Kontis, Dimitris, Catani, Marco, Cuddy, Marion, Walshe, Muriel, Nosarti, Chiara, Jones, Derek K. ![]() |
Abstract
Very preterm birth (before 33 weeks gestation) is associated with the white matter damage, and a common sequel is reduced size and altered shape of the corpus callosum. We used diffusion tensor MRI to assess the corpus callosum in 63 very preterm and 45 term-born young adults. Indices of white matter microstructure [fractional anisotropy (FA) and mean diffusivity (MD)] were obtained for the genu, body and splenium. Very preterm females had higher MD in the genu than term-born females, indicating altered white matter microstructure. This was associated with lower performance IQ. The groups demonstrated different patterns of correlations between verbal learning and tract-specific FA and MD, consistent with the reorganization of white matter structure in adults born very preterm.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Cardiff University Brain Research Imaging Centre (CUBRIC) Psychology |
Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RG Gynecology and obstetrics |
Publisher: | Lippincott, Williams & Wilkins |
ISSN: | 0959-4965 |
Last Modified: | 20 Oct 2022 07:51 |
URI: | https://orca.cardiff.ac.uk/id/eprint/26706 |
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