To B or not to B - pathogenic and regulatory B cells in autoimmune diabetes

Wong, Florence Susan ORCID: https://orcid.org/0000-0002-2812-8845, Hu, Changyun, Xiang, Yufei and Wen, Li 2010. To B or not to B - pathogenic and regulatory B cells in autoimmune diabetes. Current Opinion in Immunology 22 (6) , pp. 723-731. 10.1016/j.coi.2010.10.002

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Abstract

B cells have a vitally important function to produce antibodies which are directly pathogenic in some autoimmune diseases. However, it is clear that a number of other B cell functions are also critical in the pathogenesis of organ-specific autoimmune diseases that were previously thought to be mainly T cell mediated. Therapeutic agents that target B cells and their functions may therefore be of considerable importance in these autoimmune diseases. In this review, we will focus on B cell characteristics and functions that contribute to type 1 diabetes (T1D) and discuss why anti-B cell treatment may be effective in T1D, a disease that was previously considered to be primarily T cell mediated.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RB Pathology
Publisher:	Elsevier
ISSN:	0952-7915
Last Modified:	19 Oct 2022 10:27
URI:	https://orca.cardiff.ac.uk/id/eprint/24410

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