Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder

Green, Elaine Karen, Grozeva, Detelina ORCID: https://orcid.org/0000-0003-3239-8415, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Hamshere, Marian Lindsay ORCID: https://orcid.org/0000-0002-8990-0958, Jones, Ian Richard ORCID: https://orcid.org/0000-0001-5821-5889, Jones, Lisa, Forty, Elizabeth, Caesar, Sian, Gordon-Smith, Katherine, Fraser, Christine, Russell, Elen, St Clair, David, Young, Allan H., Ferrier, Nicol, Farmer, Anne, McGuffin, Peter, Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 and Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610 2010. Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B (7) , pp. 1347-1349. 10.1002/ajmg.b.31108

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Abstract

We have previously reported evidence that variation at GABAA receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Systems Immunity Research Institute (SIURI) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	bipolar disorder; schizoaffective disorder; GABAA receptor; genetics
Publisher:	Wiley-Blackwell
ISSN:	1552-4841
Last Modified:	05 Oct 2024 13:56
URI:	https://orca.cardiff.ac.uk/id/eprint/22152

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