Browse by Current Cardiff authors

, Eberl, Matthias

, Study, Swiss Pediatric Sepsis, Agyeman, Philipp K.A., Schlapbach, Luregn and Vermijlen, David 2024. Sepsis shapes the human γδ TCR repertoire in an age- and pathogen-dependent manner. European Journal of Immunology 54 (10) , 2451190. 10.1002/eji.202451190

White, Eoghann, Papagno, Laura, Samri, Assia, Sugata, Kenji, Hejblum, Boris, Henry, Amy R., Rogan, Daniel C., Darko, Samuel, Recordon-Pinson, Patricia, Dudoit, Yasmine, Llewellyn-Lacey, Sian, Chakrabarti, Lisa A., Buseyne, Florence, Migueles, Stephen A., Price, David A.

, Andreola, Marie-Aline, Satou, Yorifumi, Thiebaut, Rodolphe, Katlama, Christine, Autran, Brigitte, Douek, Daniel C. and Appay, Victor 2024. Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1. Nature Immunology 25 (9) , 1555–1564. 10.1038/s41590-024-01931-9
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Dallan, Beatrice, Proietto, Davide, De Laurentis, Martina, Gallerani, Eleonora, Martino, Mara, Ghisellini, Sara, Zurlo, Amedeo, Volpato, Stefano, Govoni, Benedetta, Borghesi, Michela, Albanese, Valentina, Appay, Victor, Bonnini, Stefano, Llewellyn-Lacey, Sian, Pacifico, Salvatore, Grumiro, Laura, Brandolini, Martina, Semprini, Simona, Sambri, Vittorio, Ladell, Kristin

, Parry, Helen M., Moss, Paul A. H., Price, David A.

, Barbieri, Elena, Bernardi, Tatiana, Boni, Michela, Dall?Olio, Linda, De Laurentis, Martina, Fiorini, Caterina, Fiorini, Michele, Govoni, Maurizio, Neri, Margherita, Palma, Fabio, Romagnoni, Franco, Caputo, Antonella, Gavioli, Riccardo and Nicoli, Francesco 2024. Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19. Nature Aging 4 (8) , 1121–1136. 10.1038/s43587-024-00644-w
Item availability restricted.

Heim, Kathrin, Saga, Sagar, Sogukpinar, Özlem, Llewellyn-Lacey, Sian, Price, David A.

, Emmerich, Florian, Kraft, Anke R. M., Cornberg, Markus, Kielbassa, Sophie, Knolle, Percy, Wohlleber, Dirk, Bengsch, Bertram, Boettler, Tobias, Neumann-Haefelin, Christoph, Thimme, Robert and Hofmann, Maike 2024. Attenuated effector T cells are linked to control of chronic HBV infection. Nature Immunology 25 (9) , pp. 1650-1662. 10.1038/s41590-024-01928-4

Simpson, Jennifer, Starke, Carly E., Ortiz, Alexandra M., Ransier, Amy, Darko, Sam, Llewellyn-Lacey, Sian, Fennessey, Christine M., Keele, Brandon F., Douek, Daniel C., Price, David A.

and Brenchley, Jason M. 2024. Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV. JCI Insight 9 (14) 10.1172/jci.insight.174168

Baillie, Kirsten, Davies, Helen E., Keat, Samuel B. K., Ladell, Kristin

, Miners, Kelly L., Jones, Samantha A., Mellou, Ermioni, Toonen, Erik J. M., Price, David A.

, Morgan, B. Paul

and Zelek, Wioleta M. 2024. Complement dysregulation is a prevalent and therapeutically amenable feature of long COVID. Med 5 (3) , pp. 239-253. 10.1016/j.medj.2024.01.011

Cabral-Piccin, Mariela P., Briceño, Olivia, Papagno, Laura, Liouville, Benjamin, White, Eoghann, Perdomo-Celis, Federico, Autaa, Gaëlle, Volant, Stevenn, Llewellyn-Lacey, Sian, Fromentin, Rémi, Chomont, Nicolas, Price, David A.

, Sáez-Cirión, Asier, Lambotte, Olivier, Katlama, Christine and Appay, Victor 2024. CD8+ T cell priming is quantitatively but not qualitatively impaired in people with HIV-1 on antiretroviral therapy. AIDS 38 (2) , pp. 161-166. 10.1097/QAD.0000000000003746

Cai, Curtis, Gao, Yu, Adamo, Sarah, Rivera-Ballesteros, Olga, Hansson, Lotta, Österborg, Anders, Bergman, Peter, Sandberg, Johan K., Ljunggren, Hans-Gustaf, Björkström, Niklas K., Strålin, Kristoffer, Llewellyn-Lacey, Sian, Price, David A.

, Qin, Chuan, Grifoni, Alba, Weiskopf, Daniela, Wherry, E. John, Sette, Alessandro, Aleman, Soo and Buggert, Marcus 2023. SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19. Science Immunology 8 (90) 10.1126/sciimmunol.adh0687

Winkler, Frances, Hipp, Anna V., Ramirez, Carlos, Martin, Bianca, Villa, Matteo, Neuwirt, Emilia, Gorka, Oliver, Aerssens, Jeroen, Johansson, Susanne E., Rana, Nisha, Llewellyn-Lacey, Sian, Price, David A.

, Panning, Marcus, Groß, Olaf, Pearce, Erika L., Hermann, Carl M., Schumann, Kathrin, Hannibal, Luciana, Neumann-Haefelin, Christoph, Boettler, Tobias, Knolle, Percy, Hofmann, Maike, Wohlleber, Dirk, Thimme, Robert and Bengsch, Bertram 2023. Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8 + T cells. Gut 72 (10) , pp. 1971-1984. 10.1136/gutjnl-2022-328734

Roger, Laureline, Miners, Kelly L., Leonard, Louise, Grimstead, Julia W., Price, David A.

, Baird, Duncan M.

and Ladell, Kristin

2023. T cell memory revisited using single telomere length analysis. Frontiers in Immunology 14 , 1100535. 10.3389/fimmu.2023.1100535

Knezevic, Lea, Wachsmann, Tassilo L.A., Francis, Ore, Dockree, Tamsin, Bridgeman, John S., Wouters, Anne, de Wet, Ben, Cole, David K., Clement, Mathew

, McLaren, James E., Gostick, Emma, Ladell, Kristin, Llewellyn-Lacey, Sian, Price, David A.

, van den Berg, Hugo A., Tabi, Zsuzsanna, Sessions, Richard B., Heemskerk, Mirjam H.M. and Wooldridge, Linda 2023. High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs. Journal of Biological Chemistry 299 (8) , 104981. 10.1016/j.jbc.2023.104981

Rubina, Anzelika, Patel, Mihil, Nightingale, Katie, Potts, Martin, Fielding, Ceri A.

, Kollnberger, Simon, Lau, Betty, Ladell, Kristin

, Miners, Kelly L., Nichols, Jenna, Nobre, Luis, Roberts, Dawn, Trinca, Terrence M., Twohig, Jason P., Vlahava, Virginia-Maria, Davison, Andrew J., Price, David A.

, Tomasec, Peter, Wilkinson, Gavin W. G., Weekes, Michael P., Stanton, Richard J.

and Wang, Eddie C. Y.

2023. ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways. Proceedings of the National Academy of Sciences 120 (33) , e2303155120. 10.1073/pnas.2303155120

Buggert, Marcus, Price, David A.

, Mackay, Laura K. and Betts, Michael R. 2023. Human circulating and tissue-resident memory CD8+ T cells. Nature Immunology 24 (7) , pp. 1076-1086. 10.1038/s41590-023-01538-6

Clement, Mathew

, Miners, Kelly L, Marsden, Morgan, Chapman, Lucy, Cardus Figueras, Anna, Scott, Jake, Andrews, Robert, Clare, Simon, Kriukova, Valeriia V, Lupyr, Ksenia R, Britanova, Olga V, Withers, David R, Jones, Simon A

, Chudakov, Dmitriy M, Price, David A

and Humphreys, Ian R

2023. Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1. eLife 12 , e79165. 10.7554/eLife.79165

Chen, Yi-Ling, Ng, Jessica Soo Weei, Ottakandathil Babu, Rosana, Woo, Jeongmin, Nahler, Janina, Hardman, Clare S., Kurupati, Prathiba, Nussbaum, Lea, Gao, Fei, Dong, Tao, Ladell, Kristin

, Duncan, David A., Johnson, David, Gileadi, Uzi, Koohy, Hashem and Ogg, Graham S. 2023. Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation. Science Immunology 8 (84) , eadd9232. 10.1126/sciimmunol.add9232

Adamo, Sarah, Gao, Yu, Sekine, Takuya, Mily, Akhirunnesa, Wu, Jinghua, Storgärd, Elisabet, Westergren, Victor, Filén, Finn, Treutiger, Carl-Johan, Sandberg, Johan K., Sällberg, Matti, Bergman, Peter, Llewellyn-Lacey, Sian, Ljunggren, Hans-Gustaf, Price, David A.

, Ekström, Anna-Mia, Sette, Alessandro, Grifoni, Alba and Buggert, Marcus 2023. Memory profiles distinguish cross-reactive and virus-specific T cell immunity to mpox. Cell Host & Microbe 31 (6) , pp. 928-936. 10.1016/j.chom.2023.04.015

Eser, Tabea M., Baranov, Olga, Huth, Manuel, Ahmed, Mohammed I. M., Deák, Flora, Held, Kathrin, Lin, Luming, Pekayvaz, Kami, Leunig, Alexander, Nicolai, Leo, Pollakis, Georgios, Buggert, Marcus, Price, David A.

, Rubio-Acero, Raquel, Reich, Jakob, Falk, Philine, Markgraf, Alissa, Puchinger, Kerstin, Castelletti, Noemi, Olbrich, Laura, Vanshylla, Kanika, Klein, Florian, Wieser, Andreas, Hasenauer, Jan, Kroidl, Inge, Hoelscher, Michael and Geldmacher, Christof 2023. Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion. Nature Communications 14 (1) , 2952. 10.1038/s41467-023-38020-8

Fahad, Ahmed S., Chung, Cheng Yu, López Acevedo, Sheila N., Boyle, Nicoleen, Madan, Bharat, Gutiérrez-González, Matías F., Matus-Nicodemos, Rodrigo, Laflin, Amy D., Ladi, Rukmini R., Zhou, John, Wolfe, Jacy, Llewellyn-Lacey, Sian, Koup, Richard A., Douek, Daniel C., Balfour, Henry H., Price, David A.

and DeKosky, Brandon J. 2023. Cell activation-based screening of natively paired human T cell receptor repertoires. Scientific Reports 13 , 8011. 10.1038/s41598-023-31858-4

Ciacchi, Lisa, van de Garde, Martijn D.B., Ladell, Kristin

, Farenc, Carine, Poelen, Martien C.M., Miners, Kelly L., Llerena, Carmen, Reid, Hugh H., Petersen, Jan, Price, David A.

and van Els, Cécile A.C.M. 2023. CD4+ T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity. Immunity 56 (5) , pp. 1082-1097. 10.1016/j.immuni.2023.03.020

Cabral-Piccin, Mariela P., Papagno, Laura, Lahaye, Xavier, Perdomo-Celis, Federico, Volant, Stevenn, White, Eoghann, Monceaux, Valérie, Llewellyn-Lacey, Sian, Fromentin, Rémi, Price, David A.

, Chomont, Nicolas, Manel, Nicolas, Saez-Cirion, Asier and Appay, Victor 2023. Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection. EBioMedicine 91 , 104557. 10.1016/j.ebiom.2023.104557

Shepherd, Freya R., Davies, Kate

, Miners, Kelly L., Llewellyn-Lacey, Sian, Kollnberger, Simon, Redman, James E.

, Grant, Melissa M., Ladell, Kristin

and McLaren, James E.

