Verkhratsky, Alexei and Petersen, Ole Holger  ORCID: https://orcid.org/0000-0002-6998-0380
2010.
Principles of the Ca2+ homeostatic/signalling system.
Verkhratsky, Alexei and Petersen, Ole Holger, eds.
Calcium Measurement Methods,
Neuromethods,
vol. 43.
New York:
Humana Press,
pp. 1-11.
(10.1007/978-1-60761-476-0_1)
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Abstract
Calcium ions are the most ubiquitous and pluripotent signalling molecules, which regulate a wide array of physiological and pathological reactions. The specific system, controlling cellular Ca2+ homeostasis appeared very early in the evolution, being initially survival system preventing Ca2+-mediated cell damage. Subsequently, the steep Ca2+ gradients maintained by Ca2+ homeostatic molecular cascades became the basis for Ca2+ signalling. This signalling system utilises Ca2+ channels and transporters localised in plasmalemma and intracellular membranes to create highly organised and compartmentalised cytosolic Ca2+ fluctuations occurring within the spatial and temporal domains. Changes in cytosolic Ca2+ concentrations regulate a multitude of Ca2+-dependent proteins, which serve as “Ca2+ sensors” and thus the effectors of Ca2+ signalling system.
| Item Type: | Book Section |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Biosciences Research Institutes & Centres > Systems Immunity Research Institute (SIURI) |
| Subjects: | Q Science > Q Science (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Uncontrolled Keywords: | Calcium ; Ca2+ homeostasis ; Ca2+ signalling ; Neurones ; Glia ; Nervous system |
| Additional Information: | pbk ISBN: 9781617796777 |
| Publisher: | Humana Press |
| ISBN: | 9781607614753 |
| Related URLs: | |
| Last Modified: | 10 Feb 2023 16:39 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/18283 |
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