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The synthesis of [18F]SynVesT-1 and [18F]SynVesT-2 from enantioenriched boronic esters

Qin, Marong, Mishra, Pawan ORCID: https://orcid.org/0000-0003-1141-3487, Hind, Jasmine, Fallis, Ian ORCID: https://orcid.org/0000-0001-7361-0182 and Tredwell, Matthew ORCID: https://orcid.org/0000-0002-4184-5611 2025. The synthesis of [18F]SynVesT-1 and [18F]SynVesT-2 from enantioenriched boronic esters. Chemical Communications 10.1039/D5CC05507E

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Abstract

Enantioenrcihed [18F]SynVesT-1 and [18F]SynVesT-2 are prepared from the corresponding enantioenriched arylboronic esters and [18F]fluoride mediated by (Py)4Cu(OTf)2. The 18F-reaction is optimised on an automated synthesiser to produce multi-GBq quantites of both radiotracers to support (pre)clinical imaging.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Schools > Chemistry
Publisher: Royal Society of Chemistry
ISSN: 1359-7345
Date of First Compliant Deposit: 14 October 2025
Date of Acceptance: 8 October 2025
Last Modified: 14 Oct 2025 09:46
URI: https://orca.cardiff.ac.uk/id/eprint/181605

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