Diffusion tensor MRI of the corpus callosum and cognitive function in adults born preterm

Kontis, Dimitris, Catani, Marco, Cuddy, Marion, Walshe, Muriel, Nosarti, Chiara, Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049, Wyatt, John, Rifkin, Larry, Murray, Robin and Allin, Matthew 2009. Diffusion tensor MRI of the corpus callosum and cognitive function in adults born preterm. NeuroReport 20 (4) , pp. 424-428. 10.1097/WNR.0b013e328325a8f9

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Abstract

Very preterm birth (before 33 weeks gestation) is associated with the white matter damage, and a common sequel is reduced size and altered shape of the corpus callosum. We used diffusion tensor MRI to assess the corpus callosum in 63 very preterm and 45 term-born young adults. Indices of white matter microstructure [fractional anisotropy (FA) and mean diffusivity (MD)] were obtained for the genu, body and splenium. Very preterm females had higher MD in the genu than term-born females, indicating altered white matter microstructure. This was associated with lower performance IQ. The groups demonstrated different patterns of correlations between verbal learning and tract-specific FA and MD, consistent with the reorganization of white matter structure in adults born very preterm.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Psychology
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RG Gynecology and obstetrics
Publisher:	Lippincott, Williams & Wilkins
ISSN:	0959-4965
Last Modified:	20 Oct 2022 07:51
URI:	https://orca.cardiff.ac.uk/id/eprint/26706

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