Genomics of schizophrenia, bipolar disorder and major depressive disorder.

Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862, Bray, Nicholas J. ORCID: https://orcid.org/0000-0002-4357-574X, Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053 and O'Donovan, Michael C. ORCID: https://orcid.org/0000-0001-7073-2379 2025. Genomics of schizophrenia, bipolar disorder and major depressive disorder. Nature Reviews Genetics 10.1038/s41576-025-00843-0 Item availability restricted.

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Abstract

Schizophrenia, bipolar disorder and major depressive disorder - which are the most common adult disorders requiring psychiatric care - contribute substantially to premature mortality and morbidity globally. Treatments for these disorders are suboptimal, there are no diagnostic pathologies or biomarkers and their pathophysiologies are poorly understood. Novel therapeutic and diagnostic approaches are thus badly needed. Given the high heritability of psychiatric disorders, psychiatry has potentially much to gain from the application of genomics to identify molecular risk mechanisms and to improve diagnosis. Recent large-scale, genome-wide association studies and sequencing studies, together with advances in functional genomics, have begun to illuminate the genetic architectures of schizophrenia, bipolar disorder and major depressive disorder and to identify potential biological mechanisms. Genomic findings also point to the aetiological relationships between different diagnoses and to the relationships between adult psychiatric disorders and childhood neurodevelopmental conditions. [Abstract copyright: © 2025. Springer Nature Limited.]

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Schools > Medicine
Publisher:	Nature Research
ISSN:	1471-0056
Date of First Compliant Deposit:	16 June 2025
Date of Acceptance:	10 April 2025
Last Modified:	16 Jun 2025 09:30
URI:	https://orca.cardiff.ac.uk/id/eprint/178898

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