Elevated plasma C4a levels in multiple sclerosis correlate with disease activity

Ingram, Gillian, Hakobyan, Svetlana, Robertson, Neil ORCID: https://orcid.org/0000-0002-5409-4909 and Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676 2010. Elevated plasma C4a levels in multiple sclerosis correlate with disease activity. Journal of Neuroimmunology 223 (1-2) , pp. 124-127. 10.1016/j.jneuroim.2010.03.014

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Abstract

Complement plays a pivotal role in the pathogenesis of multiple sclerosis. C4a, an activated fragment of complement component C4, has been linked to disease activity. We correlated plasma C4 and plasma and CSF C4a with clinical disease in a well-characterised cohort of patients and controls. Plasma C4 was non-significantly and CSF C4a was significantly elevated overall in patients compared to controls. Plasma C4a was raised only in acute relapse, decreasing over 2 months. Results demonstrate intrathecal and systemic activation of complement, reflected in changes in CSF and plasma C4a. The data support a role for complement activation in pathogenesis and suggest a systemic component to the disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	multiple sclerosis, complement, biomarker, relapse, C4a
Publisher:	Elsevier
ISSN:	0165-5728
Last Modified:	06 Nov 2022 13:04
URI:	https://orca.cardiff.ac.uk/id/eprint/26024

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