Principles of the Ca2+ homeostatic/signalling system

Verkhratsky, Alexei and Petersen, Ole Holger ORCID: https://orcid.org/0000-0002-6998-0380 2010. Principles of the Ca2+ homeostatic/signalling system. Verkhratsky, Alexei and Petersen, Ole Holger, eds. Calcium Measurement Methods, Neuromethods, vol. 43. New York: Humana Press, pp. 1-11. (10.1007/978-1-60761-476-0_1)

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Abstract

Calcium ions are the most ubiquitous and pluripotent signalling molecules, which regulate a wide array of physiological and pathological reactions. The specific system, controlling cellular Ca2+ homeostasis appeared very early in the evolution, being initially survival system preventing Ca2+-mediated cell damage. Subsequently, the steep Ca2+ gradients maintained by Ca2+ homeostatic molecular cascades became the basis for Ca2+ signalling. This signalling system utilises Ca2+ channels and transporters localised in plasmalemma and intracellular membranes to create highly organised and compartmentalised cytosolic Ca2+ fluctuations occurring within the spatial and temporal domains. Changes in cytosolic Ca2+ concentrations regulate a multitude of Ca2+-dependent proteins, which serve as “Ca2+ sensors” and thus the effectors of Ca2+ signalling system.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Biosciences Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > Q Science (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Calcium ; Ca2+ homeostasis ; Ca2+ signalling ; Neurones ; Glia ; Nervous system
Additional Information:	pbk ISBN: 9781617796777
Publisher:	Humana Press
ISBN:	9781607614753
Related URLs:	Publisher
Last Modified:	10 Feb 2023 16:39
URI:	https://orca.cardiff.ac.uk/id/eprint/18283

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