gee, Julia Margaret Wendy

2012. Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan. BMC Cancer 12 , 458. 10.1186/1471-2407-12-458

Kuter, Irene, Gee, Julia Margaret Wendy

, Hegg, Roberto, Singer, Christian F., Badwe, Rajendra A., Lowe, Elizabeth S., Emeribe, Ugochi A., Anderson, Elizabeth, Sapunar, Francisco, Finlay, Pauline, Nicholson, Robert Ian, Bines, José and Harbeck, Nadia 2012. Dose-dependent change in biomarkers during neoadjuvant endocrine therapy with fulvestrant: results from NEWEST, a randomized Phase II study. Breast Cancer Research and Treatment 133 (1) , pp. 237-246. 10.1007/s10549-011-1947-7

Caldon, C. Elizabeth, Sergio, C. Marcelo, Kang, Jian, Muthukaruppan, Anita, Boersma, Marikje N., Stone, Andrew, Barraclough, Jane, Lee, Christine S., Black, Michael A., Miller, Lance D., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Sutherland, Robert L., Print, Crispin G. and Musgrove, Elizabeth A. 2012. Cyclin E2 overexpression is associated with endocrine resistance but not insensitivity to CDK2 inhibition in human breast cancer cells. Molecular Cancer Therapeutics 11 (7) , pp. 1488-1499. 10.1158/1535-7163.MCT-11-0963

Stone, Andrew, Valdés-Mora, F., Gee, Julia Margaret Wendy

, Farrow, Lynne, McClelland, Richard Andrew, Fiegl, H., Dutkowski, Carol Mary, McCloy, R. A., Sutherland, R. L., Musgrove, E. A. and Nicholson, Robert Ian 2012. Tamoxifen-induced epigenetic silencing of oestrogen-regulated genes in anti-hormone resistant breast cancer. PLoS ONE 7 (7) , e40466. 10.1371/journal.pone.0040466

Taylor, Kathryn Mary

, Gee, Julia Margaret Wendy

and Kille, Peter

2011. Zinc and cancer. Rink, Lothar, ed. Zinc in Human Health, Biomedical and Health Research, vol. 76. Amsterdam: IOS Press, pp. 283-304.

Hutcheson, Iain Robert, Goddard, Lindy, Barrow, Denise, McClelland, Richard Andrew, Francies, Hayley E., Knowlden, Janice Mary, Nicholson, Robert Ian and Gee, Julia Margaret Wendy

2011. Fulvestrant-induced expression of ErbB3 and ErbB4 receptors sensitizes oestrogen receptor-positive breast cancer cells to heregulin β1. Breast Cancer Research 13 (2) , R29. 10.1186/bcr2848

Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Barrow, Denise, Dutkowski, Carol Mary, Goddard, Lindy, Jordan, Nicola J., McClelland, Richard Andrew, Knowlden, Janice Mary, Francies, Hayley E., Hiscox, Stephen Edward

and Hutcheson, Iain Robert 2011. Antihormone induced compensatory signalling in breast cancer: an adverse event in the development of endocrine resistance. Hormone Molecular Biology and Clinical Investigation 5 (2) , pp. 67-77. 10.1515/HMBCI.2011.009

Knowlden, Janice Mary, Gee, Julia Margaret Wendy

, Barrow, Denise, Robertson, John F., Ellis, Ian O., Nicholson, Robert Ian and Hutcheson, Iain Robert 2011. erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines. Breast Cancer Research 13 (5) , R93. 10.1186/bcr3018

Nicholson, Robert Ian, Habashy, H., Gee, Julia Margaret Wendy

, Finlay, Pauline, Farrow, Lynne, Jasani, Bharat, Barrett-Lee, Peter, Robertson, J. and Ellis, Ieuan

2011. Abstract P2-06-19: Transferrin Receptor (CD71) identifies poor response to Tamoxifen in oestrogen receptor positive breast cancer patients [Abstract]. Cancer Research 70 (24 Sup) , P2-P6. 10.1158/0008-5472.SABCS10-P2-06-19

Gee, Julia Margaret Wendy

, Aleskandarany, M., Finlay, Pauline, Farrow, Lynne, Nicholson, Robert Ian, Habashy, H., Green, Adam, Rakha, E., Powell, D., Jasani, Bharat, Barrett-Lee, Peter, Robertson, J., Shaw, Victoria E. and Ellis, Ieuan

2011. Abstract P2-09-37: Immunohistochemical markers progesterone receptor, HER2, Ki67 and bcl-2-Associated Athanogene 1 and prediction of adjuvant Tamoxifen treatment outcome in ER+ early breast cancer [Abstract]. Cancer Research 70 (24 Sup) , P2-09. 10.1158/0008-5472.SABCS10-P2-09-37

Habashy, Hany O., Powe, Desmond G., Abdel-Fatah, Tarek M., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Green, Andrew R., Rakha, Emad A. and Ellis, Ian O. 2011. A review of the biological and clinical characteristics of luminal-like oestrogen receptor-positive breast cancer. Histopathology 60 (6) , pp. 854-863. 10.1111/j.1365-2559.2011.03912.x

Knowlden, Janice Mary, Gee, Julia Margaret Wendy

, Barrow, Denise, Robertson, J. F., Ellis, I. O., Nicholson, Robert Ian and Hutcheson, Iain Robert 2010. O-36 Recruitment of insulin receptor substrate-1 by erbB3 impacts on IGF-IR signalling in oestrogen receptor-positive breast cancer cells [Abstract]. EJC Supplements 8 (6) , pp. 13-14. 10.1016/j.ejcsup.2010.06.037

Knowlden, Janice Mary, Gee, Julia Margaret Wendy

, Barrow, Denise, Robertson, J. F., Ellis, I. O., Nicholson, Robert Ian and Hutcheson, Iain Robert 2010. Recruitment of insulin receptor substrate-1 by erbB3 impacts on IGF-IR signalling in oestrogen receptor-positive breast cancer cells [Abstract]. Breast Cancer Research 12 (S1) , S15. 10.1186/bcr2546

Hutcheson, Iain Robert, Goddard, Lindy, Gee, Julia Margaret Wendy

, Barrow, Denise and Nicholson, Robert Ian 2010. Fulvestrant-induced expression of erbB3 and erbB4 sensitizes ER-positive breast cancer cells to heregulins [Abstract]. Breast Cancer Research 12 (S1) , P13. 10.1186/bcr2510

Gutteridge, Eleanor, Agrawal, Amit, Nicholson, Robert Ian, Cheung, Kwok Leung, Robertson, John and Gee, Julia Margaret Wendy

2010. The effects of gefitinib in tamoxifen-resistant and hormone-insensitive breast cancer: a phase II study. International Journal of Cancer 126 (8) , pp. 1806-1816. 10.1002/ijc.24884

Robertson, J. F. R., Dixon, J. M., Sibbering, D. M., Jahan, A., Ellis, I. O., Channon, E., Nicholson, Robert Ian and Gee, Julia Margaret Wendy

2010. Biological activity of a combination of fulvestrant 500 mg (F500) plus anastrozole versus F500 alone or anastrozole alone as neoadjuvant treatment for breast cancer [Abstract]. EJC Supplements 8 (3) , p. 63. 10.1016/S1359-6349(10)70050-1

Agrawal, A., Robertson, J. F. R., Gutteridge, E., Cheung, K. L., Ellis, I. O., Nicholson, Robert Ian and Gee, Julia Margaret Wendy

2010. 182 Long-term effect of fulvestrant on hormone receptors and proliferation marker in breast cancer [Abstract]. EJC Supplements 8 (3) , p. 111. 10.1016/S1359-6349(10)70213-5

Thomas, Nicholas B. P., Hutcheson, Iain Robert, Campbell, Lee, Gee, Julia Margaret Wendy

, Taylor, Kathryn Mary

, Nicholson, Robert Ian and Gumbleton, Mark

2010. Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Research and Treatment 119 (3) , pp. 575-591. 10.1007/s10549-009-0355-8

Habashy, Hany Onsy, Powe, Desmond G., Staka, Cindy M., Rakha, Emad A., Ball, Graham, Green, Andrew R., Aleskandarany, Mohammed, Paish, E. Claire, Macmillan, R. Douglas, Nicholson, Robert Ian, Ellis, Ian O. and Gee, Julia Margaret Wendy

2010. Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen. Breast Cancer Research and Treatment 119 (2) , pp. 283-293. 10.1007/s10549-009-0345-x

Blamey, R. W., Hornmark-Stenstam, B., Ball, G., Blichert-Toft, M., Cataliotti, L., Fourquet, A., Gee, Julia Margaret Wendy

