Prod'homme, Virginie  ORCID: https://orcid.org/0000-0002-9664-4710, Sugrue, Daniel M., Stanton, Richard James ORCID: https://orcid.org/0000-0002-6799-1182, Nomoto, A., Davies, James Anthony ORCID: https://orcid.org/0000-0003-3569-4500, Rickards, Carole R., Cochrane, Daniel, Moore, Melanie, Wilkinson, Gavin William Grahame ORCID: https://orcid.org/0000-0002-5623-0126 and Tomasec, Peter
2010.
Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112.
Journal of General Virology
91
(8)
, pp. 2034-2039.
10.1099/vir.0.021931-0
|
Abstract
Human cytomegalovirus (HCMV) UL141 induces protection against natural killer cell-mediated cytolysis by downregulating cell surface expression of CD155 (nectin-like molecule 5; poliovirus receptor), a ligand for the activating receptor DNAM-1 (CD226). However, DNAM-1 is also recognized to bind a second ligand, CD112 (nectin-2). We now show that HCMV targets CD112 for proteasome-mediated degradation by 48 h post-infection, thus removing both activating ligands for DNAM-1 from the cell surface during productive infection. Significantly, cell surface expression of both CD112 and CD155 was restored when UL141 was deleted from the HCMV genome. While gpUL141 alone is sufficient to mediate retention of CD155 in the endoplasmic reticulum, UL141 requires assistance from additional HCMV-encoded functions to suppress expression of CD112.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Medicine Systems Immunity Research Institute (SIURI) |
| Subjects: | Q Science > QR Microbiology R Medicine > R Medicine (General) |
| Publisher: | Society for General Microbiology |
| ISSN: | 0022-1317 |
| Last Modified: | 20 Oct 2022 08:40 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/29199 |
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