| Eberl, Matthias  ORCID: https://orcid.org/0000-0002-9390-5348, Mata Forsberg, Manuel, McLaren, James  ORCID: https://orcid.org/0000-0002-7021-5934 and Sverremark-Ekström, Eva
      2025.
      
      Microbe-responsive human γδ T cells: The peculiar case of Staphylococcus aureus.
      Immunology & Cell Biology
      
      
      
      
      10.1111/imcb.70060   | 
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Abstract
Vγ9/Vδ2 T cells represent the largest γδ T-cell population in human blood and possess a unique responsiveness towards microbial organisms by sensing the metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP) in the context of the butyrophilin family members BTN2A1 and BTN3A1. Curiously, the bacterium Staphylococcus aureus does not produce HMB-PP but appears to be capable of inducing activation, cytokine expression and proliferation of Vγ9/Vδ2 T cells regardless, through a largely unknown mechanism. We here provide a comprehensive review of the existing literature around Vγ9/Vδ2 T-cell responses to S. aureus and discuss potential pathways, ligands and biological functions.
| Item Type: | Article | 
|---|---|
| Date Type: | Published Online | 
| Status: | In Press | 
| Schools: | Schools > Medicine | 
| Publisher: | Wiley | 
| ISSN: | 0818-9641 | 
| Date of First Compliant Deposit: | 23 September 2025 | 
| Date of Acceptance: | 12 September 2025 | 
| Last Modified: | 23 Sep 2025 09:00 | 
| URI: | https://orca.cardiff.ac.uk/id/eprint/181162 | 
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