Firth, Wyn  ORCID: https://orcid.org/0000-0001-6531-2580, Pye, Katherine R. and Weightman Potter, Paul G.
2024.
Astrocytes at the intersection of ageing, obesity, and neurodegeneration.
Clinical Science
138
(8)
, pp. 515-536.
10.1042/CS20230148
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Official URL: https://doi.org/10.1042/CS20230148
Abstract
Once considered passive cells of the central nervous system (CNS), glia are now known to actively maintain the CNS parenchyma; in recent years, the evidence for glial functions in CNS physiology and pathophysiology has only grown. Astrocytes, a heterogeneous group of glial cells, play key roles in regulating the metabolic and inflammatory landscape of the CNS and have emerged as potential therapeutic targets for a variety of disorders. This review will outline astrocyte functions in the CNS in healthy ageing, obesity, and neurodegeneration, with a focus on the inflammatory responses and mitochondrial function, and will address therapeutic outlooks.
| Item Type: | Article |
|---|---|
| Date Type: | Published Online |
| Status: | Published |
| Schools: | Schools > Optometry and Vision Sciences |
| Publisher: | Portland Press |
| ISSN: | 0143-5221 |
| Date of First Compliant Deposit: | 5 November 2024 |
| Last Modified: | 05 Nov 2024 16:30 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/172743 |
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