2023. The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells. Communications Biology 6 , 78. 10.1038/s42003-023-04420-1

Proietto, Davide, Dallan, Beatrice, Gallerani, Eleonora, Albanese, Valentina, Llewellyn-Lacey, Sian, Price, David A.

, Appay, Victor, Pacifico, Salvatore, Caputo, Antonella, Nicoli, Francesco and Gavioli, Riccardo 2023. Ageing curtails the diversity and functionality of nascent CD8 + T cell responses against SARS-CoV-2. Vaccines 11 (1) , 154. 10.3390/vaccines11010154

Proal, Amy D., VanElzakker, Michael B., Aleman, Soo, Bach, Katie, Boribong, Brittany P., Buggert, Marcus, Cherry, Sara, Chertow, Daniel S., Davies, Helen E., Dupont, Christopher L., Deeks, Steven G., Eimer, William, Ely, E. Wesley, Fasano, Alessio, Freire, Marcelo, Geng, Linda N., Griffin, Diane E., Henrich, Timothy J., Iwasaki, Akiko, Izquierdo-Garcia, David, Locci, Michela, Mehandru, Saurabh, Painter, Mark M., Peluso, Michael J., Pretorius, Etheresia, Price, David A.

, Putrino, David, Scheuermann, Richard H., Tan, Gene S., Tanzi, Rudolph E., VanBrocklin, Henry F., Yonker, Lael M. and Wherry, E. John 2023. SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC). Nature Immunology 24 , pp. 1616-1627. 10.1038/s41590-023-01601-2

Fahad, Ahmed S, Chung, Cheng-Yu, Lopez Acevedo, Sheila N, Boyle, Nicoleen, Madan, Bharat, Gutiérrez-González, Matias F, Matus-Nicodemos, Rodrigo, Laflin, Amy D, Ladi, Rukmini R, Zhou, John, Wolfe, Jacy, Llewellyn-Lacey, Sian, Koup, Richard A, Douek, Daniel C, Balfour Jr, Henry H, Price, David A

and DeKosky, Brandon J 2022. Immortalization and functional screening of natively paired human T cell receptor repertoires. Protein Engineering, Design & Selection 35 , gzab034. 10.1093/protein/gzab034

Kemming, Janine, Gundlach, Swantje, Panning, Marcus, Huzly, Daniela, Huang, Jiabin, Lütgehetmann, Marc, Pischke, Sven, Schulze zur Wiesch, Julian, Emmerich, Florian, Llewellyn-Lacey, Sian, Price, David A.

, Tanriver, Yakup, Warnatz, Klaus, Boettler, Tobias, Thimme, Robert, Hofmann, Maike, Fischer, Nicole and Neumann-Haefelin, Christoph 2022. Mechanisms of CD8+ T cell failure in chronic hepatitis E virus infection. Journal of Hepatology 77 (4) , pp. 978-990. 10.1016/j.jhep.2022.05.019

Goncharov, Mikhail, Bagaev, Dmitry, Shcherbinin, Dmitrii, Zvyagin, Ivan, Bolotin, Dmitry, Thomas, Paul G., Minervina, Anastasia A., Pogorelyy, Mikhail V., Ladell, Kristin

, Nguyen, Thi H. O., Rowntree, Louise C., Clemens, E. Bridie, Kedzierska, Katherine, Dolton, Garry, Rius Rafael, Cristina

, Sewell, Andrew

, Samir, Jerome, Luciani, Fabio, Zornikova, Ksenia V., Khmelevskaya, Alexandra A., Sheetikov, Saveliy A., Efimov, Grigory A., Chudakov, Dmitry and Shugay, Mikhail 2022. VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2. Nature Methods 19 (9) , 1017–1019. 10.1038/s41592-022-01578-0

Fielding, Ceri Alan

, Sabberwal, Pragati, Williamson, James C., Greenwood, Edward J.D., Crozier, Thomas WM, Zelek, Wioleta, Seow, Jeffrey, Graham, Carl, Huettner, Isabella, Edgeworth, Jonathan D., Price, David A.

, Merrick, Blair, Doores, Katie, Wilson, Sam J., Lehner, Paul J., Wang, Eddie C.Y.

and Stanton, Richard J.

2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 10.7554/eLife.74489

Pymm, Phillip, Tenzer, Stefan, Wee, Edmund, Weimershaus, Mirjana, Burgevin, Anne, Kollnberger, Simon, Gerstoft, Jan, Josephs, Tracy M., Ladell, Kristin

, Appay, Victor, Price, David A.

, Fugger, Lars, Bell, John I., Schild, Hansjörg, van Endert, Peter, Harkiolaki, Maria and Iversen, Astrid K.N. 2022. Epitope length variants balance protective immune responses and viral escape in HIV-1 infection. Cell Reports 38 (9) , 110449. 10.1016/j.celrep.2022.110449

Nicoli, Francesco, Cabral-Piccin, Mariela P., Papagno, Laura, Gallerani, Eleonora, Fusaro, Mathieu, Folcher, Victor, Dubois, Marion, Clave, Emmanuel, Vallet, Hélène, Frere, Justin J., Gostick, Emma, Llewellyn-Lacey, Sian, Price, David A.

, Toubert, Antoine, Dupré, Loïc, Boddaert, Jacques, Caputo, Antonella, Gavioli, Riccardo and Appay, Victor 2022. Altered basal lipid metabolism underlies the functional impairment of naive CD8+ T cells in elderly humans. The Journal of Immunology 208 (3) , 562–570. 10.4049/jimmunol.2100194

Gao, Yu, Cai, Curtis, Grifoni, Alba, Müller, Thomas R., Niessl, Julia, Olofsson, Anna, Humbert, Marion, Hansson, Lotta, Österborg, Anders, Bergman, Peter, Chen, Puran, Olsson, Annika, Sandberg, Johan K., Weiskopf, Daniela, Price, David A.

, Ljunggren, Hans-Gustaf, Karlsson, Annika C., Sette, Alessandro, Aleman, Soo and Buggert, Marcus 2022. Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant. Nature Medicine 28 (3) , pp. 472-476. 10.1038/s41591-022-01700-x

Campion, Suzanne L., Brenna, Elena, Thomson, Elaine, Fischer, Will, Ladell, Kristin

, Frahm, Nicole, McElrath, Juliana M., Cohen, Kristen W., Maenza, Janine R., Walsh, Stephen R., Baden, Lindsey R., Haynes, Barton F., Korber, Bette, Borrow, Persephone and McMichael, Andrew J. 2021. Preexisting memory CD4+ T cells contribute to the primary response in an HIV-1 vaccine trial. Journal of Clinical Investigation 131 (23) , e150823. 10.1172/JCI150823

Niessl, Julia, Sekine, Takuya, Lange, Joshua, Konya, Viktoria, Forkel, Marianne, Maric, Jovana, Rao, Anna, Mazzurana, Luca, Kokkinou, Efthymia, Weigel, Whitney, Llewellyn-Lacey, Sian, Hodcroft, Emma B., Karlsson, Annika C., Fehrm, Johan, Sundman, Joar, Price, David A.

, Mjösberg, Jenny, Friberg, Danielle and Buggert, Marcus 2021. Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue. Science Immunology 6 (64) , eabk0894. 10.1126/sciimmunol.abk0894

Man, Stephen

, Redman, James E.

, Cross, Deborah L., Cole, David K.

, Can, Ilona, Davies, Bethan, Hashimdeen, Shaikh Shimaz, Reid, Reiss, Llewellyn-Lacey, Sian, Miners, Kelly L., Ladell, Kristin

, Lissina, Anya, Brown, Paul E., Wooldridge, Linda, Price, David A.

and Rizkallah, Pierre J.

2021. Synthetic peptides with inadvertent chemical modifications can activate potentially autoreactive T cells. The Journal of Immunology 207 (4) , pp. 1009-1017. 10.4049/jimmunol.2000756

Clement, Mathew

, Knezevic, Lea, Dockree, Tamsin, McLaren, James E.

, Miners, Kelly L., Llewellyn-Lacey, Sian, Rubina, Anzelika, Francis, Ore, Cole, David K.

, Bridgeman, John S., Price, David A.

, van den Berg, Hugo A. and Wooldridge, Linda 2021. CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor. Proceedings of the National Academy of Sciences 118 (29) , e2019639118. 10.1073/pnas.2019639118

Heim, Kathrin, Binder, Benedikt, Sagar, Wieland, Dominik, Hensel, Nina, Llewellyn-Lacey, Sian, Gostick, Emma, Price, David A.

, Emmerich, Florian, Vingerhoet, Hildegard, Kraft, Anke R M, Cornberg, Markus, Boettler, Tobias, Neumann-Haefelin, Christoph, Zehn, Dietmar, Bengsch, Bertram, Hofmann, Maike and Thimme, Robert 2021. TOX defines the degree of CD8+ T cell dysfunction in distinct phases of chronic HBV infection. Gut 70 , pp. 1550-1560. 10.1136/gutjnl-2020-322404

Nicoli, Francesco, Pacifico, Salvatore, Gallerani, Eleonora, Marzola, Erika, Albanese, Valentina, Finessi, Valentina, Llewellyn-Lacey, Sian, Price, David A.

, Appay, Victor, Marconi, Peggy, Guerrini, Remo, Caputo, Antonella and Gavioli, Riccardo 2021. Use of a novel peptide welding technology platform for the development of B- and T-Cell epitope-based vaccines. Vaccines 9 (5) , 526. 10.3390/vaccines9050526

Hensel, Nina, Gu, Zuguang, Sagar, Wieland, Dominik, Jechow, Katharina, Kemming, Janine, Llewellyn-Lacey, Sian, Gostick, Emma, Sogukpinar, Oezlem, Emmerich, Florian, Price, David A.

, Bengsch, Bertram, Boettler, Tobias, Neumann-Haefelin, Christoph, Eils, Roland, Conrad, Christian, Bartenschlager, Ralf, Grün, Dominic, Ishaque, Naveed, Thimme, Robert and Hofmann, Maike 2021. Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection. Nature Immunology 22 (2) , 229–239. 10.1038/s41590-020-00817-w

Vlachava, Virginia-Maria

, Murrell, Isa, Zhuang, Lihui, Aicheler, Rebecca J., Lim, Eleanor, Miners, Kelly L., Ladell, Kristin

, Suárez, Nicolás M., Price, David A.

, Davison, Andrew J., Wilkinson, Gavin W.G., Wills, Mark R., Weekes, Michael P., Wang, Eddie C.Y.

and Stanton, Richard J.

2021. Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus. Journal of Clinical Investigation 131 (4) , e139296. 10.1172/JCI139296

Schulien, Isabel, Kemming, Janine, Oberhardt, Valerie, Wild, Katharina, Seidel, Lea M., Killmer, Saskia, Sagar, Daul, Franziska, Salvat Lago, Marilyn, Decker, Annegrit, Luxenburger, Hendrik, Binder, Benedikt, Bettinger, Dominik, Sogukpinar, Oezlem, Rieg, Siegbert, Panning, Marcus, Huzly, Daniela, Schwemmle, Martin, Kochs, Georg, Waller, Cornelius F., Nieters, Alexandra, Duerschmied, Daniel, Emmerich, Florian, Mei, Henrik E., Schulz, Axel Ronald, Llewellyn-Lacey, Sian, Price, David A.

, Boettler, Tobias, Bengsch, Bertram, Thimme, Robert, Hofmann, Maike and Neumann-Haefelin, Christoph 2021. Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells. Nature Medicine 27 (1) 10.1038/s41591-020-01143-2

Galletti, Giovanni, De Simone, Gabriele, Mazza, Emilia M.C., Puccio, Simone, Mezzanotte, Claudia, Bi, Timothy M., Davydov, Alexey N., Metsger, Maria, Scamardella, Eloise, Alvisi, Giorgia, Paoli, Federica De, Zanon, Veronica, Scarpa, Alice, Camisa, Barbara, Colombo, Federico S., Anselmo, Achile, Peano, Clelia, Polletti, Sara, Mavilio, Domenico, Gattinoni, Luca, Boi, Shannon K., Youngblood, Benjamin A., Jones, Rhiannon E., Baird, Duncan M.