, Holli, K., Jakesz, R., Kerin, M., Mansel, Robert Edward

, Nicholson, Robert Ian, Pienkowski, T., Pinder, S., Sundquist, M., van de Vijver, M. and Ellis, I. 2010. ONCOPOOL - A European database for 16,944 cases of breast cancer. European Journal of Cancer 46 (1) , pp. 56-71. 10.1016/j.ejca.2009.09.009

Robertson, J. F. R., Dixon, J. M., Sibbering, D. M., Jahan, A., Ellis, I. O., Channon, E. J., Nicholson, Robert Ian and Gee, Julia Margaret Wendy

2009. Tumor biomarker changes following pre-surgical treatment with 500 mg Fulvestrant plus Anastrozole Versus 500 mg Fulvestrant Alone and 1 mg Anastrozole Alone [Abstract]. Cancer Research 69 (24S) , 491S. 10.1158/0008-5472.SABCS-09-24

Morgan, Liam David

, Gee, Julia Margaret Wendy

, Pumford, Sara Louise, Farrow, Lynne, Finlay, Pauline, Robertson, John, Ellis, Ian, Kawakatsu, Hisaaki, Nicholson, Robert Ian and Hiscox, Stephen Edward

2009. Elevated Src kinase activity attenuates tamoxifen response in vitro and is associated with poor prognosis clinically. Cancer Biology and Therapy 8 (16) , pp. 1550-1558. 10.4161/cbt.8.16.8954

Kuter, I., Anderson, E., Emeribe, U., Finlay, Pauline, Nicholson, Robert Ian and Gee, Julia Margaret Wendy

2009. Comparison of methods for detection of fulvestrant-induced changes in breast tumor estrogen and progesterone receptor expression in a neoadjuvant trial (NEWEST) [Abstract]. Journal of Clinical Oncology 27 (15S) , e11602.

Elsheikh, S. E., Green, A. R., McClelland, Richard Andrew, Hutcheson, Iain Robert, Gee, Julia Margaret Wendy

, Nicholson, Robert Ian and Ellis, I. O. 2009. 162 Altered Histone Modifications and their regulating enzymes in Fulvestrant resistant breast cancer cell line In Vitro [Abstract]. Laboratory Investigation 89 (S1) , 38A-39A. 10.1038/labinvest.2008.132

Nicholson, Robert Ian, Hutcheson, Iain Robert, Hiscox, Stephen Edward

, Taylor, Kathryn Mary

and Gee, Julia Margaret Wendy

2009. Experimental endocrine resistance: concepts and strategies. Hiscox, Stephen Edward, Gee, Julia Margaret Wendy and Nicholson, Robert Ian, eds. Therapeutic Resistance to Anti-Hormonal Drugs in Breast Cancer: New Molecular Aspects and their Potential, Dordrecht: Springer, pp. 1-26. (10.1007/978-1-4020-8526-0_1)

Gee, Julia Margaret Wendy

, Stone, Andrew, McClelland, Richard Andrew, Hiscox, Stephen Edward

, Hutcheson, Iain Robert, Jordan, Nicola J., Fiegl, Heidi M., Widschwendter, Martin, Shaw, Victoria E., Barrow, Denise and Nicholson, Robert Ian 2009. The dark side of antihormonal action in breast cancer. Hiscox, Stephen Edward, Gee, Julia Margaret Wendy and Nicholson, Robert Ian, eds. Therapeutic Resistance to Anti-Hormonal Drugs in Breast Cancer: New Molecular Aspects and their Potential, Dordrecht: Springer, pp. 63-84. (10.1007/978-1-4020-8526-0_4)

Hiscox, Stephen Edward

, Jordan, Nicola Jane, Morgan, Liam David

, Smith, Christopher, Goddard, Lindy, Gee, Julia Margaret Wendy

and Nicholson, Robert 2009. Adverse features of acquired antihormone resistance and their targeting. Hiscox, Stephen Edward, Gee, Julia Margaret Wendy and Nicholson, Robert, eds. Therapeutic Resistance to Anti-Hormonal Drugs in Breast Cancer: New Molecular Aspects and their Potential as Targets, London: Springer, pp. 139-160. (10.1007/978-1-4020-8526-0_8)

Gee, Julia Margaret Wendy

, Eloranta, J. J., Ibbitt, J. C., Robertson, J. F. R., Ellis, I. O., Williams, T., Nicholson, Robert Ian and Hurst, H. C. 2009. Overexpression of TFAP2C in invasive breast cancer correlates with a poorer response to anti-hormone therapy and reduced patient survival. The Journal of Pathology 217 (1) , pp. 32-41. 10.1002/path.2430

Hiscox, Stephen Edward

, Jordan, Nicola Jane, Crandon-Lewis, A., Jiang, W., Nicholson, Robert Ian and Gee, Julia Margaret Wendy

2009. Overexpression of L1CAM accompanies acquired endocrine resistance and is associated with the development of an aggressive cell phenotype [Abstract]. Cancer Research 69 (2) , 213S-213S. 10.1158/0008-5472.SABCS-3028

Shou, J., Osborne, K. C., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian and Schiff, R. 2009. Akt-dependent phosphorylation on AIB1 serine 967 contributes to breast cancer tamoxifen resistance [Abstract]. Cancer Research 69 (2) , 211S-211S. 10.1158/0008-5472.SABCS-3021

Elsheikh, S. E., Green, A. R., McClelland, Richard Andrew, Hutcheson, Iain Robert, Gee, Julia Margaret Wendy

, Nicholson, Robert Ian and Ellis, I. O. 2009. Altered Histone Modifications and Their Regulating Enzymes in Fulvestrant Resistant Breast Cancer Cell Line In Vitro [Abstract]. Modern Pathology 22 (S1) , 38A-39A. 10.1038/modpathol.2008.210

Jasani, Bharat, Gee, Julia Margaret Wendy

, Hutcheson, Iain Robert, Clarkson, Richard W. E.

, Bartlett, J. and Barrett-Lee, Peter 2009. Resistance to HER2-directed trastuzumab therapy in breast cancer. Advances in Breast Cancer 6 (3) , pp. 11-18.

Kuter, I., Anderson, E., Emeribe, U., Finlay, Pauline, Nicholson, Robert Ian and Gee, Julia Margaret Wendy

2009. Comparison of Methods for Detection of Fulvestrant-Induced Changes in Breast Tumor Estrogen and Progesterone Receptor Expression in a Neoadjuvant Trial (NEWEST). Cancer Research 69 (24) , 566S-567S.

O'Brien, C. S., Howell, S. J., Gee, Julia Margaret Wendy

, Lykkesfeldt, A. E., Nicholson, Robert Ian and Clarke, R. B. 2009. Tamoxifen resistance in Estrogen Receptor Positive (ER plus ) breast cancer is driven by Estrogen Receptor Negative (ER-) cancer stem-like cells [Abstract]. Cancer Research 69 (24) , 807S.

Law, Jennifer H., Habibi, Golareh, Hu, Kaiji, Masoudi, Hamid, Wang, Michelle. Y. C., Stratford, Anna L., Park, Eugene, Gee, Julia Margaret Wendy

, Finlay, Pauline, Jones, Helen E., Nicholson, Robert Ian, Carboni, Joan, Gottardis, Marco, Pollak, Michael and Dunn, Sandra E. 2008. Phosphorylated insulin-like growth factor-I/insulin receptor is present in all breast cancer subtypes and is related to poor survival. Cancer Research 68 (24) , pp. 10238-10246. 10.1158/0008-5472.CAN-08-2755

Davison, Zoe, Dutkowski, Carol Mary, Gee, Julia Margaret Wendy

, Nicholson, Robert Ian and Heard, Charles Martin

2008. In vitro effects on MCF-7 breast cancer cells of signal transduction inhibitor/tamoxifen/eicosapentaenoic acid combinations and their simultaneous delivery across skin. Pharmaceutical Research 25 (11) , pp. 2516-2525. 10.1007/s11095-008-9665-5

Knowlden, Janice Mary, Jones, Helen E., Barrow, Denise, Gee, Julia Margaret Wendy

, Nicholson, Robert Ian and Hutcheson, Iain Robert 2008. Insulin receptor substrate-1 involvement in epidermal growth factor receptor and insulin-like growth factor receptor signalling: implication for Gefitinib ('Iressa') response and resistance. Breast Cancer Research and Treatment 111 (1) , pp. 79-91. 10.1007/s10549-007-9763-9

Hiscox, Stephen Edward

, Goddard, Lindy, Jordan, Nicola Jane, Smith, Chris, Harper, Maureen Elaine, Nicholson, Robert Ian and Gee, Julia Margaret Wendy

2008. Overexpression of CD44 in acquired tamoxifen-resistant breast cancer cells augments their migratory response to heregulin beta 1 [Abstract]. Breast Cancer Research 10 (S2) , P34. 10.1186/bcr1918

