von Willebrand factor: evidence for variable clearance in vivo according to Y/C1584 phenotype and ABO blood group

Davies, James Anthony ORCID: https://orcid.org/0000-0003-3569-4500, Collins, Peter William ORCID: https://orcid.org/0000-0002-6410-1324, Hathaway, Lee Sarah and Bowen, Derrick John 2007. von Willebrand factor: evidence for variable clearance in vivo according to Y/C1584 phenotype and ABO blood group. Journal of Thrombosis and Haemostatis 6 (1) , pp. 97-103. 10.1111/j.1538-7836.2007.02809.x

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Abstract

Background: The plasma von Willebrand factor (VWF) level (VWF:Ag) is known to correlate with the VWFY/ C1584 variation and with ABO blood group. The ratio of the VWF propeptide (VWFpp) to VWF:Ag and the ratio of coagulation factor VIII (FVIII:C) to VWF:Ag have previously been used as indicators of VWF clearance and/or secretion. Objectives and methods: To investigate the mechanism underlying the relationship between VWF phenotype and VWF:Ag, the VWFpp/VWF:Ag ratio and FVIII:C/VWF:Ag ratio were determined for plasmas of phenotype Y/C1584, Y/ Y1584, blood group O and blood group A (n = 50 for each set). The blood group O plasmas comprised two sets of 25 with low and high mean VWF levels (Low-O and High-O), respectively; similarly for group A (Low-A and High- A). Results and conclusions: The VWFpp/VWF:Ag ratio was greater than 1 (unity) for Y/C1584 plasmas and significantly higher than for Y/Y1584 plasmas; however, the FVIII:C/ VWF:Ag ratiowas near unity for both and was not significantly different. These results are consistent with increased clearance for Y/C1584 VWF. Similarly, the VWFpp/VWF:Ag ratio and FVIII:C/VWF:Ag ratio in combination were consistent with increased VWF clearance in blood group O compared with blood group A, and in Low-O and Low-A, respectively, compared with High-O and High-A. The data indicate that in vivo C1584 and blood group O are associated with increased VWF clearance, and that clearance contributes to differing VWF level within a given blood group.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > R Medicine (General)
Uncontrolled Keywords:	ABO blood group; factor VIII; von Willebrand factor; von Willebrand factor propeptide; Y/C1584 polymorphism
Publisher:	Wiley-Blackwell
ISSN:	1538-7933
Last Modified:	04 Jan 2023 02:11
URI:	https://orca.cardiff.ac.uk/id/eprint/27393

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