, Gostick, Emma, Llewellyn-Lacey, Sian, Ladell, Kristin

, Chudakov, Dmitriy M., Newell, Evan W., Casucci, Monica and Lugli, Enrico 2020. Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans. Nature Immunology 21 , pp. 1552-1562. 10.1038/s41590-020-0791-5

Kasatskaya, Sofya A., Ladell, Kristin

, Egorov, Evgeniy S., Miners, Kelly L., Davydov, Alexey N., Metsger, Maria, Staroverov, Dmitry B., Matveyshina, Elena K., Shagina, Irina A., Mamedov, Ilgar Z., Izraelson, Mark, Shelyakin, Pavel V., Britanova, Olga V., Price, David A.

and Chudakov, Dmitriy M. 2020. Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs. eLife 9 , e57063. 10.7554/eLife.57063

Buggert, Marcus, Vella, Laura A., Nguyen, Son, Wu, Vincent H., Chen, Zeyu, Sekine, Takuya, Perez-Potti, André, Maldini, Colby R., Manne, Sasikanth, Darko, Samuel, Ransier, Amy, Kuri-Cervantes, Leticia, Japp, Alberto Sada, Brody, Irene Bukh, Ivarsson, Martin A., Gorin, Jean-Baptiste, Rivera-Ballesteros, Olga, Hertwig, Laura, Antel, Jack P., Johnson, Matthew E., Okoye, Afam, Picker, Louis, Vahedi, Golnaz, Sparrelid, Ernesto, Llewellyn-Lacey, Sian, Gostick, Emma, Sandberg, Johan K., Björkström, Niklas, Bar-Or, Amit, Dori, Yoav, Naji, Ali, Canaday, David H., Laufer, Terri M., Wells, Andrew D., Price, David A.

, Frank, Ian, Douek, Daniel C., Wherry, E. John, Itkin, Maxim G. and Betts, Michael R. 2020. The identity of human tissue-emigrant CD8+ T cells. Cell 183 (7) , pp. 1946-1961. 10.1016/j.cell.2020.11.019

Ahmed, Raya, Miners, Kelly L., Lahoz-Beneytez, Julio, Jones, Rhiannon E., Roger, Laureline, Baboonian, Christina, Zhang, Yan, Wang, Eddie C. Y.

, Hellerstein, Marc K., McCune, Joseph M., Baird, Duncan M.

, Macallan, Derek C., Asquith, Becca and Ladell, Kristin

2020. CD57+ Memory T Cells Proliferate In Vivo. Cell Reports 33 (11) , 108501. 10.1016/j.celrep.2020.108501

Ghosh, Sujal, Köstel Bal, Sevgi, Edwards, Emily S. J., Pillay, Bethany, Jiménez Heredia, Raúl, Erol Cipe, Funda, Rao, Geetha, Salzer, Elisabeth, Zoghi, Samaneh, Abolhassani, Hassan, Momen, Tooba, Gostick, Emma, Price, David A.

, Zhang, Yu, Oler, Andrew J., Gonzaga-Jauregui, Claudia, Erman, Baran, Metin, Ayse, Ilhan, Inci, Haskologlu, Sule, Islamoglu, Candan, Baskin, Kubra, Ceylaner, Serdar, Yilmaz, Ebru, Unal, Ekrem, Karakukcu, Musa, Berghuis, Dagmar, Cole, Theresa, Gupta, Aditya K., Hauck, Fabian, Kogler, Hubert, Hoepelman, Andy I. M., Baris, Safa, Karakoc-Aydiner, Elif, Ozen, Ahmet, Kager, Leo, Holzinger, Dirk, Paulussen, Michael, Krüger, Renate, Meisel, Roland, Oommen, Prasad T., Morris, Emma, Neven, Benedicte, Worth, Austen, van Montfrans, Joris, Fraaij, Pieter L. A., Choo, Sharon, Dogu, Figen, Davies, E. Graham, Burns, Siobhan, Dückers, Gregor, Becker, Ruy Perez, von Bernuth, Horst, Latour, Sylvain, Faraci, Maura, Gattorno, Marco, Su, Helen C., Pan-Hammarström, Qiang, Hammarström, Lennart, Lenardo, Michael J., Ma, Cindy S., Niehues, Tim, Aghamohammadi, Asghar, Rezaei, Nima, Ikinciogullari, Aydan, Tangye, Stuart G., Lankester, Arjan C. and Boztug, Kaan 2020. Extended clinical and immunological phenotype and transplant outcome in CD27 and CD70 deficiency. Blood 136 (23) , pp. 2638-2655. 10.1182/blood.2020006738

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, Restifo, Nicholas P and Roederer, Mario 2012. Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cell. Nature Protocols 8 (1) , pp. 33-42. 10.1038/nprot.2012.143

Doherty, T. Mark, Antrobus, Richard D., Lillie, Patrick J., Berthoud, Tamara K., Spencer, Alexandra J., McLaren, James E.

, Lambe, Teresa, Milicic, Anita, Price, David

, Hill, Adrian V. S. and Gilbert, Sarah C. 2012. A T Cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years. PLoS ONE 7 (10) , e48322. 10.1371/journal.pone.0048322

Maloveste, Sebastien M., Chen, Dan, Gostick, Emma, Vivian, Julian P., Plishka, Ronald J., Iyengar, Ranjini, Kruthers, Robin L., Buckler-White, Alicia, Brooks, Andrew G., Rossjohn, Jamie, Price, David

and Lafont, Bernard A. P. 2012. Degenerate recognition of MHC class I molecules with Bw4 and Bw6 motifs by a killer cell Ig-like receptor 3DL expressed by macaque NK cells. The Journal of Immunology 189 (9) , pp. 4338-4348. 10.4049/jimmunol.1201360

Wu, Y., Gao, F., Liu, J., Qi, J., Gostick, E., Price, David

and Gao, G. F. 2011. Structural basis of diverse peptide accommodation by the rhesus macaque MHC class I molecule Mamu-B*17: insights into immune protection from simian immunodeficiency virus. The Journal of Immunology 187 (12) , pp. 6382-6392. 10.4049/jimmunol.1101726

Vivian, Julian P., Duncan, Renee C., Berry, Richard, O'Connor, Geraldine M., Reid, Hugh H., Beddoe, Travis, Gras, Stephanie, Saunders, Philippa M., Olshina, Maya A., Widjaja, Jacqueline M. L., Harpur, Christopher M., Lin, Jie, Maloveste, Sebastien M., Price, David

, Lafont, Bernard A. P., McVicar, Daniel W., Clements, Craig S., Brooks, Andrew G. and Rossjohn, Jamie

2011. Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B [Letter]. Nature 479 (7373) , pp. 401-405. 10.1038/nature10517

Gattinoni, Luca, Lugli, Enrico, Ji, Yun, Pos, Zoltan, Paulos, Chrystal M., Quigley, Maire F., Almeida, Jorge R., Gostick, Emma, Yu, Zhiya, Carpenito, Carmine, Wang, Ena, Douek, Daniel C., Price, David

, June, Carl H., Marincola, Francesco M., Roederer, Mario and Restifo, Nicholas P. 2011. A human memory T cell subset with stem cell-like properties. Nature Medicine 17 (10) , pp. 1290-1297. 10.1038/nm.2446

Iglesias, M. C., Almeida, J. R., Fastenackels, S., van Bockel, D. J., Hashimoto, M., Venturi, V., Gostick, E., Urrutia, A., Wooldridge, L., Clement, Mathew

, Gras, S., Wilmann, P. G., Autran, B., Moris, A., Rossjohn, Jamie

, Davenport, M. P., Takiguchi, M., Brander, C., Douek, D. C., Kelleher, A. D., Price, David

and Appay, V. 2011. Escape from highly effective public CD8+ T-cell clonotypes by HIV. Blood 118 (8) , pp. 2138-2149. 10.1182/blood-2011-01-328781

Quigley, Máire F., Almeida, Jorge R., Price, David

and Douek, Daniel C. 2011. Unbiased molecular analysis of T cell receptor expression using template-switch achored RT-PCR. Current Protocols in Immunology , 94:VII:10.33:10.33.1–10.33.16.. 10.1002/0471142735.im1033s94

Clement, Mathew

, Ekeruche, Julia, Miles, John James, Edwards, Emily

, Dolton, Garry Michael, Williams, Tamsin, Schauenburg, Andrea J. A., Cole, David

, Lauder, Sarah Nicol, Gallimore, Awen Myfanwy

, Godkin, Andrew James

, Burrows, Scott R., Price, David

and Wooldridge, Linda 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2) , pp. 654-663. 10.4049/jimmunol.1003941

Haney, Danielle, Quigley, Máire F., Asher, Tedi E., Ambrozak, David R., Gostick, Emma, Price, David

, Douek, Daniel C. and Betts, Michael R. 2011. Isolation of viable antigen-specific CD8+ T cells based on membrane-bound tumor necrosis factor (TNF)-α expression. Journal of Immunological Methods 369 (1-2) , pp. 33-41. 10.1016/j.jim.2011.04.003

Kreutzman, A., Ladell, Kristin Ingrid

, Koechel, C., Gostick, Emma, Ekblom, M., Stenke, L., Melo, T., Einsele, H., Porkka, K., Price, David

, Mustjoki, S. and Seggewiss, R. 2011. Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation. Leukemia 25 (10) , pp. 1587-1597. 10.1038/leu.2011.135

Hindley, James Philip, Ferreira, Cristina, Jones, Emma, Lauder, Sarah Nicol, Ladell, Kristin

, Wynn, Katherine, Betts, Gareth James, Singh, Yogesh, Price, David

, Godkin, Andrew James

, Dyson, Julian and Gallimore, Awen Myfanwy

2011. Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Research 71 (3) , pp. 736-746. 10.1158/0008-5472.CAN-10-1797

Burwitz, Benjamin J., Ende, Zachary, Sudolcan, Benjamin, Reynolds, Matthew, Greene, Justin M., Bimber, Benjamin N., Almeida, Jorge R., Kurniawan, Monica, Venturi, Vanessa, Gostick, Emma, Wiseman, Roger W., Douek, Daniel C., Price, David

and O'Connor, David H. 2011. Simian immunodeficiency virus SIVmac239 nef vaccination elicits different tat28-35SL8-specific CD8+ T-cell clonotypes compared to a DNA prime/adenovirus type 5 boost regimen in rhesus macaques. Journal of Virology 85 (7) , pp. 3683-3689. 10.1128/JVI.02112-10

Nagai, Kozo, Ochi, Toshiki, Fujiwara, Hiroshi, An, Jun, Shirakata, Toshiaki, Mineno, Junichi, Kuzushima, Kiyotaka, Shiku, Hiroshi, Melenhorst, J. Joseph, Gostick, Emma, Price, David

, Ishii, Eiichi and Yasukawa, Masaki 2011. Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective antileukemia reactivity. Blood 119 (2) , pp. 368-376. 10.1182/blood-2011-06-360354

Minassian, A. M., Rowland, R., Beveridge, N. E. R., Poulton, I. D., Satti, I., Harris, S., Poyntz, H., Hamill, M., Griffiths, K., Sander, C. R., Ambrozak, D. R., Price, David

, Hill, B. J., Casazza, J. P., Douek, D. C., Koup, R. A., Roederer, M., Winston, A., Ross, J., Sherrard, J., Rooney, G., Williams, N., Lawrie, A. M., Fletcher, H. A., Pathan, A. A. and McShane, H. 2011. A phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults. BMJ Open 1 (2) , e000223. 10.1136/bmjopen-2011-000223