Stone, A., Jones, H., Giles, M., Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 2008. Anti-oestrogen therapy switches off tumour suppressors and proapoptotic genes in breast cancer and reveals a new therapeutic opportunity [Abstract]. Breast Cancer Research 10 (s2) , P41. 10.1186/bcr1925

Bensmail, Abdelwahab, Hutcheson, Iain Robert, Giles, M., Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 2008. Loss of oestrogen receptor alpha in long-term antioestrogen-resistant cells: reversal by a c-src inhibitor [Abstract]. Breast Cancer Research 10 (S2) , O3. 10.1186/bcr1883

Borley, Annabel Catherine, Hiscox, Stephen Edward

, Gee, Julia Margaret Wendy

, Smith, Chris, Shaw, Victoria, Barrett-Lee, Peter and Nicholson, Robert Ian 2008. Anti-oestrogens but not oestrogen deprivation promote cellular invasion in intercellular adhesion-deficient breast cancer cells. Breast Cancer Research 10 (6) , R103. 10.1186/bcr2206

Habashy, H. O., Powe, D. G., Rakha, E. A., Ball, G., Paish, C., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian and Ellis, I. O. 2008. Forkhead-box A1 (FOXA1) expression in breast cancer and its prognostic significance. European Journal of Cancer 44 (11) , pp. 1541-1551. 10.1016/j.ejca.2008.04.020

Rakha, E. A., El-Sayed, M. E., Powe, D. G., Green, A. R., Habashy, H., Grainge, M. J., Robertson, J. F. R., Blamey, R., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Lee, A. H. S. and Ellis, I. O. 2008. Invasive lobular carcinoma of the breast: Response to hormonal therapy and outcomes. European Journal of Cancer 44 (1) , pp. 73-83. 10.1016/j.ejca.2007.10.009

Taylor, Kathryn Mary

, Jordan, Nicola JAne, Hiscox, Stephen Edward

, Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 2008. Zinc transporter HKE4 as a new target in antihormone resistance of breast cancer [Abstract]. Breast Cancer Research 10 (s2) , P42. 10.1186/bcr1926

Thompson, A., Brennan, K., Cox, A., Gee, Julia Margaret Wendy

, Harcourt, D., Harris, A., Harvie, M., Holen, I., Howell, A., Nicholson, Robert Ian, Steel, M. and Streuli, C. 2008. Evaluation of the current knowledge limitations in breast cancer research: a gap analysis. Breast Cancer Research 10 (2) , R26. 10.1186/bcr1983

Nicholson, Robert Ian, Hutcheson, Iain Robert, Jones, Helen Elizabeth, Taylor, Kathryn Mary

, Hiscox, Stephen Edward

and Gee, Julia Margaret Wendy

2008. Compensatory signalling induced by anti-hormone and anti-growth factor therapies in breast cancer: a starting point for the development of resistance to targeted therapies. Pasqualini, Jorge R., ed. Breast cancer: prognosis, treatment and prevention. 2nd ed, London: Informa Healthcare, pp. 123-136.

Hutcheson, Iain Robert, Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 2008. MAP Kinase family members and endocrine response and survival in breast cancer. Walker, Rosemary A. and Thompson, Alastair M., eds. Prognostic and predictive factors in breast cancer. 2nd ed., London: Informa Healthcare, pp. 122-138.

Borley, A. C., Barrett-Lee, Peter, Gee, Julia Margaret Wendy

, Show, V. E., Nicholson, Robert and Hiscox, Stephen Edward

2007. Anti-estrogens promote an invasive phenotype in intercellular adhesion deficient breast cancer cells. Breast Cancer Research and Treatment 106 (Supp 1) , S7-S8.

Rampaul, R. S., Ball, G., Paish, C., Pinder, S. E., Mitchell, M. J., Blamey, R. W., Robertson, J. F. R., Nicholson, Robert Ian, Gee, Julia Margaret Wendy

, Gullick, W. J. and Ellis, I. O. 2007. O-105 erbB Signalling in breast cancer. EJC Supplements 5 (3) , p. 32. 10.1016/S1359-6349(07)71795-0

Assender, J. W., Gee, Julia Margaret Wendy

, Lewis, I., Ellis, I. O., Robertson, J. F. R. and Nicholson, Robert Ian 2007. Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer. Journal of Clinical Pathology 60 (11) , pp. 1216-1221. 10.1136/jcp.2006.041616

Greco, F., Vicent, M. J., Gee, S., Jones, Arwyn Tomos

, Gee, Julia Margaret Wendy

, Nicholson, Robert Ian and Duncan, Ruth 2007. Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells. Journal of Controlled Release 117 (1) , pp. 28-39. 10.1016/j.jconrel.2006.10.012

Hutcheson, Iain Robert, Knowlden, Janice Mary, Hiscox, Stephen Edward

, Barrow, Denise, Gee, Julia Margaret Wendy

, Robertson, J. F., Ellis, I. O. and Nicholson, Robert Ian 2007. Heregulin beta 1 drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells. Breast Cancer Research 9 (4) , R50. 10.1186/bcr1754

Nicholson, Robert Ian, Hutcheson, Iain Robert, Jones, H. E., Hiscox, Stephen Edward

, Giles, M., Taylor, Kathryn Mary

and Gee, Julia Margaret Wendy

2007. Growth factor signalling in endocrine and anti-growth factor resistant breast cancer. Reviews in Endocrine and Metabolic Disorders 8 (3) , pp. 241-253. 10.1007/s11154-007-9033-5

Rakha, E. A., El-Sayed, M. E., Green, A. R., Paish, E. C., Powe, D. G., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Lee, A. H. S., Robertson, J. F. R. and Ellis, I. O. 2007. Biologic and clinical characteristics of breast cancer with single hormone receptor-positive phenotype. Journal of Clinical Oncology 25 (30) , pp. 4772-4778. 10.1200/jco.2007.12.2747

Rampaul, R. S., Paish, C., Pinder, S. E., Going, J. J., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Robertson, J. F. and Ellis, I. O. 2007. Assessment of Her-2 status using a panel of antibodies and FISH. EJC Supplements 5 (3) , p. 17.

Robertson, J. F. R., Semiglazov, V., Nemsadze, G., Dzagnidze, G., Janjalia, M., Nicholson, Robert Ian, Gee, Julia Margaret Wendy

and Armstrong, J. 2007. Effects of fulvestrant 250 mg in premenopausal women with oestrogen receptor-positive primary breast cancer. European Journal of Cancer 43 (1) , pp. 64-70. 10.1016/j.ejca.2006.08.019

Hutcheson, Iain Robert, Knowlden, Janice Mary, Jones, Helen E., Burmi, R. S., McClelland, Richard Andrew, Barrow, Denise, Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 2006. Inductive mechanisms limiting response to anti-epidermal growth factor receptor therapy. Endocrine-Related Cancer 13 (S1) , S89-S97. 10.1677/erc.1.01279

Gee, Julia Margaret Wendy

, Shaw, Victoria E., Hiscox, Stephen Edward

, McClelland, Richard Andrew, Rushmere, N. K. and Nicholson, Robert Ian 2006. Deciphering antihormone-induced compensatory mechanisms in breast cancer and their therapeutic implications. Endocrine-Related Cancer 13 (S1) , S77-S88. 10.1677/erc.1.01274

Jones, Helen E., Gee, Julia Margaret Wendy

, Hutcheson, Iain Robert, Knowlden, Janice Mary, Barrow, Denise and Nicholson, Robert Ian 2006. Growth factor receptor interplay and resistance in cancer. Endocrine-Related Cancer 13 (S1) , S45-S51. 10.1677/erc.1.01275

Nicholson, Robert Ian, Gee, Julia Margaret Wendy

, Harris, A. and Anderson, E. 2006. Consensus Statement. Endocrine-Related Cancer 13 (S1) , S1-S2. 10.1677/erc.1.01323

Burmi, Rajpal Singh, McClelland, Richard Andrew, Barrow, Denise, Ellis, I. O., Robertson, J. F. R., Nicholson, Robert Ian and Gee, Julia Margaret Wendy

2006. Microarray studies reveal novel genes associated with endocrine resistance in breast cancer [Abstract]. Breast Cancer Research 8 (S2) , S11. 10.1186/bcr1554

Sarwar, N., Kim, J. S., Jiang, J., Peston, D., Sinnett, H. D., Madden, P., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Lykkesfeldt, A. E., Shousha, S., Coombes, R. C. and Ali, S. 2006. Phosphorylation of ER alpha at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ER alpha phosphorylation in breast cancer progression. Endocrine-Related Cancer 13 (3) , pp. 851-861. 10.1677/erc.1.01123

