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Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice

Xiao, Xiaoyan, Ma, Bin, Dong, Baojun, Zhao, Peng, Tai, Ningwen, Chen, Li, Wong, Florence Susan and Wen, Li 2009. Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice. Journal of Autoimmunity 32 (2) , pp. 85-93. 10.1016/j.jaut.2008.12.003

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This study was designed to examine immunopathology of diabetic nephropathy in non-obese diabetic (NOD) mice and to investigate the involvement of cellular and humoral immunity at various time points after diabetes onset. We found that the glomeruli of diabetic NOD mice were infiltrated with T and B cells, as well as CD11c+ dendritic cells, which had close contact with CD4+ and CD8+ T cells in the infiltrates. We also found that IgG deposits in the glomeruli of diabetic NOD mice were accompanied by the presence of complement C3. Moreover, the serum from diabetic mice contained autoantibodies directed towards components of the glomeruli and these antibodies were not present in non-diabetic NOD mice. The immune changes in the kidney occurred together with increasing kidney weight and urinary albumin excretion along with duration of diabetes. We provide evidence that infiltrating lymphocytes and anti-kidney autoantibodies may be involved in diabetic nephropathy in autoimmune diabetes in the NOD mouse. Understanding the role that the immune system plays in the pathogenesis of diabetic nephropathy could lead to identification of new strategies and/or additional therapeutic targets for prevention and treatment of diabetic nephropathy.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: non-obese diabetic mice, kidney, diabetic nephropathy, immune response
Publisher: Elsevier
ISSN: 0896-8411
Last Modified: 04 Jun 2017 03:45

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