Schmidt, Julia, Neumann-Haefelin, Christoph, Altay, Tayibe, Gostick, Emma, Price, David

, Lohmann, Volker, Blum, Hubert E. and Thimme, Robert 2011. Immunodominance of HLA-A2-restricted hepatitis C virus-specific CD8+ T cell responses is linked to naive-precursor frequency. Journal of Virology 85 (10) , pp. 5232-5236. 10.1128/JVI.00093-11

Berger, Christoph T., Frahm, Nicole, Price, David

, Mothe, Beatriz, Ghebremichael, Musie, Hartman, Kari L., Henry, Leah M., Brenchley, Jason M., Ruff, Laura E., Venturi, Vanessa, Pereyra, Florencia, Sidney, John, Sette, Alessandro, Douek, Daniel C., Walker, Bruce D., Kaufmann, Daniel E. and Brander, Christian 2011. High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted gag-derived epitopes associated with relative HIV control. Journal of Virology 85 (18) , pp. 9334-9345. 10.1128/JVI.00460-11

O'Connor, Shelby L., Becker, Ericka A., Weinfurter, Jason T., Chin, Emily N., Budde, Melisa L., Gostick, Emma, Correll, Michael, Gleicher, Michael, Hughes, Austin L., Price, David

, Friedrich, Thomas C. and O'Connor, David H. 2011. Conditional CD8+ T cell escape during acute simian immunodeficiency virus infection. Journal of Virology 86 (1) , pp. 605-609. 10.1128/JVI.05511-11

Sloand, Elaine M., Melenhorst, J. Joseph, Tucker, Zachary C. G., Pfannes, Loretta, Brenchley, Jason M., Yong, Agnes, Visconte, Valeria, Wu, Colin, Gostick, Emma, Scheinberg, Phillip, Olnes, Matthew J., Douek, Daniel C., Price, David

, Barrett, A. John and Young, Neal S. 2011. T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy. Blood 117 (9) , pp. 2691-2699. 10.1182/blood-2010-04-277921

Yamamoto, Takuya, Price, David

, Casazza, Joseph P., Ferrari, Guido, Nason, Martha, Chattopadhyay, Pratip K., Roederer, Mario, Gostick, Emma, Katsikis, Peter D., Douek, Daniel C., Haubrich, Richard, Petrovas, Constantinos and Koup, Richard A. 2011. Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection. Blood 117 (18) , pp. 4805-4815. 10.1182/blood-2010-11-317297

Laugel, Bruno Frederic, Cole, David

, Clement, Mathew

, Wooldridge, Linda, Price, David

2011. The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells. Journal of Leukocyte Biology 90 (6) , pp. 1089-1099. 10.1189/jlb.0611316

Iglesias, Maria Candela, Almeida, Jorge R., Fastenackels, Solene, van Bockel, David J., Hashimoto, Masao, Venturi, Vanessa, Gostick, Emma, Urrutia, Alejandra, Wooldridge, Linda, Clement, Mathew

, Gras, Stephanie, Wilmann, Pascal G., Autran, Brigitte, Moris, Arnaud, Rossjohn, Jamie, Davenport, Miles P., Takiguchi, Masafumi, Brander, Christian, Douek, Daniel C., Kelleher, Anthony D., Price, David

and Appay, Victor 2011. Escape from highly effective public CD8+ T-cell clonotypes by HIV. Blood 118 (8) , pp. 2138-2149. 10.1182/blood-2011-01-328781

Vojnov, Lara, Martins, Mauricio A., Almeida, Jorge R., Ende, Zachary, Rakasz, Eva G., Reynolds, Matthew R., Leon, Enrique J., Weisgrau, Kim L., Burwitz, Benjamin J., Folkvord, Joy M., Veloso de Santana, Marlon G., Costa Neves, Patrícia C., Connick, Elizabeth, Skinner, Pamela J., Gostick, Emma, O'Connor, David H., Wilson, Nancy A., Bonaldo, Myrna C., Galler, Ricardo, Price, David

, Douek, Danny C. and Watkins, David I. 2011. GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo. PLoS ONE 6 (8) , e23515. 10.1371/journal.pone.0023515

Ruckwardt, Tracy J., Malloy, Allison M. W., Gostick, Emma, Price, David

, Dash, Pradyot, McClaen, Jennifer L., Thonas, Paul G. and Graham, Barney S. 2011. Neonatal cd8 t-cell hierarchy is distinct from adults and is influenced by intrinsic t cell properties in respiratory syncytial virus infected mice. PLoS Pathogens 7 (12) , e1002377. 10.1371/journal.ppat.1002377

Venturi, Vanessa, Quigley, Maire F., Greenaway, Hui Yee, Ng, Pauline C., Ende, Zachary S., McIntosh, Tina, Asher, Tedi E., Almeida, Jorge R., Levy, Samuel, Price, David

, Davenport, Miles P. and Douek, Daniel C. 2011. A mechanism for TCR sharing between T cell subsets and individuals revealed by pyrosequencing. The Journal of Immunology 186 (7) , pp. 4285-4294. 10.4049/jimmunol.1003898

Falkenburg, Willem J. J., Melenhorst, J. Joseph, van de Meent, Marian, Kester, Michel, Hombrink, Pleun, Heemskerk, Mirjam H. M., Hagedoorn, Renate S., Gostick, Emma, Price, David

, Falkenburg, J. H. Frederik, Barrett, A. John and Jedema, Inge 2011. Allogeneic HLA-A*02-restricted WT1-specific T cells from mismatched donors are highly reactive but show off-target promiscuity. The Journal of Immunology 187 (5) , pp. 2824-2833. 10.4049/jimmunol.1100852

Miles, John James, Douek, Daniel C. and Price, David

2011. Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination. Immunology and Cell Biology 89 (3) , pp. 375-387. 10.1038/icb.2010.139

van Bockel, David J., Price, David

, Munier, Mee Ling, Venturi, Vanessa, Asher, Tedi E., Ladell, Kristin Ingrid

, Greenaway, Hui Yee, Zaunders, John, Douek, Daniel C., Cooper, David A., Davenport, Miles P. and Kelleher, Anthony D. 2010. Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell response. The Journal of Immunology 186 (1) , pp. 359-371. 10.4049/jimmunol.1001807

Quigley, Maire F., Greenaway, Hui Yee, Venturi, Vanessa, Lindsay, Ross, Quinn, Kylie M., Seder, Robert A., Douek, Daniel C., Davenport, Miles P. and Price, David

2010. Convergent recombination shapes the clonotypic landscape of the naive T-cell repertoire. Proceedings of the National Academy of Sciences of the United States of America 107 (45) , pp. 19414-19419. 10.1073/pnas.1010586107

Humphreys, Ian R.

, Lee, Seung-Woo, Jones, Morgan, Loewendorf, Andrea, Gostick, Emma, Price, David A.

, Benedict, Chris A., Ware, Carl F. and Croft, Michael 2010. Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8+ T cells. European Journal of Immunology 40 (10) , pp. 2762-2768. 10.1002/eji.200940256

Jones, Morgan, Ladell, Kristin Ingrid

, Wynn, Katherine, Stacey, Maria A., Quigley, Maire F., Gostick, Emma, Price, David

and Humphreys, Ian R.

2010. IL-10 restricts memory T cell inflation during cytomegalovirus infection. The Journal of Immunology 185 (6) , pp. 3583-3592. 10.4049/jimmunol.1001535

Cole, David

, Edwards, Emily

, Wynn, Katherine, Clement, Mathew

, Miles, John James, Ladell, Kristin Ingrid

, Ekeruche, Julia, Gostick, Emma, Adams, Katherine J., Skowera, Ania, Peakman, Mark, Wooldridge, Linda, Price, David A.

2010. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. The Journal of Immunology 185 (4) , pp. 2600-2610. 10.4049/jimmunol.1000629

Rosario, Maximillian, Bridgeman, Anne, Quakkelaar, Esther D., Quigley, Maire F., Hill, Brenna J., Knudsen, Maria L., Ammendola, Virginia, Ljungberg, Karl, Borthwick, Nicola, Im, Eung-Jun, McMichael, Andrew J., Drijfhout, Jan W., Greenaway, Hui Yee, Venturi, Vanessa, Douek, Daniel C., Colloca, Stefano, Liljeström, Peter, Nicosia, Alfredo, Price, David A.

, Melief, Cornelis J. M. and Hanke, Tomás 2010. Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques. European Journal of Immunology 40 (7) , pp. 1973-1984. 10.1002/eji.201040344

Greene, Justin M., Lhost, Jennifer J., Burwitz, Benjamin J., Budde, Melisa L., Macnair, Caitlin E., Weiker, Madelyn K., Gostick, Emma, Friedrich, Thomas C., Broman, Karl W., Price, David

, O'Connor, Shelby L. and O'Connor, David H. 2010. Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239 nef-vaccinated macaques suppress SIVmac239 replication ex vivo. Journal of Virology 84 (7) , pp. 3362-3372. 10.1128/JVI.02028-09

Wooldridge, Linda, Laugel, Bruno Frederic, Ekeruche, Julia, Clement, Mathew

, van den Berg, Hugo A., Price, David

2010. CD8 controls T cell cross-reactivity. The Journal of Immunology 185 (8) , pp. 4625-4632. 10.4049/jimmunol.1001480

Chattopadhyay, Pratip K., Roederer, Mario and Price, David A.

2010. OMIP-002: Phenotypic analysis of specific human CD8+ T-cells using peptide-MHC class I multimers for any of four epitopes. Cytometry Part A 77A (9) , pp. 821-822. 10.1002/cyto.a.20945

Schaubert, Keri L., Price, David A.

, Salkowitz, Janelle R., Sewell, Andrew K.

, Sidney, John, Asher, Tedi, Blondelle, Sylvie E., Adams, Sharon, Marincola, Francesco M., Joseph, Aviva, Sette, Alessandro, Douek, Daniel C., Ayyavoo, Velpandi, Storkus, Walter, Leung, Ming-Ying, Ng, Hwee, Yang, Otto O., Goldstein, Harris, Wilson, Darcy B. and Kan-Mitchell, June 2010. Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes. European Journal of Immunology 40 (7) , pp. 1950-1962. 10.1002/eji.200940079

Wooldridge, Linda, Clement, Mathew

, Lissina, Anna, Edwards, Emily

, Ekeruche, Julia, Hewitt, R. E., Laugel, Bruno Frederic, Gostick, Emma, Cole, David

, Debets, R., Berrevoets, C., Miles, John James, Burrows, S. R., Price, David A.

2010. MHC Class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology 184 (7) , pp. 3357-3366. 10.4049/jimmunol.0902398

Van Tendeloo, V. F., Van de Velde, A., Van Driessche, A., Cools, N., Anguille, S., Ladell, Kristin Ingrid

, Gostick, Emma, Vermeulen, K., Pieters, K., Nijs, G., Stein, B., Smits, E. L., Schroyens, W. A., Gadisseur, A. P., Vrelust, I., Jorens, P. G., Goossens, H., de Vries, I. J., Price, David A.