Jones, Helen E., Gee, Julia Margaret Wendy

, Barrow, Denise, Tonge, D., Holloway, B. and Nicholson, Robert Ian 2006. Inhibition of insulin receptor isoform-A signalling restores sensitivity to gefitinib in previously de novo resistant colon cancer cells. British Journal of Cancer 95 (2) , pp. 172-180. 10.1038/sj.bjc.6603237

Jones, Helen E., Gee, Julia Margaret Wendy

, Hutcheson, Iain Robert and Nicholson, Robert Ian 2006. Growth factor pathway switching: implications for the use of gefitinib and trastuzumab. Breast Cancer Online 9 (7) , e27. 10.1017/S1470903106005451

Hiscox, Stephen Edward

, Morgan, Liam David

, Green, Tim P., Barrow, Denise, Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 2006. Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells. Breast cancer research and treatment 97 (3) , pp. 263-274. 10.1007/s10549-005-9120-9

Britton, David James, Hutcheson, Iain Robert, Knowlden, Janice Mary, Barrow, Denise, Giles, Martin Gwyn, McClelland, Richard Andrew, Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 2006. Bidirectional cross talk between ER alpha and EGFR signalling pathways regulates tamoxifen-resistant growth. Breast Cancer Research and Treatment 96 (2) , pp. 131-146. 10.1007/s10549-005-9070-2

Jasani, Bharat, Douglas-Jones, Anthony Gordon, Rhodes, Anthony, Wozniak, Susan, Barrett-Lee, Peter, Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 2006. Measurement of estrogen receptor status by immunocytochemistry in paraffin wax sections. Brooks, S. A. and Harris, A., eds. Breast Cancer Research Protocols, Methods in Molecular Medicine, vol. 120. Totowa, NJ: Humana Press, pp. 127-146. (10.1385/1-59259-969-9:127)

Jones, Helen E., Gee, Julia Margaret Wendy

, Barrow, Denise, Holloway, B., Tonge, D. and Nicholson, Robert Ian 2006. Maintenance of EGFR phosphorylation by the IGF-1R in the presence of gefitinib in lung cancer cells: Co-targeting the EGFR and IGF-1R maximises anti-tumour effects [Abstract]. Annals of Oncology 17 (S3) , iii39. 10.1093/annonc/mdl919

Ali, S., Sarwar, N., Jiang, J., Peston, D., Sinnett, H. D., Madden, P., Shousha, S., Lykkesfeldt, A. E., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Kulinskaya, E. and Coombes, R. C. 2006. Immunohistochemical determination of estrogen receptor-alpha phosphorylation in activation function AF1 in primary and tamoxifen-resistant breast cancer is indicative of a complex role for estrogen receptor-alpha phosphorylation in breast cancer progression [Abstract]. Breast Cancer Research and Treatment 100 (S1) , S36-S37. 10.1007/s10549-006-5678-0

Knowlden, Janice Mary, Hutcheson, Iain Robert, Barrow, Denise, Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 2005. Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: A supporting role to the epidermal growth factor receptor. Endocrinology 146 (11) , pp. 4609-4618. 10.1210/en.2005-0247

Nicholson, Robert Ian, Hutcheson, Iain Robert, Hiscox, Stephen Edward

, Knowlden, Janice Mary, Giles, Martin Gwyn, Barrow, Denise and Gee, Julia Margaret Wendy

2005. Growth factor signalling and resistance to selective oestrogen receptor modulators and pure anti-oestrogens: the use of anti-growth factor therapies to treat or delay endocrine resistance in breast cancer. Endocrine-Related Cancer 12 (S1) , S29-S36. 10.1677/erc.1.00991

Gee, Julia Margaret Wendy

, Howell, A., Gullick, W. J., Benz, C. C., Sutherland, R. L., Santen, R. J., Martin, L. A., Ciardiello, F., Miller, W. R., Dowsett, M., Barrett-Lee, Peter, Robertson, J. F. R., Johnston, S. R., Jones, Helen E., Wakeling, A. E., Duncan, R. and Nicholson, Robert Ian 2005. Consensus statement. Endocrine-Related Cancer 12 (S1) , S1-S7. 10.1677/erc.1.01054

Jones, Helen E., Gee, Julia Margaret Wendy

, Taylor, Kathryn Mary

, Barrow, Denise, Williams, Hywel David, Rubini, M. and Nicholson, Robert Ian 2005. Development of strategies for the use of anti-growth factor treatments. Endocrine-Related Cancer 12 (S1) , S173-S182. 10.1677/erc.1.01004

Agrawal, A., Gutteridge, E., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian and Robertson, J. F. R. 2005. Overview of tyrosine kinase inhibitors in clinical breast cancer. Endocrine-Related Cancer 12 (S1) , S135-S144. 10.1677/erc.1.01059

Staka, Cindy M., Nicholson, Robert Ian and Gee, Julia Margaret Wendy

2005. Acquired resistance to oestrogen deprivation: role for growth factor signalling kinases/oestrogen receptor cross-talk revealed in new MCF-7X model. Endocrine-Related Cancer 12 (S1) , S85-S97. 10.1677/erc.1.01006

Gee, Julia Margaret Wendy

, Robertson, J. F., Gutteridge, E., Ellis, I. O., Pinder, S. E., Rubini, M. and Nicholson, Robert Ian 2005. Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer. Endocrine-Related Cancer 12 (S1) , S99-S111. 10.1677/erc.1.01005

Gutteridge, E., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian and Robertson, J. F. R. 2005. Biological markers associated with response to gefitinib ('Iressa') in patients with breast cancer [Abstract]. British Journal of Surgery 92 (S1) , pp. 13-17. 10.1002/bjs.5008

Green, A. R., Paish, E. C., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Cheung, K. L., Robertson, J. F. R. and Ellis, I. O. 2005. Oestrogen receptor variant expression as potential selectors for adjuvant endocrine therapy in breast cancer patients [Abstract]. Journal of Pathology 205 (S1) , 5A. 10.1002/path.1762

Nicholson, Robert Ian, Hutcheson, Iain Robert, Britton, David James, Knowlden, Janice Mary, Jones, Helen E., Harper, Maureen Elaine, Hiscox, Stephen Edward

, Barrow, Denise and Gee, Julia Margaret Wendy

2005. Growth factor signalling networks in breast cancer and resistance to endocrine agents: new therapeutic strategies. The Journal of Steroid Biochemistry and Molecular Biology 93 (2-5) , pp. 257-262. 10.1016/j.jsbmb.2004.12.006

Gee, Julia Margaret Wendy

and Hutcheson, Iain Robert 2005. Understanding endocrine resistance: the critical need for sequential samples from clinical breast cancer and novel in vitro models [Viewpoint]. Breast Cancer Research 7 (5) , pp. 187-189. 10.1186/bcr1289

Giles, Martin Gwyn, Fiegl, H., Widschwendter, M., Gee, Julia Margaret Wendy

, Wakeling, A. E. and Nicholson, Robert Ian 2005. Loss of estrogen receptor (ER) expression in MCF-7 cells following long-term exposure to fulvestrant [Abstract]. Breast Cancer Research and Treatment 94 (S1) , S243. 10.1007/s10549-005-1234-6

Nicholson, Robert Ian, Staka, C., Boyns, Frances Elizabeth, Hutcheson, Iain Robert and Gee, Julia Margaret Wendy

2004. Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapy. Endocrine-Related Cancer 11 (4) , pp. 623-641. 10.1677/erc.1.00778

Jones, Helen E., Goddard, Lindy, Gee, Julia Margaret Wendy

, Hiscox, Stephen Edward

, Rubini, M., Barrow, Denise, Knowlden, Janice Mary, Williams, Sophie E., Wakeling, A. E. and Nicholson, Robert Ian 2004. Insulin-like growth factor-1 receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells. Endocrine-Related Cancer 11 (4) , pp. 793-814. 10.1677/erc.1.00799

Jordan, Nicola Jane, Gee, Julia Margaret Wendy

, Barrow, Denise, Wakeling, A. E. and Nicholson, Robert Ian 2004. Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells. Breast Cancer Research and Treatment 87 (2) , pp. 167-180. 10.1023/B:BREA.0000041623.21338.47

Gutteridge, E., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian and Robertson, J. F. R. 2004. Biological markers associated with response to gefitinib (ZD1839) in patients with breast cancer [Abstract]. Journal of Clinical Oncology 22 (14S) , 648.

