Microbe-responsive human γδ T cells: The peculiar case of Staphylococcus aureus

Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348, Mata Forsberg, Manuel, McLaren, James ORCID: https://orcid.org/0000-0002-7021-5934 and Sverremark-Ekström, Eva 2025. Microbe-responsive human γδ T cells: The peculiar case of Staphylococcus aureus. Immunology & Cell Biology 10.1111/imcb.70060

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Abstract

Vγ9/Vδ2 T cells represent the largest γδ T-cell population in human blood and possess a unique responsiveness towards microbial organisms by sensing the metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP) in the context of the butyrophilin family members BTN2A1 and BTN3A1. Curiously, the bacterium Staphylococcus aureus does not produce HMB-PP but appears to be capable of inducing activation, cytokine expression and proliferation of Vγ9/Vδ2 T cells regardless, through a largely unknown mechanism. We here provide a comprehensive review of the existing literature around Vγ9/Vδ2 T-cell responses to S. aureus and discuss potential pathways, ligands and biological functions.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Schools > Medicine
Publisher:	Wiley
ISSN:	0818-9641
Date of First Compliant Deposit:	23 September 2025
Date of Acceptance:	12 September 2025
Last Modified:	23 Sep 2025 09:00
URI:	https://orca.cardiff.ac.uk/id/eprint/181162

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