, Oji, Y., Oka, Y., Sugiyama, H. and Berneman, Z. N. 2010. Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination. Proceedings of the National Academy of Sciences of the United States of America 107 (31) , pp. 13824-13829. 10.1073/pnas.1008051107

Giannopoulos, K., Dmoszynska, A., Kowal, M., Rolinski, J., Gostick, Emma, Price, David

, Greiner, J., Rojewski, M., Stilgenbauer, S., Döhner, H. and Schmitt, M. 2010. Peptide vaccination elicits leukemia-associated antigen-specific cytotoxic CD8+ T-cell responses in patients with chronic lymphocytic leukemia. Leukemia 24 (4) , pp. 798-805. 10.1038/leu.2010.29

Rosario, Maximillian, Hopkins, Richard, Fulkerson, John, Borthwick, Nicola, Quigley, Maire F., Joseph, Joan, Douek, Daniel C., Greenaway, Hui Yee, Venturi, Vanessa, Gostick, Emma, Price, David

, Both, Gerald W., Sadoff, Jerald C. and Hanke, Tomas 2010. Novel recombinant mycobacterium bovis BCG, ovine atadenovirus, and modified vaccinia virus ankara vaccines combine to induce robust human immunodeficiency virus-specific CD4 and CD8 T-cell responses in rhesus macaques. Journal of Virology 84 (12) , pp. 5898-5908. 10.1128/JVI.02607-09

Harris, L. D., Klatt, N. R., Vinton, C., Briant, J. A., Tabb, B., Ladell, Kristin Ingrid

, Lifson, Jeffrey, Estes, J. D., Price, David

, Hirsch, V. M. and Brenchley, J. M. 2010. Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques. Blood 116 (20) , pp. 4148-4157. 10.1182/blood-2010-05-283549

Melenhorst, J. Joseph, Leen, Ann M., Bollard, Catherine M., Quigley, Maire F., Price, David

, Rooney, Cliona M., Brenner, Malcolm K., Barrett, A. John and Heslop, Helen E. 2010. Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects. Blood 116 (22) , pp. 4700-4702. 10.1182/blood-2010-06-289991

Miles, John James, Bulek, Anna Marta, Cole, David

, Gostick, Emma, Schauenburg, Andrea J. A., Dolton, Garry Michael, Venturi, Vanessa, Davenport, Miles P., Tan, Mai Ping, Burrows, Scott R., Wooldridge, Linda, Price, David

, Rizkallah, Pierre

2010. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathogens 6 (11) , e1001198. 10.1371/journal.ppat.1001198

Subramanya, Sandesh, Armant, Myriam, Salkowitz, Janelle R., Nyakeriga, Alice M., Haridas, Viraga, Hasan, Maroof, Bansal, Anju, Goepfert, Paul A., Wynn, Katherine, Ladell, Kristin Ingrid

, N, Manjunath, Kan-Mitchell, June and Shankar, Premlata 2010. Enhanced induction of HIV-specific Cytotoxic T Lymphocytes by Dendritic cell-targeted delivery of SOCS-1 siRNA. Molecular Therapy 18 (11) , pp. 2028-2037. 10.1038/mt.2010.148

Burwitz, B. J., Bimber, B. N., O'Connor, S., Detmer, A., Gostick, Emma, Lank, S. M., Price, David A.

, Hughes, A. and O'Connor, D. 2009. P20-16. Ultra-deep pyrosequencing detects complex patterns of CD8+ T-lymphocyte escape in SIV-infected macaques. Retrovirology 6 (S3) , P386. 10.1186/1742-4690-6-S3-P386

Price, David A.

, Asher, Tedi E., Wilson, Nancy A., Nason, Martha C., Brenchley, Jason M., Metzler, Ian S., Venturi, Vanessa, Gostick, Emma, Chattopadhyay, Pratip K., Roederer, Mario, Davenport, Miles P., Watkins, David I. and Douek, Daniel C. 2009. Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection. Journal of Experimental Medicine 206 (4) , pp. 923-936. 10.1084/jem.20081127

Melenhorst, J. Joseph, Scheinberg, Phillip, Chattopadhyay, Pratip K., Gostick, Emma, Ladell, Kristin Ingrid

, Roederer, Mario, Hensel, Nancy F., Douek, Daniel C., Barrett, A. John and Price, David

2009. High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow. Blood 113 (10) , pp. 2238-2244. 10.1182/blood-2008-04-151969

Bimber, Benjamin N., Burwitz, Benjamin J., O'Connor, Shelby, Detmer, Ann, Gostick, Emma, Lank, Simon M., Price, David

, Hughes, Austin and O'Connor, David 2009. Ultradeep pyrosequencing detects complex patterns of CD8+ T-lymphocyte escape in simian immunodeficiency virus-infected macaques. Journal of Virology 83 (16) , pp. 8247-8253. 10.1128/JVI.00897-09

Lissina, Anna, Ladell, Kristin Ingrid

, Skowera, Ania, Clement, Mathew

, Edwards, Emily

, Seggewiss, Ruth, van den Berg, Hugo A., Gostick, Emma, Gallagher, Kathleen, Jones, Emma, Melenhorst, J. Joseph, Godkin, Andrew James

, Peakman, Mark, Price, David

and Wooldridge, Linda 2009. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. Journal of Immunological Methods 340 (1) , pp. 11-24. 10.1016/j.jim.2008.09.014

Almeida, J., Sauce, D., Price, David A.

, Papagno, L., Shin, S., Moris, A., Larsen, M., Pancino, G., Douek, D., Autran, B., Saez-Cirion, A. and Appay, V. 2009. P16-17. Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV suppressive activity. Retrovirology 6 (3) , P246. 10.1186/1742-4690-6-S3-P246

Cole, David

, Yuan, Fang, Rizkallah, Pierre

, Miles, John James, Gostick, Emma, Price, David

, Gao, George F., Jakobsen, Bent K. and Sewell, Andrew K.

2009. Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor. Journal of Biological Chemistry 284 (40) , 27281-27289. 10.1074/jbc.M109.022509

Wooldridge, Linda, Lissina, Anna, Cole, David

, van den Berg, Hugo A., Price, David

2009. Tricks with tetramers: how to get the most from multimeric peptide-MHC. Immunology 126 (2) , pp. 147-164. 10.1111/j.1365-2567.2008.02848.x

Geldmacher, Christof, Metzler, Ian S., Tovanabutra, Sodsai, Asher, Tedi E., Gostick, Emma, Ambrozak, David R., Petrovas, Constantinos, Schuetz, Alexandra, Ngwenyama, Njabulo, Kijak, Gustavo, Maboko, Leonard, Hoelscher, Michael, McCutchan, Francine, Price, David

, Douek, Daniel C. and Koup, Richard A. 2009. Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response. Blood 114 (8) , pp. 1553-1562. 10.1182/blood-2009-02-206193

Almeida, Jorge R., Sauce, Delphine, Price, David

, Papagno, Laura, Shin, So Youn, Moris, Arnaud, Larsen, Martin, Pancino, Gianfranco, Douek, Daniel C., Autran, Brigitte, Saez-Cirion, Asier and Appay, Victor 2009. Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity. Blood 113 (25) , pp. 6351-6360. 10.1182/blood-2009-02-206557

Scheinberg, Phillip, Melenhorst, Jan J., Brenchley, Jason M., Hill, Brenna J., Hensel, Nancy F., Chattopadhyay, Pratip K., Roederer, Mario, Picker, Louis J., Price, David

, Barrett, A. John and Douek, Daniel C. 2009. The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor. Blood 114 (24) , pp. 5071-5080. 10.1182/blood-2009-04-214684

Chattopadhyay, Pratip K., Betts, Michael R., Price, David

, Gostick, Emma, Horton, Helen, Roederer, Mario and De Rosa, Stephen C. 2009. The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression. Journal of Leukocyte Biology 85 (1) , pp. 88-97. 10.1189/jlb.0208107

Nakamoto, Nobuhiro, Cho, Hyosun, Shaked, Abraham, Olthoff, Kim, Valiga, Mary E., Kaminski, Mary, Gostick, Emma, Price, David

, Freeman, Gordon J., Wherry, E. John and Chang, Kyong-Mi 2009. Synergistic reversal of intrahepatic hcv-specific cd8 t cell exhaustion by combined pd-1/ctla-4 blockade. PLoS Pathogens 5 (2) , e1000313. 10.1371/journal.ppat.1000313

Petrovas, Constantinos, Chaon, Benjamin, Ambrozak, David R., Price, David

, Melenhorst, J. Joseph, Hill, Brenna J., Geldmacher, Christof, Casazza, Joseph P., Chattopadhyay, Pratip K., Roederer, Mario, Douek, Daniel C., Mueller, Yvonne M., Jacobson, Jeffrey M., Kulkarni, Viraj, Felber, Barbara K., Pavlakis, George N., Katsikis, Peter D. and Koup, Richard A. 2009. Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection. The Journal of Immunology 183 (2) , pp. 1120-1132. 10.4049/jimmunol.0900182

Honda, Mitsuo, Wang, Rui, Kong, Wing-Pui, Kanekiyo, Masaru, Akahata, Wataru, Xu, Ling, Matsuo, Kazuhiro, Natarajan, Kannan, Robinson, Howard, Asher, Tedi E., Price, David

, Douek, Daniel C., Margulies, David H. and Nabel, Gary J. 2009. Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity. The Journal of Immunology 183 (4) , pp. 2425-2434. 10.4049/jimmunol.0900581

Greenaway, Hui Yee, Kurniawan, Monica, Price, David

, Douek, Daniel C., Davenport, Miles P. and Venturi, Vanessa 2009. Extraction and characterization of the rhesus macaque T-cell receptor β-chain genes. Immunology and Cell Biology 87 (7) , pp. 546-553. 10.1038/icb.2009.38

Venturi, Vanessa, Chin, Hui Yee, Tedi, E. Asher, Ladell, Kristin Ingrid

, Scheinberg, Phillip, Bornstein, Ethan, van Bockel, David, Kelleher, Anthony D., Douek, Daniel C., Price, David A.

and Davenport, Miles P. 2008. TCR β-Chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV. Journal of Immunology 181 (11) , pp. 7853-7862. 10.4049/jimmunol.181.11.7853

Melenhorst, J. Joseph, Scheinberg, Phillip, Chattopadhyay, Pratip K., Lissina, Anna, Gostick, Emma, Cole, David

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, Barrett, A. John and Price, David

2008. Detection of low avidity CD8+ T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers. Journal of Immunological Methods 338 (1-2) , pp. 31-39. 10.1016/j.jim.2008.07.008

Ebinuma, Hirotoshi, Nakamoto, Nobuhiro, Li, Yun, Price, David

, Gostick, Emma, Levine, Bruce L., Tobias, J., Kwok, William W. and Chang, Kyong-Mi 2008. Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection. Journal of Virology 82 (10) , pp. 5043-5053. 10.1128/JVI.01548-07

Rehr, Manuela, Cahenzli, Julia, Haas, Anna, Price, David

, Gostick, Emma, Huber, Milo, Karrer, Urs and Oxenius, Annette 2008. Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy. Journal of Virology 82 (7) , pp. 3391-3404. 10.1128/JVI.02383-07

Weichsel, Ralf, Dix, Carolin, Wooldridge, Linda, Clement, Mathew

, Fenton-May, Angharad, Sewell, Andrew K.

, Zezula, Josef, Greiner, Elizabeth, Gostick, Emma, Price, David

, Einsele, Hermann and Seggewiss, Ruth 2008. Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clinical Cancer Research 14 (8) , pp. 2484-2491. 10.1158/1078-0432.CCR-07-4393

Price, David

, Bitmansour, Arlene D., Edgar, John B., Walker, Joshua M., Axthelm, Michael K., Douek, Daniel C. and Picker, Louis J. 2008. Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaques. Journal of Immunology 180 (1) , pp. 269-280. 10.4049/jimmunol.180.1.269

Melenhorst, J. Joseph, Lay, Matthew D. H., Price, David A.

, Adams, Sharon D., Zeilah, Joseph, Sosa, Edgardo, Hensel, Nancy F., Follmann, Dean, Douek, Daniel C., Davenport, Miles P. and Barrett, A. John 2008. Contribution of TCR-beta locus and HLA to the shape of the mature human Vbeta repertoire. Journal of Immunology 180 (10) , pp. 6484-6489.

Venturi, Vanessa, Chin, Hui Yee, Price, David A.