Rushmere, N. K., Knowlden, Janice Mary, Gee, Julia Margaret Wendy

, Harper, Maureen Elaine, Robertson, J. F. R., Morgan, Bryan Paul

and Nicholson, Robert Ian 2004. Analysis of the level of mRNA expression of the membrane regulators of complement, Cd59, Cd55 and Cd46, in breast, cancer. International Journal of Cancer 108 (6) , pp. 930-936. 10.1002/ijc.11606

Hutcheson, Iain Robert, Gee, Julia Margaret Wendy

, Barrow, Denise, Jones, Helen E., Wakeling, A. E. and Nicholson, Robert Ian 2004. Treatment of tamoxifen-resistant MCF-7 breast cancer cells with either gefitinib ('Iressa') or trastuzumab (Herceptin((R))) generates cross-resistant phenotypes [Abstract]. Breast Cancer Research and Treatment 88 (S1) , S145-S146. 10.1007/s10549-004-3602-z

Nicholson, Robert, Hutcheson, Iain Robert, Knowlden, Janice Mary, Jones, Helen E., Harper, Maureen Elaine, Jordan, Nicola Jane, Hiscox, Stephen Edward

, Barrow, Denise and Gee, Julia Margaret Wendy

2004. Nonendocrine pathways and endocrine resistance: observations with antiestrogens and signal transduction inhibitors in combination. Clinical Cancer Research 10 (1) , 346s-354s. 10.1158/1078-0432.CCR-031206

Gee, Julia Margaret Wendy

, Gutteridge, E., Robertson, J. F., Wakeling, A. E., Jones, Helen E. and Nicholson, Robert Ian 2004. Biological markers during early treatment of tamoxifen resistant breast cancer with gefitinib ('Iressa')[Abstract]. Breast Cancer Research and Treatment 88 (S1) , S32. 10.1007/s10549-004-3602-z

Gee, Julia Margaret Wendy

, Giles, Martin Gwyn and Nicholson, Robert Ian 2004. Extreme growth factor signalling can promote oestrogen receptor-alpha loss: therapeutic implications in breast cancer. Breast Cancer Research 6 (4) , pp. 162-163. 10.1186/bcr904

Giles, Martin Gwyn, Gee, Julia Margaret Wendy

, Wakeling, A. E. and Nicholson, Robert Ian 2004. Characterization of ER alpha and cofactor recruitment during fulvestrant treatment and resistance in breast cancer using chromatin immunoprecipitation [Abstract]. Breast Cancer Research and Treatment 88 (S1) , S216-S217. 10.1007/s10549-004-3602-z

Nicholson, Robert, Hutcheson, Iain Robert, Knowlden, Janice Mary, Britton, David James, Harper, Maureen Elaine, Jordan, Nicola Jane, Hiscox, Stephen Edward

, Barrow, Denise and Gee, Julia Margaret Wendy

2004. Chapter 16: beyond antihormones in the targeted therapy of breast cancer. Ingle, James N. and Dowsett, Mitchell, eds. Endocrine Therapy for Breast Cancer Proceedings of the 2003 Gleneagles Conference, New York: Marcel Dekker, pp. 249-258.

Gee, Julia Margaret Wendy

, Harper, ME, Hurcheson, IR and Madden, TA 2003. The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro. Endocrinology 144 (11) , pp. 5105-5117. 10.1210/en.2003-0705

Hutcheson, Iain Robert, Knowlden, Janice Mary, Madden, Tracie-Ann

, Barrow, Denise, Gee, Julia Margaret Wendy

, Wakeling, A. E. and Nicholson, Robert Ian 2003. Oestrogen receptor-mediated modulation of the EGFR/MAPK pathway in tamoxifen-resistant MCF-7 cells. Breast Cancer Research and Treatment 81 (1) , pp. 81-93. 10.1023/A:1025484908380

Knowlden, Janice Mary, Hutcheson, Iain Robert, Jones, Helen E., Madden, Tracie-Ann

, Gee, Julia Margaret Wendy

, Harper, Maureen Elaine, Barrow, Denise, Wakeling, A. E. and Nicholson, Robert Ian 2003. Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 144 (3) , pp. 1032-1044. 10.1210/en.2002-220620

Britton, D. J., Hutcheson, Iain Robert, Barrow, Denise, McClelland, Richard Andrew, Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 2003. Oestrogen receptor phosphorylation in hormone sensitive and anti-hormone resistant breast cancer cells [Abstract]. Breast Cancer Research and Treatment 82 (S1) , S61. 10.1023/A:1026252325164

Nicholson, Robert Ian, Gee, Julia Margaret Wendy

, Knowlden, Janice Mary, McClelland, Richard Andrew, Madden, Tracie-Ann

, Barrow, Denise and Hutcheson, Iain Robert 2003. The biology of antihormone failure in breast cancer. Breast Cancer Research and Treatment 80 (S1) , pp. 29-34. 10.1023/A:1025467500433

Nicholson, Robert Ian, Jones, Helen E., Gee, Julia Margaret Wendy

, Barrow, Denise, Hiscox, Stephen Eward

, Harper, Maureen Elaine, Rubini, M., Guy, S. and Wakeling, A. E. 2003. Insulin-like growth factor-1 receptor signalling and acquired resistance to gefitinib ('Iressa', ZD1839) in MCF-7 human breast cancer cells [Abstract]. Breast Cancer Research and Treatment 82 (S1) , S171. 10.1023/A:1026252325164

Hutcheson, Iain Robert, Knowlden, Janice Mary, Barrow, Denise, Gee, Julia Margaret Wendy

, Robertson, J. F., Wakeling, A. E. and Nicholson, Robert Ian 2003. Heregulin-induced AKT activation promotes growth of gefitinib ('Iressa', ZD1839)-treated, tamoxifen-resistant breast cancer cells [Abstract]. Breast Cancer Research and Treatment 82 (S1) , S170. 10.1023/A:1026252325164

Gee, Julia Margaret Wendy

, Rubini, M., Robertson, J. F., Ellis, I. O., Gutteridge, E. and Nicholson, Robert Ian 2003. Type 1 insulin-like growth factor receptor expression and activation in clinical breast cancer [Abstract]. Breast Cancer Research and Treatment 82 (S1) , S102. 10.1023/A:1026252325164

Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 2003. Expanding the therapeutic repertoire of epidermal growth factor receptor blockade: radiosensitization [Commentary]. Breast Cancer Research 5 (3) , pp. 126-129. 10.1186/bcr584

Gee, Julia Margaret Wendy

and Knowlden, Janice Mary 2003. ADAM metalloproteases and EGFR signalling [Viewpoint]. Breast Cancer Research 5 (5) , pp. 223-224. 10.1186/bcr637

Hutcheson, Iain Robert, Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 2003. MAP Kinase family members and endocrine response and survival in breast cancer. Walker, R. A., ed. Prognostic and Predictive Factors in Breast Cancer, London: Martin Dunitz, pp. 147-166.

Gee, Julia Margaret Wendy

, Harper, Maureen Elaine, Hutcheson, Iain Robert, Madden, Tracie-Ann

, Barrow, Denise, Knowlden, Janice Mary, McClelland, Richard Andrew, Jordan, Nicola Jane, Wakeling, A. E. and Nicholson, Robert Ian 2002. ZD1839 ('Iressa') improves the antitumour activity of tamoxifen ('Nolvadex') and ICI 182, 780 ('Faslodex') in antihormone responsive breast cancer [Abstract]. European Journal of Cancer 38 (S7) , S59. 10.1016/S0959-8049(02)80835-8

Nicholson, Robert Ian, Hutcheson, Iain Robert and Gee, Julia Margaret Wendy

2002. Targeting of oestrogen and growth factor signalling pathways in the therapy of breast cancer: Implications for chemoprevention [Abstract]. European Journal of Cancer 38 (S3) , S43-S44. 10.1016/S0959-8049(02)81245-X

Nicholson, Robert Ian, Hutcheson, Iain Robert, Harper, Maureen Elaine, Knowlden, Janice Mary, Barrow, Denise, McClelland, Richard Andrew, Jones, Helen E., Wakeling, A. E. and Gee, Julia Margaret Wendy

2002. Modulation of epidermal growth factor receptor in endocrine-resistant, estrogen-receptor-positive breast cancer. Castagnetta, L., Agostara, B., Massimo, L., Montalto, G. and Bradlow, H. L., eds. Hormone-Related Tumors: Novel Approaches to Prevention and Treatment, Annals of the New York Academy of Sciences, vol. 963. New York: The New York Academy of Sciences, pp. 104-115. (10.1111/j.1749-6632.2002.tb04101.x)

Albanell, Joan, Rojo, Federico, Averbuch, Steve, Feyereislova, Andrea, Mascaro, Jose Manuel, Herbst, Roy, Lo Russo, Patricia, Rischin, Danny, Sauleda, Silvia, Gee, Julia Margaret Wendy

, Nicholson, Robert Ian and Baselga, Jose 2002. Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: histopathologic and molecular consequences of receptor inhibition. Journal of Clinical Oncology 20 (1) , pp. 110-124. 10.1200/JCO.20.1.110

Chan, Kai C., Knox, W. Fiona, Gee, Julia Margaret Wendy

, Morris, Julia, Nicholson, Robert Ian, Potten, Christopher S. and Bundred, Nigel J. 2002. Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast. Cancer Research 62 , pp. 122-128.

