Lack of involvement of alpha-synuclein in unconditioned anxiety in mice

Peña-Oliver, Yolanda, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Stephens, David 2010. Lack of involvement of alpha-synuclein in unconditioned anxiety in mice. Behavioural Brain Research 209 (2) , pp. 234-240. 10.1016/j.bbr.2010.01.049

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Abstract

Alpha-synuclein is implicated in the pathology of Parkinson disease (PD) and is involved in synaptic function, particularly in presynaptic events in dopamine (DA) synapses. Recently, a role for alpha-synuclein in reward and addiction, especially in alcoholism, has been reported. Since PD and alcohol dependence present a strong comorbidity with anxiety disorders, a role for alpha-synuclein in anxiety has been proposed. The aim of the present investigation was to study the involvement of alpha-synuclein in anxiety by testing alpha-synuclein knock out and wild type mice in three different emotionality tests: the open field, the elevated plus maze and the light–dark box. Alpha-synuclein knock out mice and wild type controls displayed consistently similar emotionality profiles in all the tests, suggesting a lack of involvement of alpha-synuclein in unconditioned anxiety in mice.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > Q Science (General)
Uncontrolled Keywords:	alpha-synuclein; anxiety; mice; open field; elevated plus maze; light–dark box
Publisher:	Elsevier
ISSN:	0166-4328
Last Modified:	19 Oct 2022 08:45
URI:	https://orca.cardiff.ac.uk/id/eprint/18939

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