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Complement regulator factor H in multiple sclerosis

Ingram, Gillian, Hakobyan, Svetlana, Loveless, Samantha, Robertson, Neil and Morgan, Bryan Paul 2011. Complement regulator factor H in multiple sclerosis. Journal of Cellular Biochemistry 112 (10) , pp. 2653-2654. 10.1002/jcb.23204

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A recent proteomic study published in this journal demonstrated lower cerebrospinal fluid (CSF) expression of factor H (fH), an important complement regulator, along with two other complement proteins, in active multiple sclerosis (MS) patients. We have previously demonstrated raised serum fH levels in MS and here, an extended analysis, quantifying fH in CSF, demonstrates no change in fH levels in active disease, but significantly raised levels in progressive disease. These findings support our previous work showing raised serum fH in patients with progressive MS, and our results predict that CSF fH levels will be raised rather than reduced in active disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Multiple sclerosis; biomarker; complement; factor H
Publisher: John Wiley & Sons
ISSN: 0730-2312
Last Modified: 06 Feb 2020 21:20

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