Wakeling, A. E., Nicholson, Robert Ian and Gee, Julia Margaret Wendy

2001. Prospects for combining hormonal and nonhormonal growth factor inhibition. Clinical Cancer Research 7 (12) , 4350S-4355S.

Nicholson, Robert Ian, Harper, Maureen Elaine, Hutcheson, Iain Robert, Madden, Tracie-Ann

, Barrow, Denise, Knowlden, Janice Mary, Jordan, Nicola Jane, Wakeling, A. E. and Gee, Julia Margaret Wendy

2001. ZD1839 (Iressa) improves the antitumor activity of tamoxifen (Nolvadex) in antihormone-responsive breast cancer cells [Abstract]. Clinical Cancer Research 7 (S) , 3766S.

Glynne-Jones, Eveline Marie, Harper, Maureen Elaine, Seery, Liam Thomas, James, Rhianedd, Anglin, Ian Edward, Morgan, Helen E., Taylor, Kathryn Mary

, Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 2001. TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence. International Journal of Cancer 94 (2) , pp. 178-184. 10.1002/ijc.1450

Nicholson, Robert Ian, Gee, Julia Margaret Wendy

and Harper, Maureen Elaine 2001. EGFR and cancer prognosis. European Journal of Cancer 37 (S4) , pp. 9-15. 10.1016/S0959-8049(01)00231-3

2001. Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer. Endocrine-Related Cancer 8 (3) , pp. 175-182. 10.1677/erc.0.0080175

Robertson, J. F., Nicholson, Robert Ian, Bundred, N. J., Anderson, E., Rayter, Z., Dowsett, M., Fox, J. N., Gee, Julia Margaret Wendy

, Webster, A., Wakeling, A. E., Morris, C. and Dixon, M. 2001. Comparison of the short-term biological effects of 7 alpha-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)-nonyl]estra-1,3,5, (10)-triene-3,17 beta-diol (Faslodex) versus tamoxifen in postmenopausal women with primary breast cancer. Cancer Research 61 (18) , pp. 6739-6746.

McClelland, Richard Andrew, Barrow, Denise, Madden, Tracie-Ann

, Dutkowski, Carol Mary, Pamment, Joanna Susan, Knowlden, Janice Mary, Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 2001. Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex). Endocrinology 142 (7) , pp. 2776-2788. 10.1210/en.142.7.2776

Gee, Julia Margaret Wendy

, Ellis, IO, Nicholson, RI and Robertson, JF 2001. Phosphorylation of ERK1/2 mitogen-activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer. International Journal of Cancer 95 (4) , pp. 247-54. 10.1002/1097-0215(20010720)95:4<247::AID-IJC1042>3.0.CO;2-S

Kenny, F. S., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Ellis, I. O., Morris, T. M., Watson, S. A., Bryce, R. P. and Robertson, J. F. R. 2001. Effect of dietary GLA plus /-tamoxifen on the growth, ER expression and fatty acid profile of ER positive human breast cancer xenografts. International Journal of Cancer 92 (3) , pp. 342-347. 10.1002/ijc.1213

Kenny, F. S., Willsher, P. C., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Pinder, S. E., Ellis, I. O. and Robertson, J. F. R. 2001. Change in expression of ER, bcl-2 and MIB1 on primary tamoxifen and relation to response in ER positive breast cancer. Breast Cancer Research and Treatment 65 (2) , pp. 135-144. 10.1023/A:1006469627067

Yip, S. S., Crew, A. J., Gee, Julia Margaret Wendy

, Hui, R., Blamey, R. W., Robertson, J. F. R., Nicholson, Robert Ian, Sutherland, R. L. and Daly, R. J. 2000. Up-regulation of the protein tyrosine phosphatase SHP-1 in human breast cancer and correlation with GRB2 expression. International Journal of Cancer 88 (3) , pp. 363-368. 10.1002/1097-0215(20001101)88:3<363::AID-IJC7>3.0.CO;2-4

Madden, Tracie-Ann

, Barrow, Denise, McClelland, Richard Andrew, Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 2000. Modulation of oestrogen action by receptor gene inhibition. European Journal of Cancer 36 (S4) , pp. 34-35. 10.1016/S0959-8049(00)00216-1

Kenny, F. S., Pinder, S. E., Ellis, I. O., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Bryce, R. P. and Robertson, J. F. R. 2000. Gamma linolenic acid with tamoxifen as primary therapy tn breast cancer. International Journal of Cancer 85 (5) , pp. 643-648. 10.1002/(SICI)1097-0215(20000301)85:5<643::AID-IJC8>3.0.CO;2-Z

Knowlden, Janice Mary, Gee, Julia Margaret Wendy

, Robertson, J. F. R., Ellis, I. O. and Nicholson, Robert Ian 2000. A possible divergent role for the oestrogen receptor alpha and beta subtypes in clinical breast cancer. International Journal of Cancer 89 (2) , pp. 209-212. 10.1002/(SICI)1097-0215(20000320)89:2<209::AID-IJC17>3.0.CO;2-6

Gee, Julia Margaret Wendy

, Barroso, A. F., Ellis, I. O., Robertson, J. F. R. and Nicholson, Robert Ian 2000. Biological and clinical associations of c-jun activation in human breast cancer. International Journal of Cancer 89 (2) , pp. 177-186. 10.1002/(SICI)1097-0215(20000320)89:2<177::AID-IJC13>3.0.CO;2-0

Nicholson, Robert Ian and Gee, Julia Margaret Wendy

2000. Oestrogen and growth factor cross-talk and endocrine insensitivity and acquired resistance in breast cancer. British Journal of Cancer 82 (3) , pp. 501-513. 10.1054/bjoc.1999.0954

Gee, Julia Margaret Wendy

, Robertson, J. F. R., Ellis, I. O. and Nicholson, Robert Ian 2000. Abstract P13: Impact of activation of MAP kinase family members on endocrine response and survival in clinical breast cancer [Abstract]. European Journal of Cancer 36 (S4) , p. 105. 10.1016/S0959-8049(00)00259-8

Gee, Julia Margaret Wendy

, Robertson, J. F. R., Ellis, I. O., Nicholson, Robert Ian and Hurst, H. C. 1999. Immunohistochemical analysis reveals a tumour suppressor-like role for the transcription factor AP-2 in invasive breast cancer. Journal of Pathology 189 (4) , pp. 514-520. 10.1002/(SICI)1096-9896(199912)189:4<514::AID-PATH463>3.0.CO;2-9

Seery, Liam T., Knowlden, Janice Mary, Gee, Julia Margaret Wendy

, Robertson, J. F. R., Kenny, F. S., Ellis, I. O. and Nicholson, Robert Ian 1999. [Corrigendum] BRCA1 expression levels predict distant metastasis of sporadic breast cancer (vol 84, pg 258, 1999). International Journal of Cancer 84 (5) , p. 544. 10.1002/(SICI)1097-0215(19991022)84:5<544::AID-IJC18>3.0.CO;2-9

Nicholson, Robert Ian, McClelland, Richard Andrew, Robertson, J. F. R. and Gee, Julia Margeret Wendy

1999. Involvement of steroid hormone and growth factor cross-talk in endocrine response in breast cancer. Endocrine-Related Cancer 6 (3) , pp. 373-387. 10.1677/erc.0.0060373

Kenny, F. S., Hui, R., Musgrove, E. A., Gee, Julia Margaret Wendy

, Blamey, R. W., Nicholson, Robert Ian, Sutherland, R. L. and Robertson, J. F. R. 1999. Overexpression of cyclin D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer. Clinical Cancer Research 5 (8) , pp. 2069-2076.

