Conditional CD8+ T cell escape during acute simian immunodeficiency virus infection

O'Connor, Shelby L., Becker, Ericka A., Weinfurter, Jason T., Chin, Emily N., Budde, Melisa L., Gostick, Emma, Correll, Michael, Gleicher, Michael, Hughes, Austin L., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Friedrich, Thomas C. and O'Connor, David H. 2011. Conditional CD8+ T cell escape during acute simian immunodeficiency virus infection. Journal of Virology 86 (1) , pp. 605-609. 10.1128/JVI.05511-11

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Abstract

immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) infection. We used pyrosequencing to examine variation within three SIV-derived epitopes (Gag386-394GW9, Nef103-111RM9, and Rev59-68SP10) targeted by immunodominant CD8+ T cell responses in acutely infected Mauritian cynomolgus macaques. In animals recognizing all three epitopes, variation within Rev59-68SP10 was associated with delayed accumulation of variants in Gag386-394GW9 but had no effect on variation within Nef103-111RM9. This demonstrates that the entire T cell repertoire, rather than a single T cell population, influences the timing of immune escape, thereby providing the first example of conditional CD8+ T cell escape in HIV/SIV infection.

Item Type:	Article
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QR Microbiology
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/0022-538X/ (accessed 25/02/2014)
Publisher:	American Society for Microbiology
ISSN:	0022-538X
Date of First Compliant Deposit:	30 March 2016
Last Modified:	11 Oct 2023 21:38
URI:	https://orca.cardiff.ac.uk/id/eprint/27556

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