, Douek, Daniel C. and Davenport, Miles P. 2008. The role of production frequency in the sharing of simian immunodeficiency virus-specific CD8+ TCRs between macaques. Journal of Immunology 181 (4) , pp. 2597-2609. 10.4049/jimmunol.181.4.2597

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, Gostick, Emma, Scheinberg, Phillip, Barrett, A. John, Wooldridge, Linda, Roederer, Mario, Sewell, Andrew K.

and Price, David A.

2008. Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+T cells with peptide-major histocompatibility complex class I tetramers. Cytometry Part A 73A (11) , pp. 1001-1009. 10.1002/cyto.a.20642

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, Friedrich, T. C., Rakasz, E. G., Wilson, N. A., McDermott, A. B., Boyle, R., Allison, D. B., Burton, D. R., Koff, W. C. and Watkins, D. I. 2008. Macaques vaccinated with live-attenuated SIV control replication of heterologous virus. Journal of Experimental Medicine 205 (11) , pp. 2537-2550. 10.1084/jem.20081524

Nakamoto, Nobuhiro, Kaplan, David E., Coleclough, Jennifer, Li, Yun, Valiga, Mary E., Kaminski, Mary, Shaked, Abraham, Olthoff, Kim, Gostick, Emma, Price, David

, Freeman, Gordon J., Wherry, E. John and Chang, Kyong-Mi 2008. Functional restoration of HCV-specific CD8 T Cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134 (7) , pp. 1927-1937. 10.1053/j.gastro.2008.02.033

Smith, Miranda Z., Asher, Tedi E., Venturi, Vanessa, Davenport, Miles P., Douek, Daniel C., Price, David

and Kent, Stephen J. 2008. Limited maintenance of vaccine-induced simian immunodeficiency virus-specific CD8 T-cell receptor clonotypes after virus challenge. Journal of Virology 82 (15) , pp. 7357-7368. 10.1128/JVI.00607-08

Daucher, Marybeth, Price, David

, Brenchley, Jason M., Lamoreaux, Laurie, Metcalf, Julia A., Rehm, Catherine, Nies-Kraske, Elizabeth, Urban, Elizabeth, Yoder, Christian, Rock, Diane, Gumkowski, Julie, Betts, Michael R., Dybul, Mark R. and Douek, Daniel C. 2008. Virological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cells. Journal of Virology 82 (8) , pp. 4102-4114. 10.1128/JVI.02212-07

Mielke, Stephan, Nunes, Raquel, Rezvani, Katayoun, Fellowes, Vicki S., Venne, Annie, Solomon, Scott R., Fan, Yong, Gostick, Emma, Price, David

, Scotto, Christian, Read, Elizabeth J. and Barrett, A. John 2008. A clinical-scale selective allodepletion approach for the treatment of HLA-mismatched and matched donor-recipient pairs using expanded T lymphocytes as antigen-presenting cells and a TH9402-based photodepletion technique. Blood 111 (8) , pp. 4392-4402. 10.1182/blood-2007-08-104471

Brenchley, Jason M., Paiardini, Mirko, Knox, Kenneth S., Asher, Ava I., Cervasi, Barbara, Asher, Tedi E., Scheinberg, Phillip, Price, David

, Hage, Chadi A., Kholi, Lisa M., Khoruts, Alexander, Frank, Ian, Else, James, Schacker, Timothy, Silvestri, Guido and Douek, Daniel C. 2008. Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood 112 (7) , pp. 2826-2835. 10.1182/blood-2008-05-159301

Hestvik, A. L. K., Skorstad, G., Price, David

, Vartdal, F. and Holmoy, T. 2008. Multiple sclerosis: glatiramer acetate induces anti-inflammatory T cells in the cerebrospinal fluid. Multiple Sclerosis Journal 14 (6) , pp. 749-758. 10.1177/1352458508089411

Appay, Victor, Douek, Daniel C. and Price, David

2008. CD8+ T cell efficacy in vaccination and disease. Nature Medicine 14 (6) , pp. 623-628. 10.1038/nm.f.1774

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, Douek, Daniel C. and Davenport, Miles P. 2008. The molecular basis for public T-cell responses? Nature Reviews Immunology 8 (3) , pp. 231-238. 10.1038/nri2260

Brenchley, J. M., Knox, K. S., Asher, A. I., Price, David

, Kohli, L. M., Gostick, Emma, Hill, B. J., Hage, C. A., Brahmi, Z., Khoruts, A., Twigg, H. L., Schacker, T. W. and Douek, D. C. 2008. High frequencies of polyfunctional HIV-specific T cells are associated with preservation of mucosal CD4 T cells in bronchoalveolar lavage. Mucosal Immunology 1 (1) , pp. 49-58. 10.1038/mi.2007.5

Melenhorst, J. J., Lay, M. D. H., Price, David

, Adams, S. D., Zeilah, J., Sosa, E., Hensel, N. F., Follmann, D., Douek, D. C., Davenport, M. P. and Barrett, A. J. 2008. Contribution of TCR- locus and HLA to the shape of the mature human V repertoire. The Journal of Immunology 180 (10) , pp. 6484-6489. 10.4049/jimmunol.180.10.6484

Seggewiss, R., Price, David

and Purbhoo, Ma 2008. Immunomodulatory effects of imatinib and second-generation tyrosine kinase inhibitors on T cells and dendritic cells: an update. Cytotherapy 10 (6) , pp. 633-641. 10.1080/14653240802317639

Melenhorst, J.J, Scheinberg, P., Lu, J., Ambrozak, D.R, Sosa, E., Zhao, L., Hensel, N.F., Savani, B.N., Douek, D.C., Price, David

and Barrett, A.J. 2008. Regulatory T-cell depletion does not prevent emergence of new CD25+ FOXP3+ lymphocytes after antigen stimulation in culture. Cytotherapy 10 (2) , pp. 152-164. 10.1080/14653240701853536

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, Kallas, Esper G., Piontkivska, Helen, Hughes, Austin L., Sette, Alessandro and Watkins, David I. 2007. Cd8+ T cells from siv elite controller macaques recognize mamu-b*08-bound epitopes and select for widespread viral variation. PLoS ONE 2 (11) , e1152. 10.1371/journal.pone.0001152

Laugel, Bruno Frederic, Berg, Hugo A. van den, Gostick, Emma, Cole, David

, Wooldridge, Linda, Boulter, Jonathan M, Milicic, Anita, Price, David

2007. Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotxic T lymphocyte activation and tetramer properties. The Journal of Biological Chemistry 282 (33) , pp. 23799-22810. 10.1074/jbc.M700976200

Cole, David

, Pumphrey, Nicholas J., Boulter, Jonathan M., Sami, Malkit, Bell, John I., Gostick, Emma, Price, David

, Gao, George F., Sewell, Andrew K.

and Jakobsen, Bent K. 2007. Human TCR-binding affinity is governed by MHC class restriction. The Journal of Immunology 178 (9) , pp. 5727-5734. 10.4049/jimmunol.178.9.5727

Wooldridge, Linda, Lissina, Anna, Vernazza, Jonathan, Gostick, Emma, Laugel, Bruno Frederic, Hutchinson, Sarah L., Mirza, Fareed, Dunbar, P. Rod, Boulter, Jonathan M., Glick, Meir, Cerundolo, Vincenzo, Berg, Hugo A. van den, Price, David

2007. Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region. European Journal of Immunology 37 (5) , pp. 1323-1333. 10.1002/eji.200636765

Scheinberg, Phillip, Melenhorst, Jan J., Hill, Brenna J., Keyvanfar, Keyvan, Barrett, A. John, Price, David

and Douek, Daniel C. 2007. The clonal composition of human CD4+CD25+Foxp3+ cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements. Journal of Immunological Methods 321 (1-2) , pp. 107-120. 10.1016/j.jim.2007.01.005

Gostick, Emma, Cole, David

, Hutchinson, Sarah L., Wooldridge, Linda, Tafuro, Sabrina, Laugel, Bruno Frederic, Lissina, A., Oxenius, Annette, Boulter, Jonathan M., Price, David

2007. Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor. European Journal of Immunology 37 (2) , pp. 479-486. 10.1002/eji.200636243

Maness, Nicholas J., Valentine, Laura E., May, Gemma E., Reed, Jason, Piaskowski, Shari M., Soma, Taeko, Furlott, Jessica, Rakasz, Eva G., Friedrich, Thomas C., Price, David

, Gostick, Emma, Hughes, Austin L., Sidney, John, Sette, Alessandro, Wilson, Nancy A. and Watkins, David I. 2007. AIDS virus-specific CD8+T lymphocytes against an immunodominant cryptic epitope select for viral escape. Journal of Experimental Medicine 204 (11) , pp. 2505-2512. 10.1084/jem.20071261

Beveridge, Natalie, Price, David

, Casazza, Joseph, Pathan, Ansar, Sander, Clare, Asher, Tedi, Ambrozak, David, Precopio, MelissaL., Scheinberg, Phillip, Alder, Nicola C., Roederer, Mario, Koup, Richard A., Douek, Daniel C., Hill, Adrian V. S. and McShane, Helen 2007. Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctionalMycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations. European Journal of Immunology 37 (11) , pp. 3089-3100. 10.1002/eji.200737504

Almeida, Jorge R., Price, David

, Papagno, Laura, Arkoub, Zaïna Aït, Sauce, Delphine, Bornstein, Ethan, Asher, Tedi E., Samri, Assia, Schnuriger, Aurélie, Theodorou, Ioannis, Costagliola, Dominique, Rouzioux, Christine, Agut, Henri, Marcelin, Anne-Geneviève, Douek, Daniel, Autran, Brigitte and Appay, Victor 2007. Superior control of HIV-1 replication by CD8+T cells is reflected by their avidity, polyfunctionality, and clonal turnover. Journal of Experimental Medicine 204 (10) , pp. 2473-2485. 10.1084/jem.20070784

Yuan, Fang, Georgiou, Theonie, Hillon, Theresa, Gostick, Emma, Price, David

, Moysey, Ruth, Gavarret, Jessie, Vuidepot, Annelise, Sami, Malkit, Bell, John I., Gao, George F., Rizkallah, Pierre J. and Jakobsen, Bent K. 2007. Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 63 (9) , pp. 758-760. 10.1107/S1744309107037244

van Bockel, David, Price, David

, Asher, Tedi E., Venturi, Vanessa, Suzuki, Kazuo, Warton, Kristina, Davenport, Miles P., Cooper, David A., Douek, Daniel C. and Kelleher, Anthony D. 2007. Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood. Journal of Immunological Methods 326 (1-2) , pp. 127-138. 10.1016/j.jim.2007.07.016

Rezvani, K., Yong, A. S. M., Savani, B. N., Mielke, S., Keyvanfar, K., Gostick, E., Price, David

, Douek, D. C. and Barrett, A. J. 2007. Graft-versus-leukemia effects associated with detectable Wilms tumor-1-specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia. Blood 110 (6) , pp. 1924-1932. 10.1182/blood-2007-03-076844

Purbhoo, M. A., Li, Y., Sutton, D. H., Brewer, J. E., Gostick, E., Bossi, G., Laugel, B., Moysey, R., Baston, E., Liddy, N., Cameron, B., Bennett, A. D., Ashfield, R., Milicic, A., Price, David

, Classon, B. J., Sewell, A. K. and Jakobsen, B. K. 2007. The HLA A*0201-restricted hTERT540-548 peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor. Molecular Cancer Therapeutics 6 (7) , pp. 2081-2091. 10.1158/1535-7163.MCT-07-0092

Petrovas, C., Price, David

, Mattapallil, J., Ambrozak, D. R., Geldmacher, C., Cecchinato, V., Vaccari, M., Tryniszewska, E., Gostick, E., Roederer, M., Douek, D. C., Morgan, S. H., Davis, S. J., Franchini, G. and Koup, R. A. 2007. SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood 110 (3) , pp. 928-936. 10.1182/blood-2007-01-069112

Schaubert, K. L., Price, David

, Frahm, N., Li, J., Ng, H. L., Joseph, A., Paul, E., Majumder, B., Ayyavoo, V., Gostick, E., Adams, S., Marincola, F. M., Sewell, Andrew K.