McClelland, Richard Andrew, Gee, Julia Margaret Wendy

, O'Sullivan, Louise A., Barnes, D. M., Robertson, J. F. R., Ellis, I. O. and Nicholson, Robert Ian 1999. p21(WAF1) expression and endocrine response in breast cancer. Journal of Pathology 188 (2) , pp. 126-132. 10.1002/(SICI)1096-9896(199906)188:2<126::AID-PATH340>3.0.CO;2-O

Seery, Liam T., Knowlden, Janice Mary, Gee, Julia Margaret Wendy

, Robertson, J. F. R., Kenny, F. S., Ellis, I. O. and Nicholson, Robert Ian 1999. BRCA1 expression levels predict distant metastasis of sporadic breast cancers. International Journal of Cancer 84 (3) , pp. 258-262. 10.1002/(SICI)1097-0215(19990621)84:3<258::AID-IJC10>3.0.CO;2-H

Davies, E. L., Gee, Julia Margaret Wendy

, Cochrane, Richard A., Jiang, Wen Guo

, Sharma, A. K., Nicholson, Robert Ian and Mansel, Robert Edward

1999. The immunohistochemical expression of desmoplakin and its role in vivo in the progression and metastasis of breast cancer. European Journal of Cancer 35 (6) , pp. 902-907. 10.1016/S0959-8049(99)00031-3

Gee, Julia Margaret Wendy

, Willsher, P. C., Kenny, F. S., Robertson, J. F. R., Pinder, S. E., Ellis, I. O. and Nicholson, Robert Ian 1999. Endocrine response and resistance in breast cancer: A role for the transcription factor Fos. International Journal of Cancer 84 (1) , pp. 54-61. 10.1002/(SICI)1097-0215(19990219)84:1<54::AID-IJC11>3.0.CO;2-X

Knowlden, Janice Mary, Gee, Julia Margaret Wendy

, Seery, L. T., Farrow, Lynne, Gullick, W. J., Ellis, I. O., Blamey, R. W., Robertson, J. F. R. and Nicholson, Robert Ian 1998. C-erbB3 and c-erbB4 expression is a feature of the endocrine responsive phenotype in clinical breast cancer. Oncogene 17 (15) , pp. 1949-1957.

Kenny, F. S., Willsher, P. C., Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Ellis, I. O. and Robertson, J. F. R. 1998. Change in expression of ER and BCL-2 predict for quality and duration of response in endocrine sensitive breast cancer [Abstract]. European Journal of Cancer 34 (S5) , S82. 10.1016/S0959-8049(98)80345-6

Willsher, P. C., Pinder, S. E., Gee, Julia Margaret Wendy

, Ellis, I. O., Chan, S. Y., Nicholson, Robert Ian, Blamey, R. W. and Robertson, J. F. R. 1998. c-erbB2 expression predicts response to preoperative chemotherapy for locally advanced breast cancer. Anticancer Research 18 (5B) , pp. 3695-3698.

Davies, E. L., Gee, Julia Margaret Wendy

, Cochrane, R. A., Nicholson, Robert Ian, Sharma, A. K., Jiang, Wen Guo

and Mansel, R. E. 1998. The expression of desmoglein-2 in primary breast cancer and its relation to a series of prognostic markers [Abstract]. British Journal of Cancer 78 (2) , p. 149. 10.1038/bjc.1998.457

McClelland, Richard Andrew, Manning, D. L., Gee, Julia Margaret Wendy

, Willsher, P., Robertson, J. F. R., Ellis, I. O., Blamey, R. W. and Nicholson, Robert Ian 1998. Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy. British Journal of Cancer 77 (10) , pp. 1653-1656. 10.1038/bjc.1998.457

Knowlden, Janice Mary, Gee, Julia Margaret Wendy

, Bryant, S., McClelland, Richard Andrew, Manning, D. L., Mansel, R., Ellis, I. O., Blamey, R. W., Robertson, J. F. R. and Nicholson, Robert Ian 1997. Use of reverse transcription-polymerase chain reaction methodology to detect estrogen-regulated gene expression in small breast cancer specimens. Clinical Cancer Research 3 (11) , pp. 2165-2172.

Dewhurst, L. O., Gee, Julia Margaret Wendy

, Rennie, I. G. and MacNeil, S. 1997. Tamoxifen, 17 beta-oestradiol and the calmodulin antagonist J8 inhibit human melanoma cell invasion through fibronectin. British Journal of Cancer 75 (6) , pp. 860-868. 10.1038/bjc.1997.153

Jones, Helen E., Eaton, C. L., Barrow, Denise, Dutkowski, Carol Mary, Gee, Julia Margaret Wendy

and Griffiths, K. 1997. Comparative studies of the mitogenic effects of epidermal growth factor and transforming growth factor-alpha and the expression of various growth factors in neoplastic and non-neoplastic prostatic cell lines. Prostate 30 (4) , pp. 219-231. 10.1002/(SICI)1097-0045(19970301)30:4<219::AID-PROS1>3.0.CO;2-G

Nicholson, Robert Ian, Gee, Julia Margaret Wendy

, Harper, Maureen Elaine, Ellis, I. O., Willsher, P. and Robertson, J. F. R. 1997. erbB signalling in clinical breast cancer: relationship to endocrine sensitivity. Endocrine-Related Cancer 4 (3) , pp. 297-305. 10.1677/erc.0.0040297

Sharma, A. K., Grimshaw, D., Horgan, K., Neades, G. T., Gee, Julia Margaret Wendy

, Douglas-Jones, Anthony Gordon, Mansel, R. E. and Nicholson, Robert Ian 1996. Analysis of the genes for oestrogen and epidermal growth factor receptors in human breast cancer. The Breast 5 (5) , pp. 344-350. 10.1016/S0960-9776(96)90002-8

Sharma, A. K., Grimshaw, D., Horgan, K., Mansel, R. E., Gee, Julia Margaret Wendy

and Nicholson, Robert Ian 1996. Mechanisms responsible for oestrogen receptor expression in primary human breast cancer. The Breast 5 (4) , pp. 237-243. 10.1016/S0960-9776(96)90017-X

Nicholson, Robert Ian, Francis, A. B., Kyme, Susan R. and Gee, Julia Margaret Wendy

1996. Properties and mode of action of pure antioestrogens in breast cancer in vitro. The Breast 5 (3) , pp. 175-180. 10.1016/S0960-9776(96)90089-2

McClelland, Richard Andrew, Gee, Julia Margaret Wendy

, Francis, A. B., Robertson, J. F. R., Blamey, R. W., Wakeling, A. E. and Nicholson, Robert Ian 1996. Short-term effects of pure anti-oestrogen ICI 182780 treatment on oestrogen receptor, epidermal growth factor receptor and transforming growth factor-alpha protein expression in human breast cancer. European Journal of Cancer 32 (3) , pp. 413-416. 10.1016/0959-8049(95)00517-X

Nicholson, Robert Ian, Gee, Julia Margaret Wendy

, Bryant, S., Francis, A. B., McClelland, Richard Andrew, Knowlden, Janice Mary, Wakeling, A. E. and Osborne, C. K. 1996. Pure antiestrogens - The most important advance in the endocrine therapy of breast cancer since 1896? Castagnetta, L., Nenci, I. and Bradlow, H. L., eds. Basis for Cancer Management, Annals of the New York Academy of Sciences, vol. 784. New York: New York Academy of Sciences, pp. 325-335. (10.1111/j.1749-6632.1996.tb16247.x)

McClelland, Richard Andrew, Manning, D. L., Gee, Julia Margaret Wendy

, Anderson, E., Clarke, R., Howell, A., Dowsett, M., Robertson, J. E., Blamey, R. W., Wakeling, A. E. and Nicholson, Robert Ian 1996. Effects of short-term antiestrogen treatment of primary breast cancer on estrogen receptor mRNA and protein expression and on estrogen-regulated genes. Breast Cancer Research and Treatment 41 (1) , pp. 31-41. 10.1007/BF01807034

Gupta, Sanjeev K., Pace, Doreen, Gee, Julia Margaret Wendy

, Douglas-Jones, Anthony Gordon, Morgan, J. M. and Mansel, R. E. 1996. Epithelial markers in lobular carcinoma [Abstract]. Journal of Pathology 179 (S1) , 16A. 10.1002/path.1996.1711790502

Gee, Julia Margaret Wendy

, Douglas-Jones, Anthony Gordon, Hepburn, P., Sharma, A. K., McClelland, Richard Andrew, Ellis, I. O. and Nicholson, Robert Ian 1995. A cautionary note regarding the application of Ki-67 antibodies to paraffin-embedded breast cancers. Journal of Pathology 177 (3) , pp. 285-293. 10.1002/path.1711770311

Nicholson, Robert Ian, McClelland, Richard Andrew and Gee, Julia Margaret Wendy

1995. Steroid hormone receptors and their clinical significance in cancer. Journal of Clinical Pathology 48 (10) , pp. 890-895. 10.1136/jcp.48.10.890

Gee, Julia Margaret Wendy

, Ellis, I. O., Robertson, J. F. R., Willsher, P., McClelland, Richard Andrew, Hewitt, K. N., Blamey, R. W. and Nicholson, Robert Ian 1995. Immunocytochemical localization of fos protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy. International Journal of Cancer 64 (4) , pp. 269-273. 10.1002/ijc.2910640410

Robertson, J. F. R., Gee, Julia Margaret Wendy

, McClelland, Richard Andrew, Ellis, I. O., Willsher, P., Blamey, R. W. and Nicholson, Robert Ian 1995. BCL2 Expression In Breast-Cancer - Identification Of Patients Who Should Not Receive Endocrine Therapy [Abstract]. British Journal of Surgery 82 (5) , p. 698. 10.1002/bjs.1800820540

Hepburn, P. J., Glynne-Jones, E., Goddard, Lindy, Gee, Julia Margaret Wendy

and Harper, Maureen Elaine 1995. Cell proliferation in prostatic carcinoma: comparative analysis of Ki-67, MIB-1 and PCNA. Histochemical Journal 27 (3) , pp. 196-203. 10.1007/BF00177586

Manning, D. L., McClelland, Richard Andrew, Knowlden, Janice Mary, Bryant, S., Gee, Julia Margaret Wendy

, Green, C. D., Robertson, J. F. R., Blamey, R. W., Sutherland, R. L., Ormandy, C. J. and Nicholson, Robert Ian 1995. Differential expression of estrogen-regulated genes in breast-cancer. Acta Oncologica 34 (5) , pp. 641-646.

