More and more pleiotropy within the IL ‐6 family of cytokines

Rose‐John, Stefan and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 2025. More and more pleiotropy within the IL ‐6 family of cytokines. The FEBS Journal 292 (3) , pp. 519-522. 10.1111/febs.17355

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Abstract

Historically, cytokines belonging to the gp130 family bind to specific ligand‐binding receptors that stimulate cell signaling through a receptor complex comprising gp130 or gp130 together with another structurally related signaling receptor. However, recent findings increasingly dispel these stereotypes and suggest that the receptor specificity of gp130‐activating cytokines is less strict than originally assumed. Weitz et al. now provide the latest example of this pleiotropy and report that human interleukin‐6 can bind and stimulate signaling via the interleukin‐11 receptor. Possible biological and therapeutic consequences of these findings are discussed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/
Publisher:	Wiley
ISSN:	1742-464X
Funders:	Deutsche Forschungsgemeinschaft, Deutsche Krebshilfe, Kidney Research UK, Versus Arthritis Grants, UK Research and Innovation, Wellcome Trust, UK Dementia Research Institute, National Health and Medical Research Council of Australia
Date of First Compliant Deposit:	19 December 2024
Date of Acceptance:	2 December 2024
Last Modified:	06 Feb 2025 15:02
URI:	https://orca.cardiff.ac.uk/id/eprint/174847

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