, Altfeld, M., Brenchley, J. M., Douek, D. C., Yang, O. O., Brander, C., Goldstein, H. and Kan-Mitchell, J. 2007. Availability of a diversely Avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 gag p2419-27 epitope. The Journal of Immunology 178 (12) , pp. 7756-7766. 10.4049/jimmunol.178.12.7756

Precopio, Melissa L., Betts, Michael R., Parrino, Janie, Price, David

, Gostick, Emma, Ambrozak, David R., Asher, Tedi E., Douek, Daniel C., Harari, Alexandre, Pantaleo, Giuseppe, Bailer, Robert, Graham, Barney S., Roederer, Mario and Koup, Richard A. 2007. Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+T cell responses. Journal of Experimental Medicine 204 (6) , p. 1405. 10.1084/jem.20062363

Davenport, M., Price, David

and McMichael, A. 2007. The T cell repertoire in infection and vaccination: implications for control of persistent viruses. Current Opinion in Immunology 19 (3) , pp. 294-300. 10.1016/j.coi.2007.04.001

Laugel, Bruno, Price, David

, Milicic, Anita and Sewell, Andrew K.

2007. CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions. European Journal of Immunology 37 (4) , pp. 905-913. 10.1002/eji.200636718

Hryniewicz, A., Price, David

, Moniuszko, M., Boasso, A., Edghill-Spano, Y., West, S. M., Venzon, D., Vaccari, M., Tsai, W.-P., Tryniszewska, E., Nacsa, J., Villinger, F., Ansari, A. A., Trindade, C. J., Morre, M., Brooks, D., Arlen, P., Brown, H. J., Kitchen, C. M. R., Zack, J. A., Douek, D. C., Shearer, G. M., Lewis, M. G., Koup, R. A. and Franchini, G. 2007. Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virusmac251-infected macaques. The Journal of Immunology 178 (6) , pp. 3492-3504. 10.4049/jimmunol.178.6.3492

Price, David

, Silvestri, G., Brenchley, J.M. and Asher, T.W. 2006. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nature Medicine 12 (12) , pp. 1365-71. 10.1038/nm1511

Chattopadhyay, Pratip K., Price, David

, Harper, Theresa F., Betts, Michael R., Yu, Joanne, Gostick, Emma, Perfetto, Stephen P., Goepfert, Paul, Koup, Richard A., De Rosa, Stephen C., Bruchez, Marcel P. and Roederer, Mario 2006. Quantum dot semiconductor nanocrystals for immunophenotyping by polychomatic flow cytometry. Nature Medicine 12 (8) , pp. 972-7. 10.1038/nm1371

Wooldridge, Linda, Scriba, Thomas J., Milicic, Anita, Laugel, Bruno Frederic, Gostick, Emma, Price, David

, Phillips, Rodney E. and Sewell, Andrew

2006. Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers. European Journal of Immunology 36 (7) , pp. 1847-1855. 10.1002/eji.200635886

Casazza, Joseph P., Betts, Michael R., Price, David

, Precopio, Melissa L., Ruff, Laura E., Brenchley, Jason M., Hill, Brenna J., Roederer, Mario, Douek, Daniel C. and Koup, Richard A. 2006. Acquisition of direct antiviral effector functions by CMV-specific CD4+T lymphocytes with cellular maturation. Journal of Experimental Medicine 203 (13) , pp. 2865-2877. 10.1084/jem.20052246

Venturi, V., Kedzierska, K., Price, David

, Doherty, P. C., Douek, D. C., Turner, S. J. and Davenport, M. P. 2006. Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination. Proceedings of the National Academy of Sciences of the United States of America 103 (49) , pp. 18691-18696. 10.1073/pnas.0608907103

Leslie, A., Price, David

, Mkhize, P., Bishop, K., Rathod, A., Day, C., Crawford, H., Honeyborne, I., Asher, T. E., Luzzi, G., Edwards, A., Rosseau, C. M., Mullins, J. I., Tudor-Williams, G., Novelli, V., Brander, C., Douek, D. C., Kiepiela, P., Walker, B. D. and Goulder, P. J. R. 2006. Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype. The Journal of Immunology 177 (7) , pp. 4699-4708. 10.4049/jimmunol.177.7.4699

Petrovas, Constantinos, Casazza, Joseph P., Brenchley, Jason M., Price, David

, Gostick, Emma, Adams, William C., Precopio, Melissa L., Schacker, Timothy, Roederer, Mario, Douek, Daniel C. and Koup, Richard A. 2006. PD-1 is a regulator of virus-specific CD8+T cell survival in HIV infection. Journal of Experimental Medicine 203 (10) , pp. 2281-2292. 10.1084/jem.20061496

Brenchley, J. M., Ruff, L. E., Casazza, J. P., Koup, R. A., Price, David

and Douek, D. C. 2006. Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo. Journal of Virology 80 (14) , pp. 6801-6809. 10.1128/JVI.00070-06

Laugel, Bruno, Price, David

2006. On the path to TCR-directed therapeutics. Nature Biotechnology 24 (6) , pp. 615-616. 10.1038/nbt0606-615b

Scheinberg, Phillip, Price, David

, Ambrozak, David R., Barrett, A. John and Douek, Daniel C. 2006. Alloreactive T cell clonotype recruitment in a mixed lymphocyte reaction: Implications for graft engineering. Experimental Hematology 34 (6) , pp. 788-795. 10.1016/j.exphem.2006.03.001

Kan-Mitchell, J., Bajcz, M., Schaubert, K. L., Price, David

, Brenchley, J. M., Asher, T. E., Douek, D. C., Ng, H. L., Yang, O. O., Rinaldo, C. R., Benito, J. M., Bisikirska, B., Hegde, R., Marincola, F. M., Boggiano, C., Wilson, D., Abrams, J., Blondelle, S. E. and Wilson, D. B. 2006. Degeneracy and repertoire of the Human HIV-1 Gag p1777-85 CTL Response. The Journal of Immunology 176 (11) , pp. 6690-6701. 10.4049/jimmunol.176.11.6690

Brenchley, Jason M, Price, David

and Douek, Daniel C 2006. HIV disease: fallout from a mucosal catastrophe? Nature Immunology 7 (3) , pp. 235-239. 10.1038/ni1316

Price, David

, Brenchley, Jason M., Ruff, Laura E., Betts, Michael R., Hill, Brenna J., Roederer, Mario, Koup, Richard A., Migueles, Steven A., Gostick, Emma, Wooldridge, Linda, Sewell, Andrew

, Connors, Mark and Douek, Daniel C. 2005. Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. Journal of Experimental Medicine 202 (10) , pp. 1349-61. 10.1084/jem.20051357

Wooldridge, Linda, Berg, Hugo A. van den, Glick, Meir, Gostick, Emma, Laugel, Bruno Frederic, Hutchinson, Sarah L., Milicic, Anita, Brenchley, Jason M., Douek, Daniel C., Price, David

2005. Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface. The Journal of Biological Chemistry 280 (30) , pp. 27491-27501. 10.1074/jbc.M500555200

Laugel, B., Boulter, J. M., Lissin, N., Vuidepot, A., Gostick, E., Crotty, L. E., Douek, D. C., Hemelaar, J., Price, David

, Jakobsen, B. and Sewell, Andrew K.

2005. Design of soluble recombinant T Cell receptors for antigen targeting and T cell inhibition. Journal of Biological Chemistry 280 (3) , pp. 1882-1892. 10.1074/jbc.M409427200

Rezvani, K., Brenchley, J. M., Price, David

, Kilical, Y., Gostick, E., Sewell, Andrew K.

, Li, J., Mielke, S., Douek, D. C. and Barrett, A. J. 2005. T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization. Clinical Cancer Research 11 (24) , pp. 8799-8807. 10.1158/1078-0432.CCR-05-1314

Milicic, A., Price, David

, Zimbwa, P., Booth, B. L., Brown, H. L., Easterbrook, P. J., Olsen, K., Robinson, N., Gileadi, U., Sewell, A. K., Cerundolo, V. and Phillips, R. E. 2005. CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef. The Journal of Immunology 175 (7) , pp. 4618-4626. 10.4049/jimmunol.175.7.4618

Joos, B., Trkola, A., Fischer, M., Kuster, H., Rusert, P., Leemann, C., Boni, J., Oxenius, A., Price, David

, Phillips, R. E., Wong, J. K., Hirschel, B., Weber, R. and Gunthard, H. F. 2005. Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions. Journal of Virology 79 (14) , pp. 9026-9037. 10.1128/JVI.79.14.9026-9037.2005

Fujiwara, H., Melenhorst, J. J., El Ouriaghli, F., Kajigaya, S., Grube, M., Sconocchia, G., Rezvani, K., Price, David

, Hensel, N. F., Douek, D. C. and Barrett, A. J. 2005. In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins. Clinical Cancer Research 11 (12) , pp. 4495-4503. 10.1158/1078-0432.CCR-04-2363

Betts, M. R., Exley, B., Price, David

, Bansal, A., Camacho, Z. T., Teaberry, V., West, S. M., Ambrozak, D. R., Tomaras, G., Roederer, M., Kilby, J. M., Tartaglia, J., Belshe, R., Gao, F., Douek, D. C., Weinhold, K. J., Koup, R. A., Goepfert, P. and Ferrari, G. 2005. Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection. Proceedings of the National Academy of Sciences of the United States of America 102 (12) , pp. 4512-4517. 10.1073/pnas.0408773102

Seggewiss, R., Lore, K., Greiner, E., Magnusson, M. K., Price, David

, Douek, D. C., Dunbar, D. C. and Wiestner, A. 2005. Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood 105 (6) , pp. 2473-2479. 10.1182/blood-2004-07-2527

Casazza, J. P., Betts, M. R., Hill, B. J., Brenchley, J. M., Price, David

, Douek, D. C. and Koup, R. A. 2005. Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy. Journal of Virology 79 (6) , pp. 3653-3663. 10.1128/JVI.79.6.3653-3663.2005

Ellmerich, S., Mycko, M., Takacs, K., Waldner, H., Wahid, F. N., Boyton, R. J., King, R. H. M., Smith, P. A., Amor, S., Herlihy, A. H., Hewitt, R. E., Jutton, M., Price, David

, Hafler, D. A., Kuchroo, V. K. and Altmann, D. M. 2005. High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model. The Journal of Immunology 174 (4) , pp. 1938-1946. 10.4049/jimmunol.174.4.1938

Hewitt, R. E., Lissina, A., Green, A. E., Slay, E. S., Price, David

2005. The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. Clinical and Experimental Immunology 139 (1) , pp. 101-111. 10.1111/j.1365-2249.2005.02665.x

Price, David

, West, Sadie M., Betts, Michael R., Ruff, Laura E., Brenchley, Jason M., Ambrozak, David R., Edghill-Smith, Yvette, Kuroda, Marcelo J., Bogdan, Derek, Kunstman, Kevin, Letvin, Norman L., Franchini, Genoveffa, Wolinsky, Steven M., Koup, Richard A. and Douek, Daniel C. 2004. T cell receptor recognition motifs govern immune escape patterns in acute SIV infection. Immunity 21 (6) , pp. 793-803. 10.1016/j.immuni.2004.10.010

Green, A. E., Lissina, A., Hutchinson, S. L., Hewitt, R. E., Temple, B., James, D., Boulter, J. M., Price, David