Nicholson, Robert Ian, Gee, Julia Margaret Wendy

, Francis, A. B., Manning, D. L., Wakeling, A. E. and Katzenellenbogen, B. S. 1995. Observations arising from the use of pure antioestrogens on oestrogen-responsive (MCF-7) and oestrogen growth-independent (K3) human breast cancer cells. Endocrine-Related Cancer 2 (1) , pp. 115-121. 10.1677/erc.0.0020115

Nicholson, Robert Ian, Gee, Julia Margaret Wendy

, Manning, D. L., Wakeling, A. E., Montano, M. M. and Katzenellenbogen, B. S. 1995. Responses to Pure Antiestrogens (ICI 164384, ICI182780) in Estrogen-Sensitive and-Resistant Experimental and Clinical Breast Cancer. Philibert, D., Roy, A. K., Teutsch, G. and Henderson, D., eds. Steroid Receptors and Antihormones, Annals of the New York Academy of Sciences, vol. 761. New York: New York Academy of Sciences, pp. 148-163. (10.1111/j.1749-6632.1995.tb31376.x)

Gee, Julia Margaret Wendy

, Robertson, J. F. R., Ellis, I. O., Willsher, P., McClelland, Richard Andrew, Hoyle, H. B., Kyme, S. R., Finlay, Pauline, Blamey, R. W. and Nicholson, Robert Ian 1994. Immunocytochemical localization of BCL-2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy. International Journal of Cancer 59 (5) , pp. 619-628. 10.1002/ijc.2910590508

Nicholson, Robert Ian, McClelland, Richard Andrew, Gee, Julia Margaret Wendy

, Manning, D. L., Cannon, P., Robertson, J. F. R., Ellis, I. O. and Blamey, R. W. 1994. Transforming growth factor-α and endocrine sensitivity in breast cancer. Cancer Research 54 (7) , pp. 1684-1689.

Nicholson, Robert Ian, McClelland, Richard Andrew, Gee, Julia Margaret Wendy

, Manning, David L., Cannon, P., Robertson, J. F. R., Ellis, I. O. and Blamey, R. W. 1994. Epidermal growth factor receptor expression in breast cancer: Association with response to endocrine therapy. Breast Cancer Research and Treatment 29 (1) , pp. 117-125. 10.1007/BF00666187

Manning, D. L., Robertson, J. F. R., Ellis, I. O., Elston, C. W., McClelland, Richard Andrew, Gee, Julia Margaret Wendy

, Jones, R. J., Green, C. D., Cannon, P., Blamey, R. W. and Nicholson, Robert Ian 1994. Oestrogen-regulated genes in breast cancer: Association of pLIV1 with lymph node involvement. European Journal of Cancer 30 (5) , pp. 675-678. 10.1016/0959-8049(94)90543-6

Nicholson, Robert Ian, Francis, A. B., McClelland, Richard Andrew, Manning, D. L. and Gee, Julia Margaret Wendy

1994. Pure anti-oestrogens (ICI 164384 and ICI 182780) and breast cancer: is the attainment of complete oestrogen withdrawal worthwhile? Endocrine-Related Cancer 1 (4) , pp. 5-17. 10.1677/erc.0.0010005

Ghandour, F. A., Attanoos, Richard L., Nahar, K., Gee, Julia Margaret Wendy

, Bigrigg, A. and Ismail, Sezgin M. 1994. Immunocytochemical localization of oestrogen and progesterone receptors in primary adenocarcinoma of the cervix. Histopathology 24 (1) , pp. 49-55. 10.1111/j.1365-2559.1994.tb01270.x

Nicholson, Robert Ian, Gee, Julia Margaret Wendy

, Eaton, C. L., Manning, D. L., Mansel, R. E., Sharma, A. K., Douglas-Jones, Anthony Gordon, Price-Thomas, M., Howell, A., Defriend, D. J., Bundred, N. J., Anderson, E., Robertson, J. F. R., Blamey, R. W., Dowsett, M., Baum, M., Walton, P. and Wakeling, A. E. 1994. Pure antioestrogens in breast cancer - experimental and clinical observations. Presented at: Sex Hormones and Antihormones in Endocrine Dependent Pathology: Basic and Clinical Aspects: International Symposium, Milano, Italy, 10-14 April 1994. Published in: Motta, M. and Serio, M. eds. Sex Hormones and Antihormones in Endocrine Dependent Pathology: Basic and Clinical Aspects: Proceedings of an International Symposium, Milano, Italy, 10-14 April 1994. SEX HORMONES AND ANTIHORMONES IN ENDOCRINE DEPENDENT PATHOLOGY: BASIC AND CLINICAL ASPECTS. International Congress Series (1064) Amsterdam: Elsevier Science, pp. 347-360.

Schmid, K. W., Ellis, I. O., Gee, Julia Margaret Wendy

, Darke, Barbara M., Lees, W. E., Kay, John, Cryer, Anthony, Stark, J. M., Hittmair, A., Öfner, D., Dünser, M., Margreiter, R., Daxenbichler, G., Nicholson, Robert Ian, Bier, B., Böcker, W. and Jasani, Bharat 1993. Presence and possible significance of immunocytochemically demonstrable metallothionein over-expression in primary invasive ductal carcinoma of the breast. Virchovs Archiv 422 (2) , pp. 153-159. 10.1007/BF01607167

Manning, D. L., McClelland, Richard Andrew, Gee, Julia Margaret Wendy

, Chan, C. M. W., Green, C. D., Blamey, R. M. and Nicholson, Robert Ian 1993. The role of four oestrogen-responsive genes, pLIV1, pS2, pSYD3 and pSYD8, in predicting responsiveness to endocrine therapy in primary breast cancer. European Journal of Cancer 29 (10) , pp. 1462-1468. 10.1016/0959-8049(93)90021-7

Jasani, Bharat, Thomas, N. D., Navabi, H., Millar, David M., Newman, G. R., Gee, Julia Margaret Wendy

and Williams, E. D. 1992. Dinitrophenyl (DNP) hapten sandwich staining (DHSS) procedure: A 10 year review of its principle reagents and applications. Journal of Immunological Methods 150 (1-2) , pp. 193-198. 10.1016/0022-1759(92)90078-8

Gee, Julia Margaret Wendy

, Amselgruber, W. M., Jasani, Bharat and Nicholson, Robert Ian 1991. Use of the dinitrophenyl hapten sandwich staining procedure (DHSS) to localize estrogen receptors in paraffin-embedded tissues. Journal of Histochemistry & Cytochemistry 39 (12) , pp. 1659-1670. 10.1177/39.12.1719072

Nicholson, Robert Ian, Walker, Kate J., Bouzubar, N., Wills, R. J., Gee, Julia Margaret Wendy

, Rushmere, N. K. and Davies, P. 1990. Estrogen Deprivation in Breast Cancer: Clinical, Experimental, and Biological Aspects. Castagnetta, L., D'Aquino, S., Labrie, F. and Bradlow, H. L., eds. Steroid Formation, Degradation, and Action in Peripheral Tissues, Annals of the New York Academy of Sciences, vol. 595. New York: New York Academy of Sciences, pp. 316-327. (10.1111/j.1749-6632.1990.tb34305.x)

Gee, Julia Margaret Wendy

, Nicholson, Robert Ian, Jasani, Bharat, Newman, G. R. and Amselgruber, W. M. 1990. An immunocytochemical method for localization of estrogen receptors in rat tissues using a dinitrophenyl (DNP)-labeled rat monoclonal primary antibody. Journal of Histochemistry & Cytochemistry 38 (1) , pp. 69-78. 10.1177/38.1.1688451

Nicholson, Robert Ian, Gotting, K. E., Gee, Julia Margaret Wendy

and Walker, Kate J. 1988. Actions of oestrogens and antioestrogens on rat mammary gland development: Relevance to breast cancer prevention. Journal of Steroid Biochemistry 30 (1-6) , pp. 95-103. 10.1016/0022-4731(88)90081-7

This list was generated on Sun Dec 29 06:15:08 2024 GMT.