Astrocytes at the intersection of ageing, obesity, and neurodegeneration

Firth, Wyn ORCID: https://orcid.org/0000-0001-6531-2580, Pye, Katherine R. and Weightman Potter, Paul G. 2024. Astrocytes at the intersection of ageing, obesity, and neurodegeneration. Clinical Science 138 (8) , pp. 515-536. 10.1042/CS20230148

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Abstract

Once considered passive cells of the central nervous system (CNS), glia are now known to actively maintain the CNS parenchyma; in recent years, the evidence for glial functions in CNS physiology and pathophysiology has only grown. Astrocytes, a heterogeneous group of glial cells, play key roles in regulating the metabolic and inflammatory landscape of the CNS and have emerged as potential therapeutic targets for a variety of disorders. This review will outline astrocyte functions in the CNS in healthy ageing, obesity, and neurodegeneration, with a focus on the inflammatory responses and mitochondrial function, and will address therapeutic outlooks.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Optometry and Vision Sciences
Publisher:	Portland Press
ISSN:	0143-5221
Date of First Compliant Deposit:	5 November 2024
Last Modified:	05 Nov 2024 16:30
URI:	https://orca.cardiff.ac.uk/id/eprint/172743

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