2004. Recognition of nonpeptide antigens by human Vγ9Vδ2 T cells requires contact with cells of human origin. Clinical & Experimental Immunology 136 (3) , pp. 472-482. 10.1111/j.1365-2249.2004.02472.x

Brenchley, J. M., Hill, B. J., Ambrozak, D. R., Price, David

, Guenaga, F. J., Casazza, J. P., Kuruppu, J., Yazdani, J., Migueles, S. A., Connors, M., Roederer, M., Douek, D. C. and Koup, R. A. 2004. T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis. Journal of Virology 78 (3) , pp. 1160-1168. 10.1128/JVI.78.3.1160-1168.2004

Brenchley, Jason M., Schacker, Timothy W., Ruff, Laura E., Price, David

, Taylor, Jodie H., Beilman, Gregory J., Nguyen, Phuong L., Khoruts, Alexander, Larson, Matthew, Haase, Ashley T. and Douek, Daniel C. 2004. CD4+T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. Journal of Experimental Medicine 200 (6) , pp. 749-759. 10.1084/jem.20040874

Scherer, A., Frater, J., Oxenius, A., Agudelo, J., Price, David

, Gunthard, H. F., Barnardo, M., Perrin, L., Hirschel, B., Phillips, R. E. and McLean, A. R. 2004. Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS. Proceedings of the National Academy of Sciences of the United States of America 101 (33) , pp. 12266-12270. 10.1073/pnas.0404091101

Oxenius, Annette, Price, David

, Trkola, Alexandra, Edwards, Charles, Gostick, Emma, Zhang, Hua-Tang, Easterbrook, Philippa J., Tun, Tin, Johnson, Andrew, Waters, Anele, Holmes, Edward C. and Phillips, Rodney E. 2004. Loss of viral control in early HIV-1 infection Is temporally associated with sequential escape from CD8+ T cell responses and decrease in HIV-1-specific CD4+ and CD8+ T cell frequencies. International Journal of Infectious Diseases 190 (4) , pp. 713-721. 10.1086/422760

Crawford, M. P., Yan, S., Ortega, S. B., Mehta, R. S., Hewitt, R. E., Price, David

, Statsny, P., Douek, D. C., Koup, R. A., Racke, M. K. and Karandikar, N. J. 2004. High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay. Blood 103 (11) , pp. 4222-4231. 10.1182/blood-2003-11-4025

Betts, M. R., Price, David

, Brenchley, J. M., Lore, K., Guenaga, F. J., Smed-Sorensen, A., Ambrozak, D. R., Migueles, S. A., Connors, M., Roederer, M., Douek, D. C. and Koup, R. A. 2004. The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration. The Journal of Immunology 172 (10) , pp. 6407-6417. 10.4049/jimmunol.172.10.6407

Fujiwara, H., El Ouriaghli, F., Grube, M., Price, David

, Rezvani, K., Gostick, E., Sconocchia, G., Melenhorst, J., Hensel, N., Douek, D. C. and Barrett, A. J. 2004. Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase. Blood 103 (8) , pp. 3076-3083. 10.1182/blood-2003-07-2424

Oxenius, Annette, Price, David

, Hersberger, Martin, Schlaepfer, Erika, Weber, Rainer, Weber, Markus, Kundig, Thomas M., Böni, Jürg, Joller, Helen, Phillips, Rodney E., Flepp, Markus, Opravil, Milos and Speck, Roberto F. 2004. HIV-specific cellular immune response is inversely correlated with disease progression as defined by decline of CD4+T cells in relation to HIV RNA load. International Journal of Infectious Diseases 189 (7) , pp. 1199-1208. 10.1086/382028

Wooldridge, Linda, Hutchinson, Sarah L., Choi, Ed M., Lissina, Anna, Jones, Emma, Mirza, Fareed, Dunbar, P. Rod, Price, David

, Cerundolo, Vincenzo and Sewell, Andrew

2003. Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface. J Immunol 171 , pp. 6650-60.

Jones, Emma, Price, David

, Dahm-Vicker, Michaela, Cerundolo, Vincenzo, Klenerman, Paul and Gallimore, Awen

2003. The influence of macrophage inflammatory protein-1alpha on protective immunity mediated by antiviral cytotoxic T cells. Immunology 109 (1) , pp. 68-75. 10.1046/j.1365-2567.2003.01636.x

Price, David

, Scullard, G., Oxenius, A., Braganza, R., Beddows, S. A., Kazmi, S., Clarke, J. R., Johnson, G. E., Weber, J. N. and Phillips, R. E. 2003. Discordant outcomes following failure of antiretroviral therapy are associated with substantial differences in human immunodeficiency virus-specific cellular immunity. Journal of Virology 77 (10) , pp. 6041-6049. 10.1128/JVI.77.10.6041-6049.2003

Brookes, Roger H., Pathan, Ansar A., McShane, Helen, Hensmann, Meike, Price, David

and Hill, Adrian V. S. 2003. CD8+ T cell-mediated suppression of intracellularMycobacterium tuberculosis growth in activated human macrophages. European Journal of Immunology 33 (12) , pp. 3293-3302. 10.1002/eji.200324109

Betts, Michael R., Brenchley, Jason M., Price, David

, De Rosa, Stephen C., Douek, Daniel C., Roederer, Mario and Koup, Richard A. 2003. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. Journal of Immunological Methods 281 (1-2) , pp. 65-78. 10.1016/S0022-1759(03)00265-5

Rezvani, K., Grube, M., Benchley, J. M., Sconocchia, G., Fujiwara, H., Price, David

, Gostick, E., Yamada, K., Melenhorst, J., Childs, R., Hensel, N., Douek, D. C. and Barrett, A. J. 2003. Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation. Blood 102 (8) , pp. 2892-2900. 10.1182/blood-2003-01-0150

Hutchinson, S. L., Wooldridge, L., Tafuro, S., Laugel, B., Glick, M., Boulter, J. M., Jakobsen, B. K., Price, David

and Sewell, A. K. 2003. The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities. Journal of Biological Chemistry 278 (27) , pp. 24285-24293. 10.1074/jbc.M300633200

Fagard, C., Oxenius, A., Günthard, H., Garcia, F., Le Braz, M., Mestre, G., Battegay, M., Furrer, H., Vernazza, P., Bernasconi, E., Telenti, A., Weber, R., Leduc, D., Yerly, S., Price, David

, Dawson, S., Klimkait, T., Perneger, T. V., McLean, A., Clotet, B., Gatell, J. M., Perrin, L., Plana, M., Phillips, R. and Hirschel, B. 2003. A prospective trial of structured treatment interruptions in human immunodeficiency virus infection. Archives of Internal Medicine 163 (10) , pp. 1220-1226. 10.1001/archinte.163.10.1220

Oxenius, A., Price, David

, Gunthard, H. F., Dawson, S. J., Fagard, C., Perrin, L., Fischer, M., Weber, R., Plana, M., Garcia, F., Hirschel, B., McLean, A. and Phillips, R. E. 2002. Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection. Proceedings of the National Academy of Sciences of the United States of America 99 (21) , pp. 13747-13752. 10.1073/pnas.202372199

Oxenius, A., McLean, A. R., Fischer, M., Price, David

, Dawson, S. J., Hafner, R., Schneider, C., Joller, H., Hirschel, B., Phillips, R. E., Weber, R. and Gunthard, H. F. 2002. Human Immunodeficiency Virus-specific CD8+ T-Cell responses do not predict viral growth and clearance rates during structured intermittent antiretroviral therapy. Journal of Virology 76 (20) , pp. 10169-10176. 10.1128/JVI.76.20.10169-10176.2002

Glick, M., Price, David

, Vuidepot, A.-L., Andersen, T. B., Hutchinson, S. L., Laugel, B., Sewell, Andrew K.

, Boulter, J. M., Dunbar, P. R., Cerundolo, V., Oxenius, A., Bell, J. I., Richards, W. G. and Jakobsen, B. K. 2002. Novel CD8+ T cell antagonists based on 2-Microglobulin. Journal of Biological Chemistry 277 (23) , pp. 20840-20846. 10.1074/jbc.M201819200

Douek, Daniel C., Brenchley, Jason M., Betts, Michael R., Ambrozak, David R., Hill, Brenna J., Okamoto, Yukari, Casazza, Joseph P., Kuruppu, Janaki, Kunstman, Kevin, Wolinsky, Steven, Grossman, Zvi, Dybul, Mark, Oxenius, Annette, Price, David

, Connors, Mark and Koup, Richard A. 2002. HIV preferentially infects HIV-specific CD4+ T cells. Nature 417 (6884) , pp. 95-98. 10.1038/417095a

Kelleher, Anthony D., Sewell, Andrew K.

and Price, David

2002. Dyslipidemia due to retroviral protease inhibitors [Letter]. Nature Medicine 8 (4) , p. 308. 10.1038/nm0402-308a

Altes, Hester Korthals, Price, David

and Jansen, Vincent A.A. 2001. Effector cytotoxic T lymphocyte numbers induced by vaccination should exceed levels in chronic infection for protection from HIV. Vaccine 20 (1-2) , pp. 3-6. 10.1016/S0264-410X(01)00318-8

Oxenius, Annette, Price, David

, Dawson, Sara J., Tun, Tin, Easterbrook, Philippa J., Phillips, Rodney E. and Sewell, Andrew K.

2001. Cross-staining of cytotoxic T lymphocyte populations with peptide-MHC class I multimers of natural HIV-1 variant antigens. AIDS 15 (1) , pp. 121-122. 10.1097/00002030-200101050-00018

Purbhoo, M. A., Boulter, J. M., Price, David

, Vuidepot, A.-L., Hourigan, C. S., Dunbar, P. R., Olson, K., Dawson, S. J., Phillips, R. E., Jakobsen, B. K., Bell, J. I. and Sewell, Andrew K.

2001. The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor chain. Journal of Biological Chemistry 276 (35) , pp. 32786-32792. 10.1074/jbc.M102498200

Karadimitris, A., Gadola, S., Altamirano, M., Brown, D., Woolfson, A., Klenerman, P., Chen, J.-L., Koezuka, Y., Roberts, I. A. G., Price, David

, Dusheiko, G., Milstein, C., Fersht, A., Luzzatto, L. and Cerundolo, V. 2001. Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography. Proceedings of the National Academy of Sciences of the United States of America 98 (6) , pp. 3294-3298. 10.1073/pnas.051604498

Sewell, Andrew K.

and Price, David

2001. Dendritic cells and transmission of HIV-1. Trends in Immunology 22 (4) , pp. 173-175. 10.1016/S1471-4906(01)01866-X

Phillips, Rodney E, Oxenius, Annette, Price, David

and Bangham, Charles R.M 2000. AIDS: the evolving story. Trends in Microbiology 8 (4) , pp. 147-148. 10.1016/S0966-842X(00)01706-6

Oxenius, A., Price, David

, Easterbrook, P. J., O'Callaghan, C. A., Kelleher, A. D., Whelan, J. A., Sontag, G., Sewell, Andrew K.

and Phillips, R. E. 2000. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 97 (7) , pp. 3382-3387. 10.1073/pnas.97.7.3382

Price, David

, Klenerman, Paul, Booth, Bruce L, Phillips, Rodney E and Sewell, Andrew K

1999. Cytotoxic T lymphocytes, chemokines and antiviral immunity. Immunology Today 20 (5) , pp. 212-216. 10.1016/S0167-5699(99)01447-4

Sewell, Andrew K.

, Gerth, U. C., Price, David

, Purbhoo, M. A., Boulter, J. M., Gao, G. F., Bell, J. I., Phillips, R. E. and Jakobsen, B. K. 1999. Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. Nature Medicine 5 , pp. 399-404. 10.1038/7398

Lewis, J. W., Sewell, Andrew K.

and Elliot, T. 1998. HLA-A*0201 presents TAP-dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin. European Journal of Immunology 28 , pp. 3214-